Identification
HMDB Protein ID CDBP05058
Secondary Accession Numbers Not Available
Name Ras-GEF domain-containing family member 1B
Description Not Available
Synonyms
  1. GPI gamma-4
Gene Name RASGEF1B
Protein Type Enzyme
Biological Properties
General Function Involved in guanyl-nucleotide exchange factor activity
Specific Function Guanine nucleotide exchange factor (GEF) for Ras family proteins (in vitro)
GO Classification
Component
cell part
intracellular
Function
guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction
small gtpase mediated signal transduction
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q21.21
SNPs RASGEF1B
Gene Sequence
>1422 bp
ATGCCTCAGACTCCTCCCTTTTCAGCAATGTTTGACAGCAGTGGTTACAATCGAAACCTC
TATCAGTCTGCAGAGGACAGCTGTGGAGGGTTGTATTACCATGACAACAACCTCCTCTCT
GGATCCCTGGAAGCACTCATCCAGCACTTAGTACCTAATGTGGATTACTATCCAGATAGA
ACATACATATTTACCTTCCTACTCAGTTCTCGGTTATTTATGCATCCGTATGAGCTAATG
GCCAAAGTTTGCCACTTATGTGTTGAGCACCAGAGACTAAGTGATCCTGATAGTGATAAG
AACCAGATGAGAAAAATTGCACCCAAAATCCTTCAACTCCTCACGGAATGGACGGAAACA
TTTCCCTATGATTTTCGGGATGAAAGAATGATGAGAAACTTAAAAGATCTGGCTCACCGA
ATAGCCAGTGGCGAAGAGCAGACATACAGAAAGAATGTCCAGCAAATGATGCAGTGTCTG
ATCCGCAAGCTTGCTGCGCTCAGCCAGTACGAAGAAGTCCTGGCAAAAATCAGCTCCACA
TCCACAGATCGGCTCACAGTTCTCAAGACCAAGCCACAGTCTATACAAAGGGATATCATT
ACTGTCTGCAACGACCCTTACACGTTGGCCCAGCAGCTGACTCATATAGAGCTGGAGAGG
CTCAATTATATTGGGCCAGAAGAATTTGTTCAGGCGTTCGTGCAGAAGGACCCTTTGGAT
AATGACAAGAGTTGCTACAGTGAACGGAAGAAAACACGAAACTTAGAAGCTTACGTGGAA
TGGTTTAATCGCCTCAGCTACTTGGTTGCTACAGAAATCTGTATGCCTGTTAAGAAAAAA
CACCGAGCAAGAATGATTGAGTATTTCATTGACGTAGCTCGGGAGTGTTTTAACATTGGC
AACTTCAACTCCTTGATGGCGATAATCTCTGGTATGAATATGAGCCCAGTCTCTCGACTA
AAAAAAACTTGGGCCAAAGTGAAGACTGCAAAATTTGACATTCTTGAGCATCAGATGGAC
CCTTCAAGCAATTTCTATAATTATCGAACAGCTCTTCGTGGGGCAGCACAAAGGTCTTTA
ACTGCTCATAGTAGTAGAGAAAAGATTGTGATACCATTCTTCAGTCTCTTAATCAAAGAT
ATTTATTTCCTCAATGAGGGTTGTGCCAACCGCCTTCCCAATGGCCATGTCAATTTTGAG
AAATTTTGGGAACTGGCCAAACAAGTGAGTGAATTTATGACATGGAAACAAGTGGAGTGT
CCATTTGAGAGGGACCGGAAGATCTTGCAGTATCTGCTCACAGTACCAGTCTTCAGTGAA
GATGCTCTCTACTTGGCTTCTTATGAGAGTGAAGGACCTGAAAATCATATAGAGAAAGAC
AGATGGAAGTCTTTAAGGTCGAGCCTCTTAGGCAGAGTTTAA
Protein Properties
Number of Residues 473
Molecular Weight 55359.0
Theoretical pI 8.09
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Ras-GEF domain-containing family member 1B
MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
GenBank ID Protein 22749129
UniProtKB/Swiss-Prot ID Q0VAM2
UniProtKB/Swiss-Prot Entry Name RGF1B_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_152545.1
GeneCard ID RASGEF1B
GenAtlas ID RASGEF1B
HGNC ID HGNC:24881
References
General References Not Available