| Identification |
|---|
| HMDB Protein ID
| CDBP05067 |
| Secondary Accession Numbers
| Not Available |
| Name
| Probable guanine nucleotide exchange factor MCF2L2 |
| Description
| Not Available |
| Synonyms
|
- Dbs-related Rho family guanine nucleotide exchange factor
- MCF2-transforming sequence-like protein 2
|
| Gene Name
| MCF2L2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Probably functions as a guanine nucleotide exchange factor |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q27.1 |
| SNPs
| MCF2L2 |
| Gene Sequence
|
>3345 bp
ATGCTGTCTTGCTTAAAAGAAGAGATGCCTCCCCAGGAGCTCACCCGGCGACTGGCCACA
GTGATCACTCATGTCGATGAAATTATGCAGCAGGAAGTCAGACCCCTGATGGCGGTGGAG
ATAATAGAACAACTTCACAGACAATTTGCCATTCTTTCAGGAGGCCGAGGGGAGGATGGC
GCCCCCATCATCACGTTCCCAGAGTTTTCGGGGTTCAAACACATCCCAGATGAAGACTTC
CTGAATGTCATGACCTACCTGACTAGCATCCCCAGTGTGGAGGCTGCCAGCATTGGATTC
ATTGTTGTTATCGACAGACGAAGAGACAAGTGGAGCTCCGTAAAGGCATCCTTGACACGA
ATAGCTGTGGCATTTCCAGGAAACTTACAGCTCATATTCATCCTTCGTCCATCTCGCTTT
ATCCAGAGGACATTCACTGACATTGGCATTAAATACTATCGAAATGAGTTTAAAACGAAA
GTGCCGATCATCATGGTAAACTCTGTCTCTGACCTTCACGGCTACATCGACAAAAGCCAA
CTGACCCGGGAATTAGGGGGGACTTTGGAATATCGCCACGGTCAGTGGGTAAATCACCGC
ACTGCCATCGAAAACTTTGCCTTGACCTTGAAGACCACTGCCCAGATGCTGCAGACGTTT
GGGTCCTGCCTGGCCACAGCAGAGCTGCCCAGAAGCATGCTATCCACGGAAGACCTTCTC
ATGTCCCACACAAGGCAGCGGGACAAGCTGCAGGATGAGCTGAAATTACTTGGAAAGCAG
GGGACCACATTGCTGTCATGCATCCAAGAACCAGCAACCAAATGTCCCAACAGCAAACTC
AATCTCAACCAACTTGAGAATGTAACTACCATGGAAAGGTTATTAGTTCAACTGGATGAA
ACAGAAAAAGCCTTTAGTCACTTTTGGTCTGAGCATCATCTGAAGCTTAACCAGTGCCTA
CAACTACAGCATTTTGAGCACGATTTTTGTAAGGCTAAGCTTGCCCTGGATAATTTGCTG
GAAGAGCAAGCAGAGTTTACAGGCATTGGAGACAGCGTGATGCACGTGGAGCAGATTCTT
AAGGAACACAAAAAACTGGAGGAAAAAAGCCAGGAGCCCCTGGAAAAGGCCCAGCTGCTG
GCACTGGTTGGGGACCAGCTCATCCAAAGCCACCATTATGCAGCAGATGCCATCAGGCCC
CGGTGTGTGGAGCTCAGGCACCTCTGTGACGATTTCATCAATGGAAACAAGAAAAAATGG
GACATTTTAGGAAAGTCCTTAGAGTTTCATAGACAGCTGGACAAGGTCAGCCAATGGTGT
GAGGCAGGAATCTACCTCTTGGCTTCCCAAGCTGTAGACAAGTGCCAGTCTCGAGAAGGG
GTTGATATCGCCTTGAACGACATTGCGACATTCCTGGGCACAGTCAAGGAGTACCCGTTG
CTCAGCCCCAAGGAGTTTTACAACGAGTTTGAGTTGCTGCTCACCCTCGATGCAAAGGCC
AAAGCCCAGAAAGTTTTGCAGAGGCTGGATGATGTCCAGGAAATATTTCACAAGAGGCAA
GTGAGTCTGATGAAACTGGCAGCCAAACAGACTCGTCCAGTGCAACCTGTGGCCCCACAT
CCTGAGTCTTCACCAAAATGGGTGTCATCAAAAACCAGCCAGCCCTCCACCTCGGTCCCT
CTAGCTCGTCCTCTGAGAACGTCTGAGGAACCTTATACGGAGACAGAGTTGAACTCCCGG
GGAAAGGAAGATGATGAGACTAAATTTGAAGTCAAGAGTGAAGAAATCTTTGAAAGCCAT
CATGAAAGGGGGAACCCTGAGCTGGAGCAGCAGGCCAGGCTCGGAGACCTTTCCCCCCGC
AGGCGCATTATACGTGACTTGCTTGAGACTGAAGAGATTTACATAAAAGAGATTAAAAGC
ATAATTGATGGATATATCACTCCAATGGATTTTATTTGGCTAAAGCATCTAATTCCAGAT
GTTCTTCAGAATAACAAGGACTTTCTCTTTGGGAATATTAGAGAACTTTACGAATTTCAC
AACAGGACTTTTCTAAAAGAGTTGGAAAAGTGTGCTGAGAACCCTGAACTTCTGGCACAT
TGCTTTCTCAAGAGAAAAGAAGATCTTCAGATATATTTTAAATACCATAAGAATCTGCCC
