| Identification |
|---|
| HMDB Protein ID
| CDBP05075 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho guanine nucleotide exchange factor 10-like protein |
| Description
| Not Available |
| Synonyms
|
- GrinchGEF
|
| Gene Name
| ARHGEF10L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.13 |
| SNPs
| ARHGEF10L |
| Gene Sequence
|
>3840 bp
ATGGCTTCCTCCAACCCTCCTCCACAGCCTGCCATAGGAGATCAGCTGGTTCCAGGAGTC
CCAGGCCCCTCCTCTGAGGCAGAGGACGACCCAGGAGAGGCGTTTGAGTTTGATGACAGT
GATGATGAAGAGGACACCAGCGCAGCCCTGGGCGTCCCCAGCCTTGCTCCTGAGAGGGAC
ACAGACCCCCCACTGATCCACTTGGACTCCATCCCTGTCACTGACCCAGACCCAGCAGCT
GCTCCACCCGGCACAGGGGTGCCAGCCTGGGTGAGCAATGGGGATGCAGCGGACGCAGCC
TTCTCCGGGGCCCGGCACTCCAGCTGGAAGCGGAAGAGTTCCCGTCGCATTGACCGGTTC
ACTTTCCCCGCCCTGGAAGAGGATGTGATTTATGACGACGTCCCCTGCGAGAGCCCAGAT
GCGCATCAGCCCGGGGCAGAGAGGAACCTGCTCTACGAGGATGCGCACCGGGCTGGGGCC
CCTCGGCAGGCGGAGGACCTAGGCTGGAGCTCCAGTGAGTTCGAGAGCTACAGCGAGGAC
TCGGGGGAGGAGGCCAAGCCGGAGGTCGAGGTCGAGCCCGCCAAGCACCGAGTGTCCTTC
CAGCCCAAGCTTTCTCCAGACCTGACTAGGCTAAAGGAGAGATACGCCAGGACTAAGAGA
GACATCTTGGCTTTGAGAGTTGGGGGGAGAGACATGCAGGAGCTGAAGCACAAGTACGAT
TGTAAGATGACCCAGCTCATGAAGGCCGCCAAGAGCGGGACCAAGGATGGGCTGGAGAAG
ACACGGATGGCCGTGATGCGCAAAGTCTCCTTCCTGCACAGGAAGGACGTCCTCGGTGAC
TCGGAGGAGGAGGACATGGGGCTCCTGGAGGTCAGCGTTTCGGACATCAAGCCCCCAGCC
CCAGAGCTGGGCCCCATGCCAGAGGGCCTGAGCCCTCAGCAGGTGGTCCGGAGGCATATC
CTGGGCTCCATCGTGCAGAGCGAAGGCAGCTACGTGGAGTCTCTGAAGCGGATACTCCAG
GACTACCGCAACCCCCTGATGGAGATGGAGCCCAAGGCGCTGAGCGCCCGCAAGTGCCAG
GTGGTGTTCTTCCGCGTGAAGGAGATCCTGCACTGCCACTCCATGTTCCAGATCGCCCTG
TCCTCCCGCGTGGCTGAGTGGGATTCCACCGAGAAGATCGGGGACCTCTTCGTGGCCTCG
TTTTCCAAGTCCATGGTGCTAGATGTGTACAGTGACTACGTGAACAACTTCACCAGTGCC
ATGTCCATCATCAAGAAGGCCTGCCTCACCAAGCCTGCCTTCCTCGAGTTCCTCAAGCGA
CGGCAGGTGTGCAGCCCAGACCGTGTCACCCTCTACGGGCTGATGGTCAAGCCCATCCAG
AGGTTCCCACAGTTCATACTCCTGCTTCAGGACATGCTGAAGAACACCCCCAGGGGCCAT
CCGGACAGGCTGTCGCTGCAGCTGGCCCTCACAGAGCTGGAGACGCTGGCTGAGAAGCTG
AACGAGCAGAAGCGGCTGGCTGACCAGGTGGCTGAGATCCAGCAGCTGACCAAGAGCGTC
AGTGACCGCAGCAGCCTCAACAAGCTGTTGACCTCAGGCCAGCGGCAGCTGCTCCTGTGT
GAGACGTTGACGGAGACCGTGTACGGTGACCGCGGGCAGCTAATTAAGTCCAAGGAGCGT
CGGGTCTTCCTGCTCAACGACATGCTTGTCTGTGCCAACATCAACTTCAAGCCTGCCAAC
CACAGGGGCCAGCTGGAGATCAGCAGCCTGGTGCCCCTGGGGCCCAAGTATGTGGTGAAG
TGGAACACGGCGCTGCCCCAGGTGCAGGTGGTGGAGGTGGGCCAGGACGGTGGCACCTAT
GACAAGGACAATGTGCTCATCCAGCACTCAGGCGCCAAGAAGGCCTCTGCCTCAGGGCAG
GCTCAGAATAAGGTGTACCTCGGCCCCCCACGCCTCTTCCAGGAGCTGCAGGACCTGCAG
AAGGACCTGGCCGTGGTGGAGCAGATCACGCTTCTCATCAGCACGCTGCACGGCACCTAC
CAGAACCTGAACATGACTGTGGCTCAAGACTGGTGCCTGGCCCTGCAGAGGCTGATGCGG
GTGAAGGAGGAAGAGATCCACTCGGCCAACAAGTGCCGTCTCAGGCTCCTGCTTCCTGGG
AAACCCGACAAGTCCGGCCGCCCCATTAGCTTCATGGTGGTTTTCATCACCCCCAACCCC
CTGAGCAAGATTTCCTGGGTCAACAGGTTACATTTGGCCAAAATCGGACTCCGGGAGGAG
AACCAGCCAGGCTGGCTATGCCCGGATGAGGACAAGAAGAGCAAAGCCCCATTCTGGTGC
CCGATCCTGGCCTGCTGCATCCCTGCCTTCTCCTCCCGGGCACTCAGCCTGCAGCTTGGG
GCCCTGGTCCACAGTCCTGTCAACTGTCCCCTGCTGGGTTTCTCAGCAGTCAGCACCTCC
CTTCCACAGGGCTACCTCTGGGTCGGGGGCGGACAGGAAGGCGCAGGGGGCCAGGTGGAA
