| Identification |
|---|
| HMDB Protein ID
| CDBP05084 |
| Secondary Accession Numbers
| Not Available |
| Name
| Engulfment and cell motility protein 3 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| ELMO3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 |
| GO Classification
|
| Component |
| cytoskeleton |
| organelle |
| non-membrane-bounded organelle |
| intracellular non-membrane-bounded organelle |
| Process |
| cellular process |
| cellular membrane organization |
| membrane invagination |
| endocytosis |
| phagocytosis |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q22.1 |
| SNPs
| ELMO3 |
| Gene Sequence
|
>2322 bp
ATGGCCAGGAGCAGCAGTCTGGGCCGCGAGTGCGGGACACCGAGGTCAGGTCTCGGAAAG
GGAGGACCTCCTCGTCCCCAGGGGCCCCAGGCCAGGTGCACCCTTGGCCGCAGGTGCACG
GTCTCCGGAAAGTGCAGGCGCCCACGTCCCAGCTGGACCATGGCGCCTCCGCGGAACGTG
GTGAAGATTGCCATCAAGATGCGTGACGCCATCCCGCAGCTCATCCAGCTGGACCAGGCG
AAGCCCCTGGCCGCTGTGCTGAAGGAGGTGTGCGACGCGTGGAGCCTGACGCACTCTGAG
CGTTACGCCCTGCAGTTTGCGGATGGGCACCGGAGATACATCACCGAGAATAACCGCGCG
GAGATCAAGAATGGCAGCATCCTGTGCCTCAGCACGGCCCCAGACCTTGAGGCTGAGCAG
CTCTTGGGTGGGCTGCAGAGTAACAGTCCTGAAGGGCGCCGGGAAGCCCTGAGGCGCCTT
GTTCCGCTGGCCTCGGACATGATCTTTGCCAGGGAGGTCATCAGCCGTAATGGGCTCCAG
ATACTAGGCACCATCATTGAAGATGGGGACGACCTAGGAGAGGTGCTGGCCCTCAGCCTG
AGGGCCTTCTCAGAGCTCATGGAGCACGGCGTGGTGTCCTGGGAGACTCTGAGCATCCCC
TTTGTGAGGAAGGTGGTGTGCTACGTGAACATGAACCTCATGGATGCCTCCGTGCCTCCC
CTGGCCCTTGGGCTGCTGGAGAGTGTGACCTTGAGCAGCCCAGCCCTGGGCCAGCTGGTC
AAGAGCGAGGTGCCCCTGGATAGGCTGCTGGTGCACCTACAGGTGATGAACCAGCAGCTG
CAAACCAAGGCCATGGCCCTGCTGACAGCCTTGCTGCAGGGGGCCAGCCCTGTGGAACGC
AAGCACATGCTTGACTATCTTTGGCAGAGGAACCTTCGCCAGTTCATCTATAAGAACATC
ATCCACAGTGCAGCACCAATGGGCGACGAGATGGCTCATCACCTGTACGTACTGCAGGCT
CTCATGCTGGGGCTGCTGGAGCCGCGCATGCGGACGCCCCTGGACCCCTACAGCCAGGAG
CAGCGGGAGCAGCTGCAGGTCCTACGCCAGGCTGCCTTCGAGGTGGAGGGGGAGTCCTCG
GGTGCCGGGCTAAGTGCTGACCGTCGCCGTTCCCTCTGTGCCCGAGAGTTCCGCAAACTG
GGCTTTTCTAACAGCAACCCAGCACAGGACCTGGAGCGCGTGCCCCCCGGTCTGCTGGCC
CTGGACAACATGTTGTACTTCTCCAGAAACGCGCCCAGCGCGTACAGCCGGTTTGTGTTG
GAGAACAGCAGCCGCGAGGACAAGCACGAGTGCCCCTTTGCCCGGGGCAGCATCCAGCTG
ACGGTGCTGCTGTGTGAGCTGCTCCGTGTTGGGGAGCCCTGCTCTGAGACAGCCCAGGAC
TTCTCACCCATGTTCTTCGGCCAAGACCAGAGCTTCCACGAGCTCTTCTGTGTGGGCATC
CAGCTGTTGAATAAGACCTGGAAGGAGATGCGGGCTACACAGGAGGACTTCGACAAGGTC
ATGCAGGTGGTGCGGGAGCAGCTGGCCCGCACTCTGGCCCTGAAGCCCACTTCCCTGGAG
CTCTTCCGAACCAAGGTGAATGCGCTCACTTATGGGGAGGTGCTGCGGCTGCGGCAGACT
GAACGGCTGCACCAGGAGGGCACACTGGCTCCCCCTATACTGGAGCTGCGGGAGAAGCTG
AAGCCAGAGCTCATGGGCCTGATCCGCCAGCAGCGCTTGCTCCGCCTCTGTGAGGGGACG
CTCTTCCGCAAGATCAGCAGCCGGCGGCGCCAGGATAAGCTGTGGTTCTGCTGCCTGTCC
CCCAACCACAAGCTGCTGCAGTACGGAGACATGGAGGAGGGCGCCAGCCCGCCTACCCTG
GAGAGTCTGCCCGAGCAACTCCCTGTGGCCGACATGAGGGCACTCCTGACAGGCAAGGAC
TGCCCCCATGTCCGGGAGAAGGGCTCCGGGAAGCAGAACAAGGACCTCTATGAGTTGGCC
TTCTCAATCAGCTATGACCGTGGGGAGGAGGAAGCGTACCTCAACTTCATTGCCCCCTCC
AAGCGGGAGTTCTACCTGTGGACAGATGGGCTCAGTGCCTTGCTGGGCAGTCCCATGGGC
AGCGAGCAGACACGGCTGGACCTGGAGCAGCTGCTGACCATGGAGACCAAGCTGCGTCTG
CTGGAGCTGGAGAACGTGCCCATCCCCGAGCGGCCACCCCCTGTGCCCCCACCCCCCACC
AACTTCAACTTCTGCTATGACTGCAGCATCGCTGAACCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 720 |
| Molecular Weight
| 81466.2 |
| Theoretical pI
| 6.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Engulfment and cell motility protein 3
MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRY
ITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREV
ISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNL
MDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQ
GASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTP
LDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLER
VPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEP
CSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLA
LKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRL
LRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMR
ALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSA
LLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP
|
| External Links |
|---|
| GenBank ID Protein
| 87298935 |
| UniProtKB/Swiss-Prot ID
| Q96BJ8 |
| UniProtKB/Swiss-Prot Entry Name
| ELMO3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| ELMO3 |
| GenAtlas ID
| ELMO3 |
| HGNC ID
| HGNC:17289 |
| References |
|---|
| General References
| Not Available |