CGAGCTAGGGCAATCTGGCAAGAGTGTCAAGACTGCGCCTACTTTGGGGTATGCCAGCGC
CAACTGGATCACAATCTCCCTCTTTTTAAGTATCTCAAAGGACCAAGCCAGAGACTTATA
AAATACCAGATGCTGTTGAAGGGTCTGCTGGATTTCGAGTCTCCTGAAGATATGGAGATA
GACCCAGGTGAACTAGGAGGCTCGGCTAAGGATGGGCCAAAGAGAACCAAAGATTCAGCA
TTCTCAACTGAACTACAACAAGCTTTGGCAGTGATAGAGGATTTGATCAAGTCCTGTGAG
TTGGCTGTGGACCTAGCAGCAGTGACTGAATGTCCGGACGATATTGGAAAACTAGGCAAG
CTGTTGCTGCACGGCCCTTTCAGCGTCTGGACAATTCACAAGGATCGTTATAAAATGAAG
GATTTGATTCGATTTAAACCCAGCCAGAGGCAAATCTACCTATTTGAAAGGGGAATAGTG
TTCTGTAAGATACGAATGGAGCCTGGGGACCAGGGATTATCTCCTCATTACAGCTTCAAG
AAGACCATGAAGCTGATGACACTTTCAATTCGCCAGCTTGGAAGGGGGAGCCATAGAAAG
TTTGAGATTGCCAGTCGAAATGGACTTGAGAAATACATCCTGCAGGCAGCTTCAAAAGAA
ATCAGAGACTGTTGGTTTTCAGAAATAAGTAAATTATTGATGGAACAACAAAATAATATC
AAAGACCAAGGAAATCCACAGTTTGAAATGAGCACGAGCAAAGGCAGTGGAGCAGGATCC
GGACCATGGATTAAAAATATGGAAAGAGCTACCACTAGCAAGGAAGACCCGGCCTCCAGC
ACAGGAGGGATTAAAGGCTGCTCCAGCAGGGAGTTTAGCTCCATGGACACCTTTGAAGAC
TGTGAAGGCGCAGAAGACATGGAAAAGGAGAGCAGTGCTCTGAGTCTCGCGGGCCTTTTC
CAGTCGGACGACAGTCACGAAACCTGTTCCTCCAAATCTGCTTTCCTGGAGAGGGGAGAA
AGCAGCCAGGGAGAAAAAGAAGAACGCGATGAGGAGGAAACGGCGACCCGCAGCACCGAG
GAGGAGCGCGCTGGGGCGTCCACGGGCCGGCTGGCTCCTGCGGGGGCGACGGCTGGTTTC
CAGGCGAGGGCGCTGCGCCCGAGGACCTCCGCCCAGGAGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1114 |
| Molecular Weight
| 126961.6 |
| Theoretical pI
| 6.37 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Probable guanine nucleotide exchange factor MCF2L2
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG
APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTR
IAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ
LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL
MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE
TEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL
KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW
DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPL
LSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH
PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH
HERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD
VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP
RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI
DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK
LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK
KAMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNI
KDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFED
CEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTE
EERAGASTGRLAPAGATAGFQARALRPRTSAQES
|
| External Links |
|---|
| GenBank ID Protein
| 31742505 |
| UniProtKB/Swiss-Prot ID
| Q86YR7 |
| UniProtKB/Swiss-Prot Entry Name
| MF2L2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015078.2 |
| GeneCard ID
| MCF2L2 |
| GenAtlas ID
| MCF2L2 |
| HGNC ID
| HGNC:30319 |
| References |
|---|
| General References
| Not Available |