| Identification |
|---|
| HMDB Protein ID
| CDBP05047 |
| Secondary Accession Numbers
| Not Available |
| Name
| PH and SEC7 domain-containing protein 4 |
| Description
| Not Available |
| Synonyms
|
- Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B
- Pleckstrin homology and SEC7 domain-containing protein 4
- Telomeric of interleukin-1 cluster protein
|
| Gene Name
| PSD4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ARF guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide exchange factor for ARF6-like protein. Involved in membrane recycling |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of arf protein signal transduction |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q13 |
| SNPs
| PSD4 |
| Gene Sequence
|
>3171 bp
ATGATGGGTGACTACAGACTCCCTGACCACCCCCAGCCCATGGAAATTCTCAACCTGTAC
TTGGGAGACAGCCTGGAGCCCCACCCAGGAGAGTGCCCAAGGGAAACGTGCAGCCATGAG
GATCCACCGGAGCCTTTCGAGGAGCAAACCTGGGCCACTGACCCTCCTGAACCTACCAGA
CAAAATGTTCCTCCCTGGGGCTCCGGTGTGGAGCTCACACACCTGGGGAGCTGGGTCCAT
CAGGACGGGCTGGAGCCTTGCCAGGAGCAAACCCGGGCCACTGACCCTCCTGAATCTACC
AGACAAGATGCTCCTCCCTGGGGCTCCGGTGTGGAGCTCACACACCTGGGGAGCCCCTCT
GCCCAGAGGGAGCACAGGCAGAACACAGCATCACCAGGGTCACCAGTGAACAGCCATCTA
CCGGGGAGCCCAAAGCAGAACCGGAGCACGTCCACACAGGTAGTGTTCTGGGCAGGCATC
CTGCAGGCCCAGATGTGTGTCCTAGACCTGGAGGAGGAGCTGGAGAAGACGGAAGGGCTC
AAGGCTGGGCTGAAATGCTGTCTCCCCACGCCCCCTGTGGACCTCCCCGGGGACACGGGC
CTGCACTCCAGCCCACCTGAGAATGAAGACTCAGGGGAAGACAGCAGTGAGCCTGAGGGA
GAGGGCCAGGCATGGCTGAGAGAGGGAACCCCAGACTCTTCCCCACAGTGGGGAGCTGAG
GAGGAGAGCATGTTCTTCAGCAACCCCCTCTTCCTGGCGAGTCCTTGCTCAGAGAACAGT
GCTTCTGGAGAGTGCTTTTCCTGGGGGGCTTCAGACTCCCATGCAGGTGTGAGGACTGGA
CCTGAGAGCCCAGCGACTCTGGAGCCTCCCCTCCCAGAAGACACAGTGCTGTGGGAGCTG
GAAAGTGAGCCAGATTTGGGGGACGGCGCTGCTATCAGTGGGCATTGTACCCCTCCATTC
CCTGTGCCCATCTATAAACCACACTCCATCTGCTGGGCCTCAGTGGCTGCCGCTGAGGGG
GCTCCTGCAGCACCTCCTGGTCACGGGGAGAGTGAGGGAGATAGGCTTGGTCCTGCTCCA
TCTGCAGCACCGTGTGTGGACGAAGCATTGACCTGGGAATCAGGATGTGTCGGATCTGAT
CTTGGCCCTGCTGCACATCCTGTGCAACCTTGGGCCTCTCTCAGCCCTGAGGGCTGGCAG
AGAGGAGGTCCTTTTTGGCCCCAGGTGACTCTTAACTCCCAGGACAGAGATGAGAGGGAG
GGTGGACACCCCCAGGAATCTCTTCCCTGCACCTTGGCCCCCTGCCCCTGGAGGAGCCCA
GCTTCTTCTCCAGAGCCTAGCAGCCCAGAATCTGAGAGCAGAGGCCCTGGTCCCAGGCCC
AGCCCTGCATCGTCCCAGGAGGGCAGCCCGCAGCTTCAACACCACAGCTCAGGCATTTTG
CCCAAGTGGACACTAGATGCTTCACAGTCTTCACTCTTGGAGACGGATGGGGAACAGCCA
AGTTCCTTGAAGAAAAAGGAGGCAGGGGAGGCCCCAAAACCAGGCGAGGAAGTAAAGAGT
GAAGGAACAGCCAGGCCTGCAGAGACTGGAGACGTCCAGCCTGACATTCACCTGACTTCT
GCAGAACATGAGAATCTGAGGACACCGATGAACTCTTCTTGGCTTCCTGGGAGCCCTATG
CCCCAAGCACAGTCCCCAGAGGAAGGCCAGAGACCACCAGCTGGAGACAAGCTAGCTAAT
GGCGTCAGGAACAACAAGGTAGCCTGGAACTTGGCCTCACGCCTCTATCGCCTGGAGGGC
TTCCGGAAGTCTGAAGTGGCTGCCTACCTGCAGAAGAACAATGACTTTAGCAGGGCTGTG
GCTGAGGAGTACCTGTCCTTCTTCCAGTTTGGAGGCCAGAGTCTGGACCGAGCCCTCCGG
AGCTTCCTCCAGGCCTTGGTGCTCAGTGGGGAGACTCAGGAACGGGAGCGAATCCTCTAC
