Showing Protein Pleckstrin homology domain-containing family G member 6 (CDBP05051)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP05051
Secondary Accession Numbers Not Available
Name Pleckstrin homology domain-containing family G member 6
Description Not Available
Synonyms
  1. MyoGEF
  2. Myosin-interacting guanine nucleotide exchange factor
  3. PH domain-containing family G member 6
Gene Name PLEKHG6
Protein Type Enzyme
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
  2. Cytoplasm
  3. Cytoplasm
  4. cytoskeleton
  5. cytoskeleton
  6. spindle
  7. spindle pole
  8. Cleavage furrow
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13.31
SNPs PLEKHG6
Gene Sequence 
>2373 bp
ATGAAGGCCTTTGGTCCTCCACATGAGGGCCCCCTCCAAGGACTCGTGGCCTCCCGCATT
GAGACTTATGGGGGCCGGCATCGAGCCTCTGCTCAGAGCACTGCTGGCAGACTCTATCCC
CGAGGATACCCTGTGCTGGATCCCAGTCGCCGACGCCTCCAGCAGTATGTCCCCTTTGCC
AGGGGTTCTGGCCAGGCCCGAGGCCTGTCACCCATGAGACTGCGAGATCCAGAGCCCGAG
AAGAGGCACGGGGGCCATGTGGGGGCTGGCCTGCTTCACTCCCCCAAACTCAAGGAACTC
ACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGGATGCCCCGG
CTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACC
ATCGAGAAGTCCTGGAGGGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGC
CACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTGAGAAAGCTC
AAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTG
ATGGAAGTGTCAGCTGAGACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGG
AGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCGGGCCAGCCT
CTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTAT
GTCCAGTACTGCCTCCGAGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACT
AACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCTGGGAGGCAG
ATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTC
CATGCTGTGCTCAAGAGGAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATT
GAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGCGAAGAGCAA
GAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGT
GATGAGGTGGAGAAGAACCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTG
GGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGAGTGAAGGAG
GGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACC
AAGCCCCAGCGCAAGGCGGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAG
CTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTCACTGAATTC
CAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGG
CTGGAGAAGACCCAGCAGGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTT
CAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCCCCCAGCACC
AGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAG
TTCTCGACCATTATCCCCCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTT
GTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACCCCCACGGGG
TCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACC
TTCTCCACCCTGGAACTCCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCT
CCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGCAGTCTTCCC
CAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTG
GTGGTGGAAACACTCCACAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCAT
GCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAAGAGGGGCCT
CTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGA
GAGATCCGGGAGGAGCTGGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGC
AGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCACATCATTCAG
CTGGACACCCCTCTGTCCGCATCAGAGGTATGA
Protein Properties
Number of Residues 790
Molecular Weight 88960.3
Theoretical pI 7.01
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Pleckstrin homology domain-containing family G member 6
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA
RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR
LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL
KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP
LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ
MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ
ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE
GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPDSFLLIHLTEF
QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST
RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG
SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP
QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP
LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ
LDTPLSASEV
GenBank ID Protein 222080068
UniProtKB/Swiss-Prot ID Q3KR16
UniProtKB/Swiss-Prot Entry Name PKHG6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001144856.1
GeneCard ID PLEKHG6
GenAtlas ID PLEKHG6
HGNC ID HGNC:25562
References
General References Not Available