| Identification |
|---|
| HMDB Protein ID
| CDBP05060 |
| Secondary Accession Numbers
| Not Available |
| Name
| ALS2 C-terminal-like protein |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| ALS2CL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.31 |
| SNPs
| ALS2CL |
| Gene Sequence
|
>2862 bp
ATGTGCAACCCTGAGGAGGCAGCTCTGCTGCGGCTGGAGGAGGTCTTCTCAGCCACCCTC
GCCCATGTCAACAGCCTTGTCCTCCAGCCCCTGCTCCCAGCCGCCCCAGATCCCTCGGAT
CCCTGGGGCAGAGAGTGCCTGCGGCTCTTGCAACAGCTGCACAAGAGCTCCCAGCAACTC
TGGGAGGTGACGGAGGAAAGCCTGCACTCACTGCAGGAGAGGCTGCGTTACCCGGACTCC
ACCGGTCTGGAGTCCCTGCTGCTGCTGCGAGGTGCTGACCGTGTACTGCAGGCCCACATA
GAGTACATTGAGTCCTACACAAGCTGCATGGTGGTGCAGGCCTTCCAGAAGGCAGCAAAG
AGGAGAAGCGAGTACTGGCGGGGCCAGCGGAAGGCGCTGCGGCAGCTGCTTTCAGGTGTG
AGCTCAGAGGGCTCGGTGGGCGCATCGCTGGGCCAGGCCCTCCACCAGCCACTCGCCCAT
CACGTGCAACAGTACGTGCTCCTCCTGCTGAGCCTCGGGGACACCATTGGGGAGCATCAC
CCAACCCGGGAGCTGGTGGTGAACGCAGTCACCCTCTTTGGGAACCTGCAGTCCTTCATG
AAGCAGGAGTTGGACCAGGCTGTGGCCACACAGGCTCTCTGGCACACCCTGAGAGGCCGG
CTGAGGGATGTGCTCTGCACCCCTGCTCACAGACTCCTTCAGGACAGCCAGGACGTACCC
GTGACGGTCGCACCGTTGCGGGCTGAGCGTGTGCTGCTCTTTGATGATGCCCTCGTCCTG
CTGCAGGGCCACAATGTCCACACCTTTGATCTGAAGCTGGTGTGGGTGGATCCTGGGCAG
GACGGGTGCACGTTTCACCTCCTCACGCCCGAAGAAGAGTTCTCCTTTTGTGCCAAGGAC
TCCCAGGGCCAGGCAGTCTGGCAGTGGAAGGTGACCTGGGCTGTTCACCAGGCCCTGCAT
GGGAAGAAGGACTTCCCCGTGCTGGGGGCTGGCCTGGAGCCCTCCCAGCCTCCCGACTGC
CGCTGCGCAGAATATACCTTCCAGGCAGAGGGCCGGCTCTGCCAGGCCACCTACGAGGGC
GAGTGGTGCAGGGGCCGGCCCCACGGCAAGGGAACCCTGAAATGGCCGGATGGGCGGAAT
CATGTGGGGAATTTCTGCCAGGGCCTGGAGCATGGCTTCGGCATCCGCCTGCTGCCCCAG
GCCTCTGAGGACAAGTTCGACTGTTACAAGTGTCACTGGCGAGAAGGCAGCATGTGTGGC
TACGGCATCTGTGAGTACAGCACCGACGAGGTGTACAAGGGCTACTTCCAGGAGGGCCTG
CGGCACGGATTTGGGGTCCTTGAGAGTGGTCCGCAGGCCCCCCAGCCCTTCAGGTACACG
GGCCACTGGGAGAGGGGCCAGAGGAGCGGCTATGGCATTGAGGAGGATGGTGACAGAGGT
GAGCGCTACATTGGCATGTGGCAGGCTGGTCAGCGCCACGGCCCAGGGGTCATGGTCACC
CAGGCAGGTGTCTGCTACCAGGGCACCTTCCAGGCGGACAAGACGGTGGGCCCGGGCATC
CTCCTCTCTGAAGACGACTCCCTGTATGAGGGCACCTTCACCAGGGACCTGACCCTCATG
GGGAAGGGCAAGGTCACCTTCCCCAATGGCTTCACCCTGGAGGGCTCGTTCGGCAGTGGG
GCAGGGAGAGGACTGCACACACAGGGTGTGCTGGACACGGCTGCCCTCCCACCAGACCCG
AGCAGTACCTGCAAGAGGCAGCTGGGCGTGGGTGCCTTCCCCGTGGAAAGCCGCTGGCAG
GGAGTCTACAGCCCCTTCCGGGACTTTGTGTGTGCTGGCTGCCCCAGGGACCTGCAGGAG
GCCCTGCTGGGCTTCGACGTGCAGAGCTCCAGGGAGCTGCGTAGGTCTCAGGATTACCTG
TCCTGCGAGAGGACCCACCCTGAGGACAGTGTGGGCAGTATGGAAGACATCCTGGAGGAG
CTGCTGCAGCACCGGGAGCCCAAGGCCCTGCAGCTGTACCTCAGGAAGGCTCTGAGCAAC
