| Identification |
|---|
| HMDB Protein ID
| CDBP05040 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-GEF domain-containing family member 1A |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| RASGEF1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide exchange factor (GEF) for KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q11.21 |
| SNPs
| RASGEF1A |
| Gene Sequence
|
>1446 bp
ATGCCCCAGACGTCCGTTGTCTTCTCCAGCATCCTTGGGCCCAGCTGTAGCGGACAGGTG
CAGCCTGGCATGGGGGAGCGTGGAGGCGGGGCCGGTGGCGGCTCCGGGGACCTCATCTTC
CAAGATGGACACCTCATCTCTGGGTCCCTGGAGGCCCTGATGGAGCACCTTGTTCCCACG
GTGGACTATTACCCCGATAGGACGTACATCTTCACCTTTCTCCTGAGCTCCCGGGTCTTT
ATGCCCCCTCATGACCTGCTGGCCCGCGTGGGGCAGATCTGCGTGGAGCAGAAGCAGCAG
CTGGAAGCCGGGCCTGAAAAGGCCAAGCTGAAGTCTTTCTCAGCCAAGATCGTGCAGCTC
CTGAAGGAGTGGACCGAGGCCTTCCCCTATGACTTCCAGGATGAGAAGGCCATGGCCGAG
CTGAAAGCCATCACACACCGTGTCACCCAGTGTGATGAGGAGAATGGCACAGTGAAGAAG
GCCATTGCCCAGATGACACAGAGCCTGTTGCTGTCCTTGGCTGCCCGGAGCCAGCTCCAG
GAACTGCGAGAGAAGCTCCGGCCACCGGCTGTAGACAAGGGGCCCATCCTCAAGACCAAG
CCACCAGCCGCCCAGAAGGACATCCTGGGCGTGTGCTGCGACCCCCTGGTGCTGGCCCAG
CAGCTGACTCACATTGAGCTGGACAGGGTCAGCAGCATTTACCCTGAGGACTTGATGCAG
ATCGTCAGCCACATGGACTCCTTGGACAACCACAGGTGCCGAGGGGACCTGACCAAGACC
TACAGCCTGGAGGCCTATGACAACTGGTTCAACTGCCTGAGCATGCTGGTGGCCACTGAG
GTGTGCCGGGTGGTGAAGAAGAAACACCGGACCCGCATGTTGGAGTTCTTCATTGATGTG
GCCCGGGAGTGCTTCAACATCGGGAACTTCAACTCCATGATGGCCATCATCTCTGGCATG
AACCTCAGTCCTGTGGCAAGGCTGAAGAAAACTTGGTCCAAGGTCAAGACAGCCAAGTTT
GATGTCTTGGAGCATCACATGGACCCGTCCAGCAACTTCTGCAACTACCGTACAGCCCTG
CAGGGGGCCACGCAGAGGTCCCAGATGGCCAACAGCAGCCGTGAAAAGATCGTCATCCCT
GTGTTCAACCTCTTCGTTAAGGACATCTACTTCCTGCACAAAATCCATACCAACCACCTG
CCCAACGGGCACATTAACTTTAAGAAATTCTGGGAGATCTCCAGACAGATCCATGAGTTC
ATGACATGGACACAGGTAGAGTGTCCTTTCGAGAAGGACAAGAAGATTCAGAGTTACCTG
CTCACGGCGCCCATCTACAGCGAGGAAGCTCTCTTCGTCGCCTCCTTTGAAAGTGAGGGT
CCCGAGAACCACATGGAAAAAGACAGCTGGAAGACCCTCAGGACCACCCTTCTGAACAGA
GCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 481 |
| Molecular Weight
| 54555.5 |
| Theoretical pI
| 7.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-GEF domain-containing family member 1A
MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT
VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL
LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ
ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ
IVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDV
ARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTAL
QGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEF
MTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNR
A
|
| External Links |
|---|
| GenBank ID Protein
| 117168263 |
| UniProtKB/Swiss-Prot ID
| Q8N9B8 |
| UniProtKB/Swiss-Prot Entry Name
| RGF1A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_145313.2 |
| GeneCard ID
| RASGEF1A |
| GenAtlas ID
| RASGEF1A |
| HGNC ID
| HGNC:24246 |
| References |
|---|
| General References
| Not Available |