| Identification |
|---|
| HMDB Protein ID
| CDBP05078 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prolactin regulatory element-binding protein |
| Description
| Not Available |
| Synonyms
|
- Mammalian guanine nucleotide exchange factor mSec12
|
| Gene Name
| PREB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Endoplasmic reticulum membrane
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p23.3 |
| SNPs
| PREB |
| Gene Sequence
|
>1254 bp
ATGGGCCGGCGCCGGGCGCCAGAGCTGTACCGGGCTCCGTTCCCGTTGTACGCGCTTCAG
GTCGACCCCAGCACTGGGCTGCTCATCGCTGCGGGCGGAGGAGGCGCCGCCAAGACAGGC
ATAAAGAATGGCGTGCACTTTCTGCAGCTAGAGCTGATTAATGGGCGCTTGAGTGCCTCC
TTGCTGCACTCCCATGACACAGAGACACGGGCCACCATGAACTTGGCACTGGCTGGTGAC
ATCCTTGCTGCAGGGCAGGATGCACACTGTCAGCTCCTGCGCTTCCAGGCACATCAACAG
CAGGGCAACAAGGCAGAGAAGGCCGGTTCCAAGGAGCAGGGGCCTCGACAAAGGAAGGGA
GCAGCCCCAGCAGAGAAGAAATGTGGAGCGGAAACCCAGCACGAGGGGCTAGAACTCAGG
GTAGAGAATTTGCAGGCGGTGCAGACAGACTTTAGCTCCGATCCACTGCAGAAAGTTGTG
TGCTTCAACCACGATAATACCCTGCTTGCCACTGGAGGAACAGATGGCTACGTCCGTGTC
TGGAAGGTGCCCAGCCTGGAGAAGGTTCTGGAGTTCAAAGCCCACGAAGGGGAGATTGAA
GACCTGGCTTTAGGGCCTGATGGCAAGTTGGTAACCGTGGGCCGGGACCTTAAGGCCTCT
GTGTGGCAGAAGGATCAGCTGGTGACACAGCTGCACTGGCAAGAAAATGGACCCACCTTT
TCCAGCACACCTTACCGCTACCAGGCCTGCAGGTTTGGGCAGGTTCCAGACCAGCCTGCT
GGCCTGCGACTCTTCACAGTGCAAATTCCCCACAAGCGGCTGCGGCAGCCCCCTCCCTGC
TACCTCACAGCCTGGGATGGCTCCAACTTCTTGCCCCTTCGGACCAAGTCCTGTGGCCAT
GAAGTCGTCTCCTGCCTCGATGTCAGTGAATCCGGCACCTTCCTAGGCCTGGGCACAGTC
ACTGGCTCTGTTGCCATCTACATAGCTTTCTCTCTCCAGTGCCTCTACTACGTGAGGGAG
GCCCATGGCATTGTGGTGACGGATGTGGCCTTTCTACCTGAGAAGGGTCGTGGTCCAGAG
CTCCTTGGGTCCCATGAAACTGCCCTGTTCTCTGTGGCTGTGGACAGTCGTTGCCAGCTG
CATCTGTTGCCCTCACGGCGGAGTGTTCCTGTGTGGCTCCTGCTCCTGCTGTGTGTCGGG
CTTATTATTGTGACCATCCTGCTGCTCCAGAGTGCCTTTCCAGGTTTCCTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 417 |
| Molecular Weight
| 45467.8 |
| Theoretical pI
| 7.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Prolactin regulatory element-binding protein
MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSAS
LLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKG
AAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRV
WKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTF
SSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGH
EVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPE
LLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL
|
| External Links |
|---|
| GenBank ID Protein
| 6606522 |
| UniProtKB/Swiss-Prot ID
| Q9HCU5 |
| UniProtKB/Swiss-Prot Entry Name
| PREB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF203687 |
| GeneCard ID
| PREB |
| GenAtlas ID
| PREB |
| HGNC ID
| HGNC:9356 |
| References |
|---|
| General References
| Not Available |