TCACTGCACCCCCTGGGAAAGCTGCTCCGGACACTGATGCTGACCTTCCAGGCTACCTAC
GCAGGTGTCGGGGCCAACAAGCACCTGCAGGAGCTGGCCCAGGAGGAGGTGAAGCAGCAT
GCCCAGGAACTCTGGGCTGCCTACAGGGGTCTGCTGCGAGTTGCCTTAGAGCGCAAGGGC
CAGGCCCTGGAGGAGGATGAAGACACAGAGACAAGGGACCTCCAGGTGCATGGATTGGTG
CTGCCCCTCATGCTGCCCAGCTTCTACTCAGAGCTCTTCACGCTCTACCTGCTGCTTCAT
GAGCGGGAGGACAGCTTCTACAGCCAGGGCATTGCCAACTTGAGCCTCTTTCCTGATACC
CAACTGCTCGAGTTCCTGGATGTGCAGAAGCACTTGTGGCCCCTCAAGGACCTCACGCTG
ACGAGCAATCAGAGGTACTCCCTGGTCAGGGACAAGTGTTTCCTGTCAGCCACCGAGTGC
CTGCAGAAGATCATGACCACGGTGGACCCACGGGAGAAGCTGGAGGTGCTGGAGAGGACA
TACGGGGAAATTGAGGGCACGGTGTCGAGGGTATTGGGCCGGGAGTACAAGCTGCCCATG
GACGACCTGCTGCCACTTCTCATCTACGTGGTGTCGCGCGCCCGAATTCAGCACCTGGGA
GCCGAGATCCACCTGATCCGTGACATGATGGACCCCAACCACACAGGAGGCCTGTATGAC
TTCCTGCTCACAGCCCTGGAGTCCTGTTACGAGCACATCCAGAAAGAAGACATGAGGCTG
CACCGCTTACCTGGCCACTGGCACTCCAGGGAGCTCTGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 953 |
| Molecular Weight
| 107747.5 |
| Theoretical pI
| 6.09 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ALS2 C-terminal-like protein
MCNPEEAALLRLEEVFSATLAHVNSLVLQPLLPAAPDPSDPWGRECLRLLQQLHKSSQQL
WEVTEESLHSLQERLRYPDSTGLESLLLLRGADRVLQAHIEYIESYTSCMVVQAFQKAAK
RRSEYWRGQRKALRQLLSGVSSEGSVGASLGQALHQPLAHHVQQYVLLLLSLGDTIGEHH
PTRELVVNAVTLFGNLQSFMKQELDQAVATQALWHTLRGRLRDVLCTPAHRLLQDSQDVP
VTVAPLRAERVLLFDDALVLLQGHNVHTFDLKLVWVDPGQDGCTFHLLTPEEEFSFCAKD
SQGQAVWQWKVTWAVHQALHGKKDFPVLGAGLEPSQPPDCRCAEYTFQAEGRLCQATYEG
EWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREGSMCG
YGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRSGYGIEEDGDRG
ERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLM
GKGKVTFPNGFTLEGSFGSGAGRGLHTQGVLDTAALPPDPSSTCKRQLGVGAFPVESRWQ
GVYSPFRDFVCAGCPRDLQEALLGFDVQSSRELRRSQDYLSCERTHPEDSVGSMEDILEE
LLQHREPKALQLYLRKALSNSLHPLGKLLRTLMLTFQATYAGVGANKHLQELAQEEVKQH
AQELWAAYRGLLRVALERKGQALEEDEDTETRDLQVHGLVLPLMLPSFYSELFTLYLLLH
EREDSFYSQGIANLSLFPDTQLLEFLDVQKHLWPLKDLTLTSNQRYSLVRDKCFLSATEC
LQKIMTTVDPREKLEVLERTYGEIEGTVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLG
AEIHLIRDMMDPNHTGGLYDFLLTALESCYEHIQKEDMRLHRLPGHWHSRELW
|
| External Links |
|---|
| GenBank ID Protein
| 52693642 |
| UniProtKB/Swiss-Prot ID
| Q60I27 |
| UniProtKB/Swiss-Prot Entry Name
| AL2CL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB107015 |
| GeneCard ID
| ALS2CL |
| GenAtlas ID
| ALS2CL |
| HGNC ID
| HGNC:20605 |
| References |
|---|
| General References
| Not Available |