| Identification |
|---|
| HMDB Protein ID
| CDBP05062 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-specific guanine nucleotide-releasing factor RalGPS2 |
| Description
| Not Available |
| Synonyms
|
- Ral GEF with PH domain and SH3-binding motif 2
- RalA exchange factor RalGPS2
|
| Gene Name
| RALGPS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q25.2 |
| SNPs
| RALGPS2 |
| Gene Sequence
|
>1752 bp
ATGGACCTAATGAACGGGCAGGCAAGCAGTGTCAATATTGCAGCTACTGCTTCTGAGAAA
AGTAGCAGCTCTGAATCCTTAAGTGACAAAGGCTCTGAATTGAAGAAAAGCTTTGATGCT
GTGGTATTCGATGTTCTTAAGGTTACACCAGAAGAATATGCGGGTCAGATAACATTAATG
GATGTTCCAGTATTTAAAGCTATTCAACCAGATGAGCTTTCAAGTTGTGGATGGAATAAA
AAAGAAAAATATAGTTCTGCACCAAATGCAGTTGCCTTCACAAGAAGATTCAATCATGTA
AGCTTTTGGGTTGTTAGAGAGATTCTTCATGCTCAAACATTAAAAATTAGAGCAGAAGTT
TTGAGCCACTATATTAAAACTGCTAAGAAACTGTATGAGCTGAATAACCTTCATGCACTT
ATGGCAGTGGTTTCTGGCCTACAGAGTGCCCCAATTTTCAGGTTGACTAAAACATGGGCG
TTATTAAGTCGAAAAGACAAAACTACCTTTGAAAAATTAGAATATGTAATGAGTAAAGAA
GATAACTACAAAAGACTCAGAGACTATATAAGTAGCTTAAAGATGACACCTTGCATTCCC
TATTTAGGTATCTATTTGTCAGATTTAACATACATCGATTCAGCATACCCATCAACTGGC
AGCATTCTAGAAAATGAGCAAAGATCAAATTTAATGAATAATATCCTTCGAATAATTTCT
GATTTACAGCAGTCTTGTGAATATGATATTCCCATGTTGCCTCATGTCCAAAAATATCTC
AACTCTGTTCAGTATATAGAAGAACTACAAAAATTTGTGGAAGACGATAATTACAAGCTT
TCATTAAAGATAGAACCAGGGACAAGCACCCCACGTTCTGCTGCTTCCAGAGAAGATTTA
GTAGGTCCTGAAGTAGGAGCGTCTCCACAGAGTGGACGAAAAAGTGTGGCAGCTGAAGGA
GCCTTGCTCCCACAGACACCGCCATCCCCTCGGAATCTGATTCCACATGGACATAGGAAG
TGCCATAGTTTGGGTTATAATTTCATTCATAAAATGAACACAGCAGAATTTAAGAGTGCA
ACGTTTCCAAATGCAGGACCAAGACATCTGTTAGATGATAGCGTCATGGAGCCCCATGCG
CCATCTCGAGGCCAAGCTGAAAGTTCTACTCTTTCTAGTGGAATATCAATAGGTAGCAGC
GATGGTTCTGAACTAAGTGAAGAGACCTCATGGCCTGCTTTTGAAAGGAACAGATTATAC
CATTCTCTCGGCCCGGTGACAAGAGTGGCACGAAATGGCTATCGAAGTCACATGAAGGCC
AGCAGTTCTGCAGAATCAGAAGATTTGGCAGTACATTTATATCCAGGAGCTGTTACTATT
CAAGGTGTTCTCAGGAGAAAAACTTTGTTAAAAGAAGGCAAAAAGCCTACAGTAGCATCT
TGGACAAAATATTGGGCAGCTTTGTGTGGGACACAGCTTTTTTACTATGCTGCCAAATCT
CTAAAGGCTACCGAAAGAAAACATTTCAAATCAACATCCAATAAGAACGTATCTGTGATA
GGATGGATGGTGATGATGGCTGATGACCCTGAACATCCTGATCTCTTCCTGCTGACTGAC
TCTGAGAAAGGAAATTCGTACAAGTTTCAAGCTGGCAATAGAATGAATGCAATGTTATGG
TTTAAGCATTTGAGTGCAGCCTGCCAAAGTAACAAACAACAGGTTCCTACAAACTTGATG
ACTTTTGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 583 |
| Molecular Weight
| 65166.5 |
| Theoretical pI
| 9.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-specific guanine nucleotide-releasing factor RalGPS2
MDLMNGQASSVNIAATASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLM
DVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEV
LSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKE
DNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIIS
DLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDL
VGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSA
TFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLY
HSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVAS
WTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTD
SEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE
|
| External Links |
|---|
| GenBank ID Protein
| 32441283 |
| UniProtKB/Swiss-Prot ID
| Q86X27 |
| UniProtKB/Swiss-Prot Entry Name
| RGPS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_152663.3 |
| GeneCard ID
| RALGPS2 |
| GenAtlas ID
| RALGPS2 |
| HGNC ID
| HGNC:30279 |
| References |
|---|
| General References
| Not Available |