Showing Protein Engulfment and cell motility protein 3 (CDBP05084)
| Identification | ||||||||||||
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| HMDB Protein ID | CDBP05084 | |||||||||||
| Secondary Accession Numbers | Not Available | |||||||||||
| Name | Engulfment and cell motility protein 3 | |||||||||||
| Description | Not Available | |||||||||||
| Synonyms | Not Available | |||||||||||
| Gene Name | ELMO3 | |||||||||||
| Protein Type | Enzyme | |||||||||||
| Biological Properties | ||||||||||||
| General Function | Involved in binding | |||||||||||
| Specific Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 | |||||||||||
| GO Classification |
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| Cellular Location |
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| Pathways | Not Available | |||||||||||
| Gene Properties | ||||||||||||
| Chromosome Location | Chromosome:1 | |||||||||||
| Locus | 16q22.1 | |||||||||||
| SNPs | ELMO3 | |||||||||||
| Gene Sequence |
>2322 bp ATGGCCAGGAGCAGCAGTCTGGGCCGCGAGTGCGGGACACCGAGGTCAGGTCTCGGAAAG GGAGGACCTCCTCGTCCCCAGGGGCCCCAGGCCAGGTGCACCCTTGGCCGCAGGTGCACG GTCTCCGGAAAGTGCAGGCGCCCACGTCCCAGCTGGACCATGGCGCCTCCGCGGAACGTG GTGAAGATTGCCATCAAGATGCGTGACGCCATCCCGCAGCTCATCCAGCTGGACCAGGCG AAGCCCCTGGCCGCTGTGCTGAAGGAGGTGTGCGACGCGTGGAGCCTGACGCACTCTGAG CGTTACGCCCTGCAGTTTGCGGATGGGCACCGGAGATACATCACCGAGAATAACCGCGCG GAGATCAAGAATGGCAGCATCCTGTGCCTCAGCACGGCCCCAGACCTTGAGGCTGAGCAG CTCTTGGGTGGGCTGCAGAGTAACAGTCCTGAAGGGCGCCGGGAAGCCCTGAGGCGCCTT GTTCCGCTGGCCTCGGACATGATCTTTGCCAGGGAGGTCATCAGCCGTAATGGGCTCCAG ATACTAGGCACCATCATTGAAGATGGGGACGACCTAGGAGAGGTGCTGGCCCTCAGCCTG AGGGCCTTCTCAGAGCTCATGGAGCACGGCGTGGTGTCCTGGGAGACTCTGAGCATCCCC TTTGTGAGGAAGGTGGTGTGCTACGTGAACATGAACCTCATGGATGCCTCCGTGCCTCCC CTGGCCCTTGGGCTGCTGGAGAGTGTGACCTTGAGCAGCCCAGCCCTGGGCCAGCTGGTC AAGAGCGAGGTGCCCCTGGATAGGCTGCTGGTGCACCTACAGGTGATGAACCAGCAGCTG CAAACCAAGGCCATGGCCCTGCTGACAGCCTTGCTGCAGGGGGCCAGCCCTGTGGAACGC AAGCACATGCTTGACTATCTTTGGCAGAGGAACCTTCGCCAGTTCATCTATAAGAACATC ATCCACAGTGCAGCACCAATGGGCGACGAGATGGCTCATCACCTGTACGTACTGCAGGCT CTCATGCTGGGGCTGCTGGAGCCGCGCATGCGGACGCCCCTGGACCCCTACAGCCAGGAG CAGCGGGAGCAGCTGCAGGTCCTACGCCAGGCTGCCTTCGAGGTGGAGGGGGAGTCCTCG GGTGCCGGGCTAAGTGCTGACCGTCGCCGTTCCCTCTGTGCCCGAGAGTTCCGCAAACTG GGCTTTTCTAACAGCAACCCAGCACAGGACCTGGAGCGCGTGCCCCCCGGTCTGCTGGCC CTGGACAACATGTTGTACTTCTCCAGAAACGCGCCCAGCGCGTACAGCCGGTTTGTGTTG GAGAACAGCAGCCGCGAGGACAAGCACGAGTGCCCCTTTGCCCGGGGCAGCATCCAGCTG ACGGTGCTGCTGTGTGAGCTGCTCCGTGTTGGGGAGCCCTGCTCTGAGACAGCCCAGGAC TTCTCACCCATGTTCTTCGGCCAAGACCAGAGCTTCCACGAGCTCTTCTGTGTGGGCATC CAGCTGTTGAATAAGACCTGGAAGGAGATGCGGGCTACACAGGAGGACTTCGACAAGGTC ATGCAGGTGGTGCGGGAGCAGCTGGCCCGCACTCTGGCCCTGAAGCCCACTTCCCTGGAG CTCTTCCGAACCAAGGTGAATGCGCTCACTTATGGGGAGGTGCTGCGGCTGCGGCAGACT GAACGGCTGCACCAGGAGGGCACACTGGCTCCCCCTATACTGGAGCTGCGGGAGAAGCTG AAGCCAGAGCTCATGGGCCTGATCCGCCAGCAGCGCTTGCTCCGCCTCTGTGAGGGGACG CTCTTCCGCAAGATCAGCAGCCGGCGGCGCCAGGATAAGCTGTGGTTCTGCTGCCTGTCC CCCAACCACAAGCTGCTGCAGTACGGAGACATGGAGGAGGGCGCCAGCCCGCCTACCCTG GAGAGTCTGCCCGAGCAACTCCCTGTGGCCGACATGAGGGCACTCCTGACAGGCAAGGAC TGCCCCCATGTCCGGGAGAAGGGCTCCGGGAAGCAGAACAAGGACCTCTATGAGTTGGCC TTCTCAATCAGCTATGACCGTGGGGAGGAGGAAGCGTACCTCAACTTCATTGCCCCCTCC AAGCGGGAGTTCTACCTGTGGACAGATGGGCTCAGTGCCTTGCTGGGCAGTCCCATGGGC AGCGAGCAGACACGGCTGGACCTGGAGCAGCTGCTGACCATGGAGACCAAGCTGCGTCTG CTGGAGCTGGAGAACGTGCCCATCCCCGAGCGGCCACCCCCTGTGCCCCCACCCCCCACC AACTTCAACTTCTGCTATGACTGCAGCATCGCTGAACCTTGA |
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| Protein Properties | ||||||||||||
| Number of Residues | 720 | |||||||||||
| Molecular Weight | 81466.2 | |||||||||||
| Theoretical pI | 6.23 | |||||||||||
| Pfam Domain Function |
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| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Engulfment and cell motility protein 3 MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRY ITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREV ISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNL MDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQ GASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTP LDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLER VPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEP CSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLA LKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRL LRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMR ALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSA LLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP |
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| External Links | ||||||||||||
| GenBank ID Protein | 87298935 | |||||||||||
| UniProtKB/Swiss-Prot ID | Q96BJ8 | |||||||||||
| UniProtKB/Swiss-Prot Entry Name | ELMO3_HUMAN | |||||||||||
| PDB IDs | Not Available | |||||||||||
| GenBank Gene ID | Not Available | |||||||||||
| GeneCard ID | ELMO3 | |||||||||||
| GenAtlas ID | ELMO3 | |||||||||||
| HGNC ID | HGNC:17289 | |||||||||||
| References | ||||||||||||
| General References | Not Available | |||||||||||