| Identification |
|---|
| HMDB Protein ID
| CDBP05054 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho guanine nucleotide exchange factor 37 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| ARHGEF37 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| May act as a guanine nucleotide exchange factor (GEF) |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| intracellular |
| Function |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| protein binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q32 |
| SNPs
| ARHGEF37 |
| Gene Sequence
|
>2028 bp
ATGGCCAAGCATGGAGCCGACGAGCCATCCTCCAGGTCAGGGAGTCCGGACAGGGAAGGT
AGGGCCTCTGAGGACAGATCGCTGCTTCATCAGAGGCTGGCTGTCCGGGAGCTCATCGAC
ACTGAGGTCTCCTACTTGCACATGCTCCAGCTCTGTGCCTCTGACATCAGGAGCCGCCTC
CAGCAGTTGCCGCAGGGAGATCTGGATGTCCTGTTCTCAAACATTGATGATATCATCAAA
GTGAACAGCAGATTCCTCCATGATCTGCAGGAGACAGCCTCCAAGGAAGAGGAACAAGTG
CAGCTAGTTGGTAACATATTTCTGGAATTCCAAGAGGAGTTGGAGCAAGTCTATAAGGTC
TACTGTGCCAGCTACGACCAGGCCTTGCTACTGGTGGACACGTACCGGAAGGAGCCGGAG
CTGCAGCGGCACATCCAGGGCATCGTTGAGGCGGTGGTGCCGCAAGCTGGATCTTCAGGC
CTCAGTTTCTTGCTGGTAATTCCTCTGCAGAGGATCACCAGGTACCCACTGCTGCTGCAG
AAAATCCTGGAGAACACAGTCCCTGATGCCAGTGCCTATCCTGTCCTTCAGAGGGCTGTC
TCTGCCCTCCAGGACGTGAACACCAATATCAATGAGTACAAGATGCGCAAGGAAGTGGCC
TCCAAGTACACCAAGGTAGAGCAGCTGACCCTCCGGGAGCGGCTGGCCCGCATCAACACA
CACACCCTCTCCAAGAAGACCACCCGGCTGAGCCAGCTGCTGAAGCAGGAGGCGGGGCTG
ATCCCCAGGACAGAAGACAAGGAATTTGATGATTTAGAAGAGAGGTTCCAGTGGGTGTCT
CTGTGTGTGACTGAGCTGAAGAACAACGTGGCTGCTTACCTGGACAATCTGCAGGCTTTC
CTCTACTTCAGGCCGCACGAATACAATCTGGACATCCCCGAGGGGCCTGCAGTGCAGTAT
TGCAATTTGGCAAGAGACCTTCACCTTGAGGCCTTCCTGAAATTTAAGCAACGGCTAGAA
GGCCTGGTGTGGCAGCCACTGTGCAGCCTGGCCAAAGCCCTGCTTGGCCCTCAGAACCTG
ATCAAGAAGCGTCTGGACAAGCTACTGGACTTTGAGCGGGTGGAAGAGAAGCTGCTGGAG
GTGGGCAGTGTGACCTACCAGGAGGAGGCCGCCCGGCACACATACCAGGCACTCAACTCG
CTGCTAGTGGCTGAGCTCCCACAGTTTAACCAGCTGGTCATGCAGTGGCTGGGCCAGATC
MTGTGCACATTCGTGACCCTCCAGAGGGACCTTGCAAAGCAAGTGCTGCAGAGGGCAGAG
GGAAGCATGGCCCAGCTGCCCCACCACCACGTCCCAGAGCCTGCCTTCAGGAAGCTGGTG
GAGGACGCACTGGGCCGGACGAGTAACCAGCTTCGCTCCTTTCAAGAGACCTTTGAGAAA
GTGCAGCCACCTCCCACCACACAACYGCTCCTTCCAGGGTCTGAACGCCAGGTGCAGGCT
CTCCTGAGCAGGTATGGCCCTGGGAAGCTGTACCAGGTGACAAGCAACATCAGTGGGACT
GGGACTCTGGACCTGACTCTGCCTCGGGGCCAAATCGTGGCCATCCTTCAAAACAAGGAC
ACCAAAGGCAACAGCGGCCGCTGGCTGGTGGACACCGGGGGACATCGTGGGTATGTGCCG
GCTGGGAAACTRCAGCTGTACCATGTGGTCCCCAGTGCAGAGGAGCTCAGAAGGCAGGCG
GGGCTGAACAAAGACCCCCGATGTCTAACACCGGAGCCCAGCCCAGCTCTAGTGCCCTCT
ATTCCCACCRTGAACCAGGTCATAGCCGCGTACCCTTTTGTGGCCAGAAGCAGCCATGAA
GTGAGCCTGCAGGCAGGCCAGCCTGTGACCATCCTGGAGGCCCAGGACAAGAAGGGGAAC
CCTGAGTGGAGCCTGGTGGAAGTGAATGGACAGAGGGGTTATGTGCCTTCTGGCTTCTTG
GCCAGGGCTCGGAGCCCAGTTCTGTGGGGCTGGAGTCTGCCCTCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 675 |
| Molecular Weight
| 76277.5 |
| Theoretical pI
| 6.92 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho guanine nucleotide exchange factor 37
MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRL
QQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKV
YCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQ
KILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINT
HTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAF
LYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNL
IKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQI
MCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEK
VQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKD
TKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPS
IPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL
ARARSPVLWGWSLPS
|
| External Links |
|---|
| GenBank ID Protein
| 121308635 |
| UniProtKB/Swiss-Prot ID
| A1IGU5 |
| UniProtKB/Swiss-Prot Entry Name
| ARH37_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB199796 |
| GeneCard ID
| ARHGEF37 |
| GenAtlas ID
| ARHGEF37 |
| HGNC ID
| HGNC:34430 |
| References |
|---|
| General References
| Not Available |