Showing Protein Guanine nucleotide exchange factor GEFT (CDBP05085)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP05085
Secondary Accession Numbers Not Available
Name Guanine nucleotide exchange factor GEFT
Description Not Available
Synonyms
  1. Rac/Cdc42/Rho exchange factor GEFT
  2. RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
  3. p63RhoGEF
Gene Name GEFT
Protein Type Enzyme
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of small gtpase mediated signal transduction
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. myofibril
  4. sarcomere
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q13.3
SNPs GEFT
Gene Sequence 
>1743 bp
ATGCGGGGGGGGCACAAAGGGGGTCGCTGTGCCTGTCCCCGTGTGATCCGAAAAGTGCTG
GCAAAATGCGGCTGCTGCTTCGCCCGGGGGGGACGTGAATCCTATTCCATTGCGGGCAGT
GAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGGCCCCAGCTCT
GGCCTCAGCTCTGGCCCCTGTTCCCCAGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGA
TGGTTGGATCATTCCAAACATTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCAGGCA
GGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGAGCTGCCGGAA
CTGACCTTGCTGACCACACTGTTGGAGGGCCCTGGAGATAAGACGCAGCCACCTGAAGAG
GAGACTTTGTCCCAAGCCCCTGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGAAAGG
AGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGACGACTTGGGG
CAGATTGTGGAGGGTTATATGGCCACCATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGA
GGCCGTGACAGGATTGTGTTTGGGAATATCCAGCAAATCTATGAGTGGCACCGAGACTAT
TTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCAGCTATTCATC
AAACACGAGCGCCGGCTGCATATGTATGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAG
CATGTGGTGTCAGAGTTTGGGGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGGGCAC
CGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAAATACCAGCTG
CTGCTCAAGGATTTTCTCAAGTATTACAATAGAGCTGGGATGGATACTGCAGACCTAGAG
CAAGCTGTGGAGGTCATGTGCTTTGTGCCCAAGCGCTGCAACGATATGATGACGCTGGGG
AGATTGCGGGGATTTGAGGGCAAACTGACTGCTCAGGGGAAGCTCTTGGGCCAGGACACT
TTCTGGGTCACCGAGCCTGAGGCTGGAGGGCTGCTGTCTTCCCGAGGTCGAGAGAGGCGC
GTCTTCCTCTTTGAGCAAATCATCATCTTCAGTGAAGCCCTGGGAGGAGGAGTGAGAGGT
GGAACACAGCCTGGATATGTATACAAGAACAGCATTAAGGTGAGCTGCCTGGGACTGGAG
GGGAACCTCCAAGGTGACCCTTGCCGCTTTGCACTGACCTCCAGAGGGCCAGAGGGTGGG
ATCCAGCGCTATGTCCTGCAGGCTGCAGACCCTGCTATCAGTCAGGCCTGGATCAAGCAT
GTGGCTCAGATCTTGGAGAGCCAACGGGACTTCCTCAACGCATTGCAGTCACCCATTGAG
TACCAGAGACGGGAGAGCCAGACCAACAGCCTGGGGCGGCCAAGAGGGCCTGGAGTGGGG
AGCCCTGGAAGAATTCGGCTTGGAGATCAGGCCCAGGGCAGCACACACACACCCATCAAT
GGCTCTCTCCCCTCTCTGCTGCTGTCACCCAAAGGGGAGGTGGCCAGAGCCCTCTTGCCA
CTGGATAAACAGGCCCTTGGTGACATCCCCCAGGCTCCCCATGACTCTCCTCCAGTCTCT
CCAACTCCAAAAACCCCTCCCTGCCAAGCCAGACTTGCCAAGCTGGATGAAGATGAGCTG
TAA
Protein Properties
Number of Residues 580
Molecular Weight 63842.1
Theoretical pI 6.58
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Guanine nucleotide exchange factor GEFT
MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS
GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE
LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG
QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI
KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL
LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT
FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE
GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE
YQRRESQTNSLGRPRGPGVGSPGRIQLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP
LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL
GenBank ID Protein 150417975
UniProtKB/Swiss-Prot ID Q86VW2
UniProtKB/Swiss-Prot Entry Name GEFT_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_182947.2
GeneCard ID GEFT
GenAtlas ID ARHGEF25
HGNC ID HGNC:30275
References
General References Not Available