| Identification |
|---|
| HMDB Protein ID
| CDBP05061 |
| Secondary Accession Numbers
| Not Available |
| Name
| Switch-associated protein 70 |
| Description
| Not Available |
| Synonyms
|
- SWAP-70
|
| Gene Name
| SWAP70 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Nucleus
- Cytoplasm
- Cell projection
- lamellipodium
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15 |
| SNPs
| SWAP70 |
| Gene Sequence
|
>1758 bp
ATGGGGAGCTTGAAGGAGGAGCTGCTCAAAGCCATCTGGCACGCCTTCACCGCACTCGAC
CAGGACCACAGCGGCAAGGTCTCCAAGTCCCAGCTCAAGGTCCTTTCCCATAACCTGTGC
ACGGTGCTGAAGGTTCCTCATGACCCAGTTGCCCTTGAAGAGCACTTCAGGGATGATGAT
GAGGGTCCAGTGTCCAACCAGGGCTACATGCCTTATTTAAACAGGTTCATTTTGGAAAAG
GTCCAAGACAACTTTGACAAGATTGAATTCAATAGGATGTGTTGGACCCTCTGTGTCAAA
AAAAACCTCACAAAGAATCCCCTGCTCATTACAGAAGAAGATGCATTTAAAATATGGGTT
ATTTTCAACTTTTTATCTGAGGACAAGTATCCATTAATTATTGTGTCAGAAGAGATTGAA
TACCTGCTTAAGAAGCTTACAGAAGCTATGGGAGGAGGTTGGCAGCAAGAACAATTTGAA
CATTATAAAATCAACTTTGATGACAGTAAAAATGGCCTTTCTGCATGGGAACTTATTGAG
CTTATTGGAAATGGACAGTTTAGCAAAGGCATGGACCGGCAGACTGTGTCTATGGCAATT
AATGAAGTCTTTAATGAACTTATATTAGATGTGTTAAAGCAGGGTTACATGATGAAAAAG
GGCCACAGACGGAAAAACTGGACTGAAAGATGGTTTGTACTAAAACCCAACATAATTTCT
TACTATGTGAGTGAGGATCTGAAGGATAAGAAAGGAGACATTCTCTTGGATGAAAATTGC
TGTGTAGAGTCCTTGCCTGACAAAGATGGAAAGAAATGCCTTTTTCTCGTAAAATGTTTT
GATAAGACTTTTGAAATCAGTGCTTCAGATAAGAAGAAGAAACAGGAGTGGATTCAAGCC
ATTCATTCTACTATTCATCTGTTGAAGCTGGGCAGCCCTCCACCACACAAAGAAGCCCGC
CAGCGTCGGAAAGAACTCCGGAAGAAGCAGCTGGCTGAACAAGAGGAACTGGAGCGACAA
ATGAAGGAACTCCAGGCCGCCAACGAAAGCAAGCAGCAGGAGCTGGAGGCCGTGCGGAAG
AAACTGGAGGAAGCAGCATCTCGTGCAGCAGAAGAGGAAAAGAAACGCCTTCAGACTCAA
GTGGAACTTCAGGCCAGGTTCAGCACAGAGCTGGAAAGAGAGAAGCTTATCAGACAGCAG
ATGGAAGAACAGGTTGCTCAAAAGTCCTCTGAACTGGAACAGTATTTACAGCGAGTACGG
GAGCTGGAAGACATGTACCTAAAGCTGCAGGAGGCTCTTGAAGATGAGAGACAGGCCCGG
CAAGATGAAGAGACAGTGCGGAAGCTTCAGGCCAGGTTGTTGGAGGAAGAGTCTTCCAAG
AGGGCTGAACTAGAAAAGTGGCACTTGGAGCAGCAGCAGGCCATTCAGACAACCGAGGCG
GAGAAGCAGGAGTTGGAGAATCAGCGTGTCCTGAAGGAACAGGCCCTGCAGGAGGCCATG
GAGCAGCTGGAGCAGCTTGAGTTAGAACGGAAGCAAGCACTTGAGCAGTACGAGGAAGTT
AAAAAGAAGCTGGAGATGGCAACTAATAAGACCAAGAGCTGGAAGGACAAAGTGGCCCAT
CATGAAGGATTAATTCGACTGATAGAACCAGGTTCAAAGAACCCTCACCTGATCACTAAC
TGGGGACCTGCAGCTTTCACTGAGGCAGAACTTGAAGAGAGAGAGAAGAACTGGAAAGAG
AAAAAGACCACGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 585 |
| Molecular Weight
| 68997.2 |
| Theoretical pI
| 5.65 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Switch-associated protein 70
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDD
EGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWV
IFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIE
LIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIIS
YYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQA
IHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRK
KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR
ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA
EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH
HEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
|
| External Links |
|---|
| GenBank ID Protein
| 93102364 |
| UniProtKB/Swiss-Prot ID
| Q9UH65 |
| UniProtKB/Swiss-Prot Entry Name
| SWP70_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015055.2 |
| GeneCard ID
| SWAP70 |
| GenAtlas ID
| SWAP70 |
| HGNC ID
| HGNC:17070 |
| References |
|---|
| General References
| Not Available |