Showing Protein Guanine nucleotide exchange factor GEFT (CDBP05085)
| Identification | ||||||||||||||||||||
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| HMDB Protein ID | CDBP05085 | |||||||||||||||||||
| Secondary Accession Numbers | Not Available | |||||||||||||||||||
| Name | Guanine nucleotide exchange factor GEFT | |||||||||||||||||||
| Description | Not Available | |||||||||||||||||||
| Synonyms |
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| Gene Name | GEFT | |||||||||||||||||||
| Protein Type | Enzyme | |||||||||||||||||||
| Biological Properties | ||||||||||||||||||||
| General Function | Involved in Rho guanyl-nucleotide exchange factor activity | |||||||||||||||||||
| Specific Function | May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis | |||||||||||||||||||
| GO Classification |
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| Cellular Location |
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| Pathways | Not Available | |||||||||||||||||||
| Gene Properties | ||||||||||||||||||||
| Chromosome Location | Chromosome:1 | |||||||||||||||||||
| Locus | 12q13.3 | |||||||||||||||||||
| SNPs | GEFT | |||||||||||||||||||
| Gene Sequence |
>1743 bp ATGCGGGGGGGGCACAAAGGGGGTCGCTGTGCCTGTCCCCGTGTGATCCGAAAAGTGCTG GCAAAATGCGGCTGCTGCTTCGCCCGGGGGGGACGTGAATCCTATTCCATTGCGGGCAGT GAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGGCCCCAGCTCT GGCCTCAGCTCTGGCCCCTGTTCCCCAGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGA TGGTTGGATCATTCCAAACATTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCAGGCA GGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGAGCTGCCGGAA CTGACCTTGCTGACCACACTGTTGGAGGGCCCTGGAGATAAGACGCAGCCACCTGAAGAG GAGACTTTGTCCCAAGCCCCTGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGAAAGG AGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGACGACTTGGGG CAGATTGTGGAGGGTTATATGGCCACCATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGA GGCCGTGACAGGATTGTGTTTGGGAATATCCAGCAAATCTATGAGTGGCACCGAGACTAT TTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCAGCTATTCATC AAACACGAGCGCCGGCTGCATATGTATGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAG CATGTGGTGTCAGAGTTTGGGGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGGGCAC CGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAAATACCAGCTG CTGCTCAAGGATTTTCTCAAGTATTACAATAGAGCTGGGATGGATACTGCAGACCTAGAG CAAGCTGTGGAGGTCATGTGCTTTGTGCCCAAGCGCTGCAACGATATGATGACGCTGGGG AGATTGCGGGGATTTGAGGGCAAACTGACTGCTCAGGGGAAGCTCTTGGGCCAGGACACT TTCTGGGTCACCGAGCCTGAGGCTGGAGGGCTGCTGTCTTCCCGAGGTCGAGAGAGGCGC GTCTTCCTCTTTGAGCAAATCATCATCTTCAGTGAAGCCCTGGGAGGAGGAGTGAGAGGT GGAACACAGCCTGGATATGTATACAAGAACAGCATTAAGGTGAGCTGCCTGGGACTGGAG GGGAACCTCCAAGGTGACCCTTGCCGCTTTGCACTGACCTCCAGAGGGCCAGAGGGTGGG ATCCAGCGCTATGTCCTGCAGGCTGCAGACCCTGCTATCAGTCAGGCCTGGATCAAGCAT GTGGCTCAGATCTTGGAGAGCCAACGGGACTTCCTCAACGCATTGCAGTCACCCATTGAG TACCAGAGACGGGAGAGCCAGACCAACAGCCTGGGGCGGCCAAGAGGGCCTGGAGTGGGG AGCCCTGGAAGAATTCGGCTTGGAGATCAGGCCCAGGGCAGCACACACACACCCATCAAT GGCTCTCTCCCCTCTCTGCTGCTGTCACCCAAAGGGGAGGTGGCCAGAGCCCTCTTGCCA CTGGATAAACAGGCCCTTGGTGACATCCCCCAGGCTCCCCATGACTCTCCTCCAGTCTCT CCAACTCCAAAAACCCCTCCCTGCCAAGCCAGACTTGCCAAGCTGGATGAAGATGAGCTG TAA |
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| Protein Properties | ||||||||||||||||||||
| Number of Residues | 580 | |||||||||||||||||||
| Molecular Weight | 63842.1 | |||||||||||||||||||
| Theoretical pI | 6.58 | |||||||||||||||||||
| Pfam Domain Function |
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| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Guanine nucleotide exchange factor GEFT MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE YQRRESQTNSLGRPRGPGVGSPGRIQLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL |
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| External Links | ||||||||||||||||||||
| GenBank ID Protein | 150417975 | |||||||||||||||||||
| UniProtKB/Swiss-Prot ID | Q86VW2 | |||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | GEFT_HUMAN | |||||||||||||||||||
| PDB IDs | Not Available | |||||||||||||||||||
| GenBank Gene ID | NM_182947.2 | |||||||||||||||||||
| GeneCard ID | GEFT | |||||||||||||||||||
| GenAtlas ID | ARHGEF25 | |||||||||||||||||||
| HGNC ID | HGNC:30275 | |||||||||||||||||||
| References | ||||||||||||||||||||
| General References | Not Available | |||||||||||||||||||