CAGTTCTCCAGACGCTTCCACCATTGCAATCCGGGGATCTTCCCCTCAGTAGATTCTGTA
CACACCTTGACATGTGCAATCATGCTGCTTAACACGGACCTGCATGGACAGAACATTGGG
AAGAGCATGAGCTGCCAGGAATTCATAACCAACCTGAATGGGCTGAGGGATGGCGGGAAC
TTCCCCAAGGAGCTGCTGAAGGCCCTCTACTGGTCTATCCGCAGCGAGAAGCTCGAGTGG
GCCGTGGATGAAGAAGACACAGCCAGACCTGAGAAGGCCCAGCCGTCCCTGCCAGCTGGC
AAGATGAGCAAGCCCTTCCTTCAGCTGGCTCAGGATCCCACAGTGCCCACCTACAAGCAG
GGCATCCTGGCTCGGAAAATGCATCAAGATGCAGACGGCAAGAAGACGCCATGGGGCAAG
CGTGGCTGGAAGATGTTCCACACCTTACTGCGAGGGATGGTTCTCTACTTCCTGAAGCAG
GGAGAAGACCACTGTCTGGAGGGGGAGAGCTTGGTGGGGCAGATGGTGGATGAGCCCGTG
GGGGTGCACCACTCGCTGGCCACCCCCGCCACGCATTACACCAAGAAGCCGCACGTCTTC
CAGCTGCGCACGGCTGACTGGCGCCTCTACCTCTTCCAGGCACCCACTGCCAAGGAGATG
AGCTCCTGGATCGCGCGCATCAACTTGGCTGCGGCCACGCACTCCGCGCCGCCCTTCCCC
GCCGCTGTGGGCTCCCAGCGCAGATTCGTGCGGCCCATCCTGCCCGTGGGCCCCGCCCAG
AGCTCCCTGGAGGAGCAGCATCGATCCCACGAGAACTGCCTGGACGCTGCCGCGGACGAC
CTGCTGGATCTACAGAGGAACCTGCCGGAGCGGCGGGGCCGTGGCCGCGAGCTGGAGGAG
CACCGCCTGCGGAAGGAGTACCTGGAGTACGAGAAAACCCGCTACGAGACCTACGTGCAG
CTGCTGGTGGCCCGCCTGCACTGCCCCTCTGATGCTCTGGACCTGTGGGAGGAGCAGCTG
GGGAGGGAAGCTGGAGGCACTCGGGAGCCCAAGCTCAGCCTGAAGAAGTCCCACTCGAGC
CCGTCCCTGCACCAGGATGAGGCTCCCACCACGGCCAAGGTGAAGCGCAACATCTCAGAG
CGCAGAACCTACCGGAAGATCATCCCTAAGCGGAACCGCAATCAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1056 |
| Molecular Weight
| 116248.3 |
| Theoretical pI
| 5.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>PH and SEC7 domain-containing protein 4
MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTR
QNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPS
AQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGL
KAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAE
EESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWEL
ESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAP
SAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDERE
GGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGIL
PKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTS
AEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEG
FRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILY
QFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGN
FPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQ
GILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPV
GVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFP
AAVGSQRRFVRPILPVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEE
HRLRKEYLEYEKTRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSS
PSLHQDEAPTTAKVKRNISERRTYRKIIPKRNRNQL
|
| External Links |
|---|
| GenBank ID Protein
| 62630134 |
| UniProtKB/Swiss-Prot ID
| Q8NDX1 |
| UniProtKB/Swiss-Prot Entry Name
| PSD4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC016683 |
| GeneCard ID
| PSD4 |
| GenAtlas ID
| PSD4 |
| HGNC ID
| HGNC:19096 |
| References |
|---|
| General References
| Not Available |