Identification |
HMDB Protein ID
| CDBP04956 |
Secondary Accession Numbers
| Not Available |
Name
| Myosin-IXa |
Description
| Not Available |
Synonyms
|
- Unconventional myosin-9a
|
Gene Name
| MYO9A |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in motor activity |
Specific Function
| Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function |
GO Classification
|
Component |
protein complex |
intracellular |
myosin complex |
cell part |
macromolecular complex |
Function |
binding |
catalytic activity |
hydrolase activity |
motor activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
nucleoside-triphosphatase activity |
hydrolase activity, acting on acid anhydrides |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
pyrophosphatase activity |
Process |
regulation of biological process |
regulation of cellular process |
signal transduction |
intracellular signaling pathway |
signaling |
signaling pathway |
biological regulation |
|
Cellular Location
|
- Membrane
- Single-pass membrane protein (Potential)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 15q22-q23 |
SNPs
| MYO9A |
Gene Sequence
|
>7647 bp
ATGAATATAAATGATGGAGGAAGACGACGCTTTGAAGATAATGAACATACATTACGGATA
TATCCTGGGGCTATTTCAGAAGGGACAATCTACTGTCCGATTCCTGCCAGAAAAAACTCC
ACAGCTGCTGAGGTGATTGAGTCTCTTATAAACAAACTTCATCTTGACAAAACAAAATGT
TATGTTCTAGCAGAGGTAAAGGAATTTGGTGGAGAAGAATGGATTCTCAATCCAACAGAT
TGTCCAGTTCAGCGAATGATGCTGTGGCCCCGAATGGCTCTGGAAAATCGCTTAAGTGGA
GAGGACTACCGCTTCCTTCTGAGAGAGAAAAACCTTGATGGATCAATCCATTATGGTAGC
CTGCAGTCATGGCTACGGGTAACAGAAGAACGTCGCAGGATGATGGAACGGGGTTTTCTT
CCACAGCCTCAACAGAAAGACTTTGATGATTTATGTAGTTTACCTGATTTGAATGAGAAA
ACTCTCTTAGAAAACCTACGAAATCGCTTTAAGCATGAAAAAATTTATACCTATGTTGGC
AGTATTCTAATAGTTATTAACCCATTCAAGTTTCTTCCTATTTATAACCCCAAATATGTC
AAAATGTATGATAACCACCAACTGGGAAAACTTGAGCCCCACATTTATGCTGTGGCTGAT
GTAGCTTATCATGCCATGCTTCAGCGCAAAAAGAATCAGTGCATCGTGATTTCAGGAGAG
AGTGGTTCTGGGAAGACTCAAAGCACAAACTTTCTTATTCACCACCTTACTGCTCTCAGT
CAGAAAGGATTTGCCAGTGGAGTAGAACAGATTATTCTTGGAGCTGGACCAGTACTTGAG
GCCTTTGGAAATGCAAAGACAGCTCATAATAACAATTCAAGTCGTTTTGGGAAGTTTATT
CAAGTAAATTACCAGGAAACAGGCACTGTACTTGGTGCCTATGTTGAAAAATATCTACTG
GAGAAGTCCAGACTCGTTTATCAGGAGCATAATGAACGGAACTATCATGTATTCTATTAC
CTCCTGGCAGGAGCAAGTGAAGATGAGAGATCAGCATTCCATCTTAAGCAACCAGAGGAA
TATCATTATCTCAATCAGATAACAAAGAAACCCCTCAGACAGAGCTGGGATGATTATTGC
TATGACTCTGAGCCGGATTGCTTCACGGTGGAAGGAGAAGATTTGAGACATGACTTTGAG
CGCCTACAACTTGCCATGGAAATGGTAGGATTTCTTCCCAAGACACGAAGACAGATTTTC
TCTCTTCTCTCAGCCATACTACATTTGGGTAATATCTGTTACAAAAAGAAGACATACCGG
GATGACTCCATTGATATCTGTAATCCTGAAGTTCTGCCTATTGTCTCAGAATTATTAGAG
GTTAAAGAAGAGATGCTATTTGAAGCATTAGTTACAAGGAAGACGGTGACAGTGGGAGAA
AAGCTTATTTTGCCATACAAGTTGGCAGAGGCTGTGACAGTGAGGAACTCCATGGCTAAG
TCTCTGTATAGTGCCCTGTTTGACTGGATAGTTTTTCGAATTAATCATGCACTTCTGAAT
AGTAAAGATTTAGAGCATAATACCAAGACATTGTCTATTGGTGTTCTTGATATTTTTGGG
TTTGAAGATTATGAAAATAACAGCTTTGAACAGTTCTGTATTAATTTTGCTAATGAACGT
TTACAGCACTACTTTAATCAGCATATCTTTAAATTGGAACAAGAGGAATATAGAACTGAA
GGTATCAGCTGGCACAACATAGATTACATTGATAATACCTGCTGCATAAATCTTATTAGC
AAAAAACCAACAGGACTGