| Identification |
|---|
| HMDB Protein ID
| CDBP05063 |
| Secondary Accession Numbers
| Not Available |
| Name
| FERM, RhoGEF and pleckstrin domain-containing protein 2 |
| Description
| Not Available |
| Synonyms
|
- FERM domain including RhoGEF
- FIR
- PH domain-containing family C member 3
- Pleckstrin homology domain-containing family C member 3
|
| Gene Name
| FARP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton |
| GO Classification
|
| Component |
| intracellular non-membrane-bounded organelle |
| cell part |
| intracellular part |
| cytoplasm |
| cytoskeleton |
| membrane part |
| organelle |
| extrinsic to membrane |
| intracellular |
| non-membrane-bounded organelle |
| Function |
| small gtpase regulator activity |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| protein binding |
| cytoskeletal protein binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q37.3 |
| SNPs
| FARP2 |
| Gene Sequence
|
>3165 bp
ATGGGGGAGATAGAAGGAACATACAGAGTCCTGCAGACTGCAGGGATGCGCTTGGGTGCC
CAGACCCCTGTGGGAGTTAGCACCCTTGAGCCTGGGCAGACTCTCTTGCCCAGAATGCAA
GAGAAGCACCTGCACCTCAGAGTAAAGCTGCTGGACAACACCATGGAAATATTTGACATT
GAGCCTAAATGCGATGGCCAGGTATTACTGACACAAGTGTGGAAGCGTTTAAACCTGGTA
GAATGTGACTACTTCGGGATGGAGTTTCAAAATACTCAGTCCTACTGGATTTGGCTTGAA
CCTATGAAACCCATCATTAGGCAAATACGAAGGCCAAAGAATGTGGTGCTTCGCCTAGCT
GTAAAATTTTTTCCACCTGATCCTGGTCAGCTACAAGAAGAATATACAAGATACTTGTTT
GCCTTGCAACTTAAGAGAGACCTGCTGGAAGAGCGTTTGACCTGTGCTGACACCACAGCG
GCCCTTCTCACGTCCCATCTCCTGCAGTCGGAAATAGGAGATTACGATGAAACGCTGGAC
CGAGAGCACCTCAAAGTGAACGAGTATTTGCCTGGCCAGCAGCACTGCCTTGAGAAGATA
CTAGAATTCCATCAGAAGCACGTGGGCCAGACACCTGCTGAGTCGGATTTCCAGGTGCTC
GAAATTGCTCGAAAGTTGGAAATGTACGGCATCAGATTTCACATGGCTTCTGACAGGGAA
GGAACCAAGATTCAACTGGCAGTTTCCCACATGGGTGTACTCGTGTTCCAGGGCACCACC
AAAATCAACACTTTCAACTGGTCCAAGGTCCGTAAACTAAGCTTCAAGAGGAAAAGATTT
CTTATCAAACTTCATCCAGAGGTTCATGGACCTTACCAGGACACATTAGAATTTTTGTTG
GGTAGTAGAGATGAATGTAAGAACTTCTGGAAGATTTGTGTGGAGTATCACACCTTTTTT
AGACTTTTGGACCAACCTAAGCCAAAAGCAAAAGCCGTCTTCTTCAGCCGGGGCTCCTCC
TTCAGATACAGTGGAAGAACTCAGAAACAACTAGTAGATTATTTCAAAGACAGTGGAATG
AAGAGAATTCCATATGAAAGAAGGCACAGCAAGACCCACACGTCCGTTCGAGCTCTGACT
GCAGACCTACCAAAACAGAGCATCTCATTCCCCGAGGGATTGAGGACTCCTGCCTCCCCA
TCTTCAGCGAATGCCTTTTACTCGCTCTCTCCCTCCACTCTGGTCCCCTCTGGCCTGCCA
GAGTTTAAGGACAGCAGCAGCTCCCTCACAGATCCCCAGGTTTCCTACGTCAAGAGTCCA
GCTGCAGAGAGGCGCAGTGGAGCAGTGGCTGGAGGCCCCGACACACCATCGGCCCAGCCC
CTCGGGCCCCCCGCACTCCAGCCTGGTCCAGGCCTTTCCACGAAGAGTCCTCAGCCTTCT
CCCTCCAGCCGGAAGAGCCCCCTGAGTCTGAGCCCTGCATTTCAGGTGCCTTTGGGCCCA
GCTGAACAGGGCTCATCCCCACTCCTGAGCCCTGTCCTCAGTGATGCTGGCGGAGCCGGG
ATGGACTGCGAGGAGCCCAGACACAAGCGCGTGCCTGCAGACGAGGCCTACTTCATAGTC
AAAGAGATTCTCGCTACAGAACGAACATACCTCAAGGATTTAGAAGTTATTACCGTGTGG
TTCCGCAGCGCAGTGGTGAAGGAGGACGCCATGCCTGCGACTCTGATGACGCTGCTCTTC
TCCAACATCGATCCCATCTATGAGTTCCACAGAGGCTTCCTGCGCGAGGTGGAGCAGAGG
CTGGCACTCTGGGAAGGGCCCTCCAAAGCCCACACAAAAGGCAGTCATCAACGAATCGGG
GACATCCTGCTCAGGAACATGCGCCAGTTAAAGGAGTTTACCAGCTACTTCCAAAGACAT
GACGAGGTCCTAACAGAACTGGAAAAGGCTACCAAACGCTGTAAGAAGTTGGAGGCAGTG
TACAAGGAGTTTGAGCTGCAGAAGGTCTGCTACTTGCCTCTCAACACGTTCCTGCTGAAG
CCCATCCAGCGGCTGCTGCACTACCGCCTGCTGCTGCGCCGCCTATGCGGACATTACAGC
CCCGGGCACCATGACTACGCTGACTGCCATGACGCCCTGAAAGCCATCACAGAGGTGACC
ACCACACTACAGCACATTCTCATCCGGCTGGAGAACCTGCAGAAGCTAACGGAGCTGCAG
CGGGACCTGGTGGGCATAGAGAACCTCATTGCTCCTGGCAGGGAGTTCATCCGTGAGGGC
TGCCTTCACAAGCTCACCAAGAAGGGCCTGCAGCAGAGGATGTTTTTTCTGTTCTCAGAT
ATGTTGCTGTACACAAGCAAAGGAGTTGCAGGGACCAGCCACTTCCGGATCCGGGGCCTC
CTTCCCCTCCAAGGCATGCTGGTGGAAGAAAGTGATAACGAGTGGTCTGTTCCACACTGT
TTCACCATCTACGCGGCTCAGAAAACAATCGTGGTGGCAGCCAGCACTCGGCTGGAGAAA
GAGAAGTGGATGCTGGACCTGAACTCCGCGATCCAAGCAGCCAAGAGTGGCGGTGACACG
GCCCCTGCACTGCCAGGCCGCACTGTGTGCACTCGTCCCCCCAGATCCCCCAACGAGGTA
TCTCTGGAGCAGGAGTCAGAAGATGATGCTCGGGGTGTCCGCAGCTCCCTGGAGGGGCAT
GGCCAGCACCGGGCCAACACCACAATGCACGTGTGCTGGTACCGGAACACCAGCGTGTCC
AGGGCAGACCACAGTGCAGCTGTCGAGAACCAGCTTTCAGGATATCTGCTAAGAAAGTTC
AAAAACAGTCATGGCTGGCAGAAGCTCTGGGTCGTCTTTACCAACTTCTGTTTGTTCTTC
TACAAAACTCATCAGGATGACTACCCACTGGCCAGCCTCCCGCTGCTGGGCTACAGCGTG
AGCATCCCCAGGGAGGCCGATGGCATACACAAAGACTATGTTTTCAAGCTCCAGTTCAAA
TCCCACGTCTACTTCTTCCGGGCTGAGAGCAAGTACACATTTGAAAGGTGGATGGAGGTG
ATCCAGGGGGCCAGCAGCTCAGCCGGGAGGGCCCCAAGCATCGTGCAGGATGGCCCCCAA
CCCTCCTCAGGGCTGGAGGGGATGGTCAGGGGGAAGGAGGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1054 |
| Molecular Weight
| 119887.5 |
| Theoretical pI
| 9.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FERM, RhoGEF and pleckstrin domain-containing protein 2
MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI
EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA
VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD
REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE
GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL
GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM
KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP
EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS
PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV
KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR
LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV
YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT
TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD
MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK
EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH
GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF
YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV
IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE
|
| External Links |
|---|
| GenBank ID Protein
| 7662310 |
| UniProtKB/Swiss-Prot ID
| O94887 |
| UniProtKB/Swiss-Prot Entry Name
| FARP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014808.2 |
| GeneCard ID
| FARP2 |
| GenAtlas ID
| FARP2 |
| HGNC ID
| HGNC:16460 |
| References |
|---|
| General References
| Not Available |