| Identification |
|---|
| HMDB Protein ID
| CDBP05081 |
| Secondary Accession Numbers
| Not Available |
| Name
| Engulfment and cell motility protein 1 |
| Description
| Not Available |
| Synonyms
|
- Protein ced-12 homolog
|
| Gene Name
| ELMO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 |
| GO Classification
|
| Component |
| cytoskeleton |
| organelle |
| non-membrane-bounded organelle |
| intracellular non-membrane-bounded organelle |
| Function |
| binding |
| Process |
| cellular process |
| cellular membrane organization |
| membrane invagination |
| endocytosis |
| phagocytosis |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7p14.1 |
| SNPs
| ELMO1 |
| Gene Sequence
|
>2184 bp
ATGCCGCCACCCGCGGACATCGTCAAGGTGGCCATAGAATGGCCGGGCGCCTACCCCAAA
CTCATGGAAATTGATCAGAAAAAACCACTGTCTGCAATAATAAAGGAAGTCTGTGATGGG
TGGTCTCTTGCCAACCATGAATATTTTGCACTCCAGCATGCCGATAGTTCAAACTTCTAT
ATCACAGAAAAGAACCGCAATGAGATAAAAAATGGCACTATCCTTCGATTAACCACATCT
CCAGCTCAGAACGCCCAGCAGCTCCATGAACGAATCCAGTCCTCGAGTATGGATGCCAAG
CTGGAAGCCCTGAAGGACTTGGCCAGCCTCTCCCGGGATGTCACGTTTGCCCAGGAGTTT
ATAAACCTGGACGGTATCTCTCTCCTCACGCAGATGGTGGAGAGCGGCACTGAGCGATAC
CAGAAATTGCAGAAGATCATGAAGCCTTGCTTTGGAGACATGCTGTCCTTCACCCTGACG
GCCTTCGTCGAGCTGATGGACCATGGCATAGTGTCCTGGGATACATTTTCGGTGGCGTTC
ATTAAGAAGATAGCAAGTTTTGTGAACAAGTCAGCCATAGACATCTCGATCCTGCAGCGG
TCCTTGGCCATTTTGGAGTCGATGGTGCTCAATAGCCATGATCTCTACCAGAAAGTGGCG
CAGGAGATCACCATCGGCCAGCTCATTCCACACCTGCAAGGGTCAGATCAAGAAATCCAA
ACCTATACTATTGCAGTGATTAATGCGCTTTTCCTGAAGGCTCCTGATGAGAGGAGGCAG
GAGATGGCGAATATTTTGGCTCAGAAGCAACTGCGTTCCATCATTTTAACACATGTCATC
CGAGCCCAGCGGGCCATCAACAATGAGATGGCGCACCAGCTGTATGTTCTACAAGTGCTC
ACCTTTAACCTCCTGGAAGACAGGATGATGACCAAAATGGACCCCCAGGACCAGGCTCAG
AGGGACATCATATTTGAACTTCGAAGAATTGCTTTTGATGCTGAGTCTGAACCTAACAAC
AGCAGTGGCAGCATGGAGAAACGCAAGTCCATGTACACGCGAGATTATAAGAAGCTTGGG
TTCATTAATCATGTCAACCCTGCCATGGACTTCACGCAGACTCCACCTGGGATGTTGGCT
CTGGACAACATGCTGTACTTTGCCAAGCACCACCAAGATGCCTACATCCGGATTGTGCTT
GAGAACAGTAGTCGAGAAGACAAGCATGAATGTCCCTTTGGCCGCAGTAGTATAGAGCTG
ACCAAGATGCTATGTGAGATCTTGAAAGTGGGCGAGTTGCCTAGTGAGACCTGCAACGAC
TTCCACCCGATGTTCTTCACCCACGACAGATCCTTTGAGGAGTTTTTCTGCATCTGTATC
CAGCTCCTGAACAAGACATGGAAGGAAATGAGGGCAACTTCTGAAGACTTCAACAAGGTA
ATGCAGGTGGTGAAGGAGCAGGTTATGAGAGCACTTACAACCAAGCCTAGCTCCCTGGAC
CAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCAGTCC
GAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATT
CAGCCAGAAATCTTAGAGCTGATCAAACAGCAACGCCTGAACCGCCTTGTGGAAGGGACC
TGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCTTTCG
CCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCC
CACGATTCCTTGCAGGACAAACTGCCGGTGGCAGATATCAAAGCCGTGGTGACGGGAAAG
GACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGAACTC
GCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCAT
GAGTACTGTATCTGGACGGATGGACTGAATGCGCTACTCGGGAAGGACATGATGAGCGAC
CTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCTGGAC
CTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTAT
GACTTCGTCTATGACTGTAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 727 |
| Molecular Weight
| 83828.6 |
| Theoretical pI
| 6.22 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Engulfment and cell motility protein 1
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFY
ITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEF
INLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAF
IKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQ
TYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVL
TFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLG
FINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIEL
TKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKV
MQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKI
QPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVP
HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKH
EYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNY
DFVYDCN
|
| External Links |
|---|
| GenBank ID Protein
| 16118555 |
| UniProtKB/Swiss-Prot ID
| Q92556 |
| UniProtKB/Swiss-Prot Entry Name
| ELMO1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF398885 |
| GeneCard ID
| ELMO1 |
| GenAtlas ID
| ELMO1 |
| HGNC ID
| HGNC:16286 |
| References |
|---|
| General References
| Not Available |