Identification |
HMDB Protein ID
| CDBP05058 |
Secondary Accession Numbers
| Not Available |
Name
| Ras-GEF domain-containing family member 1B |
Description
| Not Available |
Synonyms
|
- GPI gamma-4
|
Gene Name
| RASGEF1B |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in guanyl-nucleotide exchange factor activity |
Specific Function
| Guanine nucleotide exchange factor (GEF) for Ras family proteins (in vitro) |
GO Classification
|
Component |
cell part |
intracellular |
Function |
guanyl-nucleotide exchange factor activity |
enzyme regulator activity |
nucleoside-triphosphatase regulator activity |
gtpase regulator activity |
Process |
biological regulation |
regulation of biological process |
regulation of cellular process |
signal transduction |
intracellular signal transduction |
small gtpase mediated signal transduction |
regulation of cell communication |
regulation of signal transduction |
regulation of small gtpase mediated signal transduction |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:4 |
Locus
| 4q21.21 |
SNPs
| RASGEF1B |
Gene Sequence
|
>1422 bp
ATGCCTCAGACTCCTCCCTTTTCAGCAATGTTTGACAGCAGTGGTTACAATCGAAACCTC
TATCAGTCTGCAGAGGACAGCTGTGGAGGGTTGTATTACCATGACAACAACCTCCTCTCT
GGATCCCTGGAAGCACTCATCCAGCACTTAGTACCTAATGTGGATTACTATCCAGATAGA
ACATACATATTTACCTTCCTACTCAGTTCTCGGTTATTTATGCATCCGTATGAGCTAATG
GCCAAAGTTTGCCACTTATGTGTTGAGCACCAGAGACTAAGTGATCCTGATAGTGATAAG
AACCAGATGAGAAAAATTGCACCCAAAATCCTTCAACTCCTCACGGAATGGACGGAAACA
TTTCCCTATGATTTTCGGGATGAAAGAATGATGAGAAACTTAAAAGATCTGGCTCACCGA
ATAGCCAGTGGCGAAGAGCAGACATACAGAAAGAATGTCCAGCAAATGATGCAGTGTCTG
ATCCGCAAGCTTGCTGCGCTCAGCCAGTACGAAGAAGTCCTGGCAAAAATCAGCTCCACA
TCCACAGATCGGCTCACAGTTCTCAAGACCAAGCCACAGTCTATACAAAGGGATATCATT
ACTGTCTGCAACGACCCTTACACGTTGGCCCAGCAGCTGACTCATATAGAGCTGGAGAGG
CTCAATTATATTGGGCCAGAAGAATTTGTTCAGGCGTTCGTGCAGAAGGACCCTTTGGAT
AATGACAAGAGTTGCTACAGTGAACGGAAGAAAACACGAAACTTAGAAGCTTACGTGGAA
TGGTTTAATCGCCTCAGCTACTTGGTTGCTACAGAAATCTGTATGCCTGTTAAGAAAAAA
CACCGAGCAAGAATGATTGAGTATTTCATTGACGTAGCTCGGGAGTGTTTTAACATTGGC
AACTTCAACTCCTTGATGGCGATAATCTCTGGTATGAATATGAGCCCAGTCTCTCGACTA
AAAAAAACTTGGGCCAAAGTGAAGACTGCAAAATTTGACATTCTTGAGCATCAGATGGAC
CCTTCAAGCAATTTCTATAATTATCGAACAGCTCTTCGTGGGGCAGCACAAAGGTCTTTA
ACTGCTCATAGTAGTAGAGAAAAGATTGTGATACCATTCTTCAGTCTCTTAATCAAAGAT
ATTTATTTCCTCAATGAGGGTTGTGCCAACCGCCTTCCCAATGGCCATGTCAATTTTGAG
AAATTTTGGGAACTGGCCAAACAAGTGAGTGAATTTATGACATGGAAACAAGTGGAGTGT
CCATTTGAGAGGGACCGGAAGATCTTGCAGTATCTGCTCACAGTACCAGTCTTCAGTGAA
GATGCTCTCTACTTGGCTTCTTATGAGAGTGAAGGACCTGAAAATCATATAGAGAAAGAC
AGATGGAAGTCTTTAAGGTCGAGCCTCTTAGGCAGAGTTTAA
|
Protein Properties |
Number of Residues
| 473 |
Molecular Weight
| 55359.0 |
Theoretical pI
| 8.09 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Ras-GEF domain-containing family member 1B
MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
|
External Links |
GenBank ID Protein
| 22749129 |
UniProtKB/Swiss-Prot ID
| Q0VAM2 |
UniProtKB/Swiss-Prot Entry Name
| RGF1B_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_152545.1 |
GeneCard ID
| RASGEF1B |
GenAtlas ID
| RASGEF1B |
HGNC ID
| HGNC:24881 |
References |
General References
| Not Available |