ATCTTTTCCTTGAACCGGCCCTCGCCCCGCACCGTCAAGTCCTTCCCACTGGCAGCCCCT
GTGCTCTGCATGGAGTATATCCCGGAGCTGGAGGAGGAGGCGGAGAGCAGAGACGAGAGC
CCGACAGTTGCTGACCCCTCGGCCACGGTGCATCCAACCATCTGCCTCGGGCTCCAGGAT
GGCAGCATCCTCCTCTACAGCAGTGTGGACACTGGCACCCAGTGCCTGGTGAGCTGCAGG
AGCCCAGGTCTGCAGCCTGTGCTCTGCCTGCGACACAGCCCCTTCCACCTGCTCGCTGGC
CTGCAGGATGGGACCCTTGCTGCTTACCCTCGGACCAGCGGAGGTGTCCTGTGGGACCTG
GAGAGCCCTCCCGTGTGCCTGACTGTGGGGCCCGGGCCTGTCCGCACCCTGTTGAGCCTG
GAGGATGCCGTGTGGGCCAGCTGTGGGCCCCGGGTCACTGTCCTGGAAGCCACCACCCTG
CAGCCTCAGCAAAGCTTCGAGGCGCACCAGGACGAGGCAGTGAGCGTGACACACATGGTG
AAGGCGGGCAGCGGCGTCTGGATGGCCTTCTCCTCCGGCACCTCCATCCGCCTCTTCCAC
ACTGAGACCCTGGAGCATCTGCAAGAGATCAACATCGCCACCAGGACCACCTTCCTCCTG
CCAGGCCAGAAGCACTTGTGTGTCACCAGCCTCCTGATCTGCCAGGGTCTGCTCTGGGTG
GGCACTGACCAGGGTGTCATCGTCCTGCTGCCCGTGCCTCGGCTGGAAGGCATCCCCAAG
ATCACAGGGAAAGGCATGGTCTCACTCAACGGGCACTGTGGGCCTGTGGCCTTCCTGGCT
GTGGCTACCAGCATCCTGGCCCCTGACATCCTGCGGAGTGACCAGGAGGAGGCTGAGGGG
CCCCGGGCTGAGGAGGACAAGCCAGACGGGCAGGCACACGAGCCCATGCCCGATAGCCAC
GTGGGCCGAGAGCTGACCCGCAAGAAGGGCATCCTCTTGCAGTACCGCCTGCGCTCCACC
GCACACCTCCCGGGCCCGCTGCTCTCCATGCGGGAGCCGGCGCCTGCTGATGGCGCAGCT
TTGGAGCACAGCGAGGAGGACGGCTCCATTTACGAGATGGCCGACGACCCCGACATCTGG
GTGCGCAGCCGGCCCTGCGCCCGCGACGCCCACCGCAAGGAGATTTGCTCTGTGGCCATC
ATCTCCGGCGGGCAGGGCTACCGCAACTTTGGCAGCGCTCTGGGCAGCAGTGGGAGGCAG
GCCCCGTGTGGGGAGACGGACAGCACCCTCCTCATCTGGCAGGTGCCCTTGATGCTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1279 |
| Molecular Weight
| 140363.9 |
| Theoretical pI
| 5.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho guanine nucleotide exchange factor 10-like protein
MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD
CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA
PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ
VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA
MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH
PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC
ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK
WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ
KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG
KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC
PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE
IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL
ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV
KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV
GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG
PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA
LEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ
APCGETDSTLLIWQVPLML
|
| External Links |
|---|
| GenBank ID Protein
| 58761492 |
| UniProtKB/Swiss-Prot ID
| Q9HCE6 |
| UniProtKB/Swiss-Prot Entry Name
| ARGAL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018125.3 |
| GeneCard ID
| ARHGEF10L |
| GenAtlas ID
| ARHGEF10L |
| HGNC ID
| HGNC:25540 |
| References |
|---|
| General References
| Not Available |