Identification
HMDB Protein ID CDBP05072
Secondary Accession Numbers Not Available
Name Rho guanine nucleotide exchange factor 11
Description Not Available
Synonyms
  1. PDZ-RhoGEF
Gene Name ARHGEF11
Protein Type Enzyme
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13
GO Classification
Component
cell part
intracellular part
cytoplasm
intracellular
Function
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
protein binding
molecular transducer activity
signal transducer activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
small gtpase regulator activity
Process
regulation of small gtpase mediated signal transduction
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
Cellular Location
  1. Cytoplasm
  2. Membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q21
SNPs ARHGEF11
Gene Sequence
>4569 bp
ATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTAAGTAGCCTGTCTTCTCTGGGAGAT
TCTGCACCAGAGCGCAAGTCCCCTTCCCACCATCGCCAGCCTTCGGATGCCTCTGAGACA
ACAGGTCTCGTTCAACGCTGTGTCATTATCCAAAAGGACCAGCATGGCTTCGGCTTCACA
GTCAGTGGGGATCGCATTGTTCTGGTGCAGTCTGTGCGGCCTGGAGGTGCAGCCATGAAG
GCCGGTGTGAAAGAGGGCGACCGGATCATCAAAGTCAACGGCACCATGGTGACCAATAGC
TCACACCTGGAAGTGGTAAAGCTGATCAAATCTGGCGCCTATGTCGCACTCACCCTCCTG
GGCTCTTCACCTTCATCCATGGGCATCTCTGGGCTCCAGCAGGACCCATCCCCAGCAGGA
GCTCCCCGAATCACGTCAGTGATCCCCTCACCACCACCTCCTCCACCTCTACCACCTCCA
CAACGCATCACAGGACCCAAACCTCTGCAGGATCCCGAAGTTCAAAAACATGCCACCCAG
ATCCTCAGGAATATGCTGAGGCAGGAAGAAAAAGAATTACAGGACATACTTCCACTATAT
GGTGACACCAGCCAGAGACCATCAGAAGGCCGGCTCTCTCTGGATTCCCAGGAGGGGGAC
AGTGGCTTGGACTCTGGGACAGAACGCTTTCCTTCCCTCAGTGAGTCATTGATGAATCGG
AACTCGGTACTGTCAGACCCTGGGCTAGACAGTCCTCGAACCTCCCCTGTGATCATGGCC
AGGGTGGCCCAGCACCACAGGCGGCAGGGCTCGGATGCAGCAGTCCCCTCAACCGGTGAC
CAGGGTGTAGATCAAAGCCCAAAGCCTTTAATTATTGGCCCAGAGGAAGACTATGACCCG
GGTTATTTCAACAACGAGAGCGACATCATATTCCAGGATCTGGAGAAACTGAAGTCTCGG
CCAGCTCACCTGGGGGTTTTTCTACGTTACATCTTCTCTCAGGCGGACCCCAGTCCACTG
CTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGCTTG
GGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCT
GAGATGCTACAGGCTGAAATTGACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTT
CTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTACAGA
ACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGAT
GGGGACCCTCTCCGAGAGCGCCAAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATT
TTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATG
AGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAG
TCTGCTCCTGACAAGGACAAGTGGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAAT
TCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATT
GGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTC
AAACCAGGCAATGTGAGGAACATCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCC
CCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGT
GACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAG
ATGAAACGGTCTCGAAAGGCAGAGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGAT
GCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTCTCC
ACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATT
GAGTCCCCCAGTTTGGGGTTCTGCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGAT
CTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACAGTG
GGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAAT
GAGCTGTTTGTGACTGAAGCTTCCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTC
TACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCG
AACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGG
GAGGAAGGCCCCATCATCAAAGAGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCT
GCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTA
GAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCT
GAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAG
CGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACC
TCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTG
AATGAAGCGGTAAAACAAACAGAGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTG
GATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTGGAT
CTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAG
ACCTTGGACCTCCACGTGCTGCTGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGAT
GAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAGCAG
ACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAA
CGGGCCTTCTTCATCATCTGCACCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTT
GCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAAT
GCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGG
GAGCCAGCCCAGCAGGGCCCCACACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTC
CATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAA
GGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAA
CTGGGTGTCCTGCCTTGCCCTTCCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACA
AGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCC
GCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCAC
ACCATGGAAACTCAGGCTGCCCAGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTC
ATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGGGGT
GAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATG
GGTCTCTGTTCTCTGGAACACCTACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCT
CCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGTTAC
AAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGT
GGCCAGTCAGAGCCTGGGCCACCTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGC
TTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCC
ATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTG
CAGGGAGGCAACGATGATCCAAGACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGG
GACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAG
GATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGC
ACCACGCCTGTGGGCAGTTTCCACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCA
CCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGC
CCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCA
GGACCATAA
Protein Properties
Number of Residues 1522
Molecular Weight 167702.8
Theoretical pI 5.18
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Rho guanine nucleotide exchange factor 11
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR
NSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDP
GYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSL
GKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR
TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYM
SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYI
GKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLES
DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLS
TRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV
GKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFP
NLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL
ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT
SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD
LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ
TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN
ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ
GKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADS
ALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGG
EGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY
KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP
MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLK
DMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPC
PEDGSDAPLEDSTADAAASPGP
GenBank ID Protein 7662086
UniProtKB/Swiss-Prot ID O15085
UniProtKB/Swiss-Prot Entry Name ARHGB_HUMAN
PDB IDs
GenBank Gene ID NM_014784.2
GeneCard ID ARHGEF11
GenAtlas ID ARHGEF11
HGNC ID HGNC:14580
References
General References Not Available