Showing Protein Rho guanine nucleotide exchange factor 3 (CDBP05096)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP05096
Secondary Accession Numbers Not Available
Name Rho guanine nucleotide exchange factor 3
Description Not Available
Synonyms
  1. Exchange factor found in platelets and leukemic and neuronal tissues
  2. XPLN
Gene Name ARHGEF3
Protein Type Enzyme
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
guanyl-nucleotide exchange factor activity
Process
biological regulation
regulation of biological process
regulation of cellular process
intracellular signaling pathway
signaling
signaling pathway
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
regulation of ras protein signal transduction
regulation of rho protein signal transduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:3
Locus 3p21-p13
SNPs ARHGEF3
Gene Sequence 
>1581 bp
ATGGTGGCCAAGGATTACCCCTTCTACCTCACGGTCAAGAGAGCGAACTGCAGCCTGGAG
CTACCCCCGGCCAGCGGTCCGGCCAAGGACGCTGAGGAGCCTAGTAATAAACGGGTCAAA
CCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTA
AAGCGCTTCAGTCAAACCCTGCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGAC
ATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCCCCCTCGAGCACGAAACGGAGAGAT
AGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAA
ATCAAACGTCAGGAGGCGATCTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGAC
TTGAAATTAGCAAAAAAGGCCTATCATGACCCCATGCTGAAACTCTCCATAATGACAGAA
CAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTC
CTTAGTCAGCTTCGAGATGTTAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATC
CTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGATAGCTACTGCAGCAATCAAGTAGCC
GCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGA
TGTTTAGAATCCCCCTTTAGCCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGA
AGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAAATCTTGAGGCACACACCAAATGAT
AATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAA
ATCAACACCAAGACTGGTGAATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTG
GAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCTCGAGTCTTGTGTTGTCATGGTGAA
CTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATC
ACTCGAGCCGTCACCCACAATGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCC
GTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGAGAAGTGAGGCTGGGTGGCTCCCTG
CGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAAT
GGATCCCAAAGTCAGACCCACTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGG
CTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTGTGTGCTGCCGGGCAAGCTGGGGTG
CTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAA
ACAAAACTTGAGCAGATGGACCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGT
GAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACAGACTCTTCCTGTGGAAACAGCAGG
CACGGTGAAAGTAACGTCTGA
Protein Properties
Number of Residues 526
Molecular Weight 59782.1
Theoretical pI 6.38
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Rho guanine nucleotide exchange factor 3
MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPL
KRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKE
IKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEEL
LSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQR
CLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAE
INTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVI
TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKN
GSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGE
TKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV
GenBank ID Protein 9506401
UniProtKB/Swiss-Prot ID Q9NR81
UniProtKB/Swiss-Prot Entry Name ARHG3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_019555.2
GeneCard ID ARHGEF3
GenAtlas ID ARHGEF3
HGNC ID HGNC:683
References
General References Not Available