Showing Protein Engulfment and cell motility protein 1 (CDBP05081)
| Identification | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMDB Protein ID | CDBP05081 | |||||||||||||
| Secondary Accession Numbers | Not Available | |||||||||||||
| Name | Engulfment and cell motility protein 1 | |||||||||||||
| Description | Not Available | |||||||||||||
| Synonyms |
|
|||||||||||||
| Gene Name | ELMO1 | |||||||||||||
| Protein Type | Enzyme | |||||||||||||
| Biological Properties | ||||||||||||||
| General Function | Involved in binding | |||||||||||||
| Specific Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 | |||||||||||||
| GO Classification |
|
|||||||||||||
| Cellular Location |
|
|||||||||||||
| Pathways | Not Available | |||||||||||||
| Gene Properties | ||||||||||||||
| Chromosome Location | Chromosome:7 | |||||||||||||
| Locus | 7p14.1 | |||||||||||||
| SNPs | ELMO1 | |||||||||||||
| Gene Sequence |
>2184 bp ATGCCGCCACCCGCGGACATCGTCAAGGTGGCCATAGAATGGCCGGGCGCCTACCCCAAA CTCATGGAAATTGATCAGAAAAAACCACTGTCTGCAATAATAAAGGAAGTCTGTGATGGG TGGTCTCTTGCCAACCATGAATATTTTGCACTCCAGCATGCCGATAGTTCAAACTTCTAT ATCACAGAAAAGAACCGCAATGAGATAAAAAATGGCACTATCCTTCGATTAACCACATCT CCAGCTCAGAACGCCCAGCAGCTCCATGAACGAATCCAGTCCTCGAGTATGGATGCCAAG CTGGAAGCCCTGAAGGACTTGGCCAGCCTCTCCCGGGATGTCACGTTTGCCCAGGAGTTT ATAAACCTGGACGGTATCTCTCTCCTCACGCAGATGGTGGAGAGCGGCACTGAGCGATAC CAGAAATTGCAGAAGATCATGAAGCCTTGCTTTGGAGACATGCTGTCCTTCACCCTGACG GCCTTCGTCGAGCTGATGGACCATGGCATAGTGTCCTGGGATACATTTTCGGTGGCGTTC ATTAAGAAGATAGCAAGTTTTGTGAACAAGTCAGCCATAGACATCTCGATCCTGCAGCGG TCCTTGGCCATTTTGGAGTCGATGGTGCTCAATAGCCATGATCTCTACCAGAAAGTGGCG CAGGAGATCACCATCGGCCAGCTCATTCCACACCTGCAAGGGTCAGATCAAGAAATCCAA ACCTATACTATTGCAGTGATTAATGCGCTTTTCCTGAAGGCTCCTGATGAGAGGAGGCAG GAGATGGCGAATATTTTGGCTCAGAAGCAACTGCGTTCCATCATTTTAACACATGTCATC CGAGCCCAGCGGGCCATCAACAATGAGATGGCGCACCAGCTGTATGTTCTACAAGTGCTC ACCTTTAACCTCCTGGAAGACAGGATGATGACCAAAATGGACCCCCAGGACCAGGCTCAG AGGGACATCATATTTGAACTTCGAAGAATTGCTTTTGATGCTGAGTCTGAACCTAACAAC AGCAGTGGCAGCATGGAGAAACGCAAGTCCATGTACACGCGAGATTATAAGAAGCTTGGG TTCATTAATCATGTCAACCCTGCCATGGACTTCACGCAGACTCCACCTGGGATGTTGGCT CTGGACAACATGCTGTACTTTGCCAAGCACCACCAAGATGCCTACATCCGGATTGTGCTT GAGAACAGTAGTCGAGAAGACAAGCATGAATGTCCCTTTGGCCGCAGTAGTATAGAGCTG ACCAAGATGCTATGTGAGATCTTGAAAGTGGGCGAGTTGCCTAGTGAGACCTGCAACGAC TTCCACCCGATGTTCTTCACCCACGACAGATCCTTTGAGGAGTTTTTCTGCATCTGTATC CAGCTCCTGAACAAGACATGGAAGGAAATGAGGGCAACTTCTGAAGACTTCAACAAGGTA ATGCAGGTGGTGAAGGAGCAGGTTATGAGAGCACTTACAACCAAGCCTAGCTCCCTGGAC CAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCAGTCC GAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATT CAGCCAGAAATCTTAGAGCTGATCAAACAGCAACGCCTGAACCGCCTTGTGGAAGGGACC TGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCTTTCG CCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCC CACGATTCCTTGCAGGACAAACTGCCGGTGGCAGATATCAAAGCCGTGGTGACGGGAAAG GACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGAACTC GCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCAT GAGTACTGTATCTGGACGGATGGACTGAATGCGCTACTCGGGAAGGACATGATGAGCGAC CTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCTGGAC CTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTAT GACTTCGTCTATGACTGTAACTGA |
|||||||||||||
| Protein Properties | ||||||||||||||
| Number of Residues | 727 | |||||||||||||
| Molecular Weight | 83828.6 | |||||||||||||
| Theoretical pI | 6.22 | |||||||||||||
| Pfam Domain Function |
|
|||||||||||||
| Signals |
|
|||||||||||||
| Transmembrane Regions |
|
|||||||||||||
| Protein Sequence |
>Engulfment and cell motility protein 1 MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFY ITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEF INLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAF IKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQ TYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVL TFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLG FINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIEL TKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKV MQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKI QPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVP HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKH EYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNY DFVYDCN |
|||||||||||||
| External Links | ||||||||||||||
| GenBank ID Protein | 16118555 | |||||||||||||
| UniProtKB/Swiss-Prot ID | Q92556 | |||||||||||||
| UniProtKB/Swiss-Prot Entry Name | ELMO1_HUMAN | |||||||||||||
| PDB IDs | Not Available | |||||||||||||
| GenBank Gene ID | AF398885 | |||||||||||||
| GeneCard ID | ELMO1 | |||||||||||||
| GenAtlas ID | ELMO1 | |||||||||||||
| HGNC ID | HGNC:16286 | |||||||||||||
| References | ||||||||||||||
| General References | Not Available | |||||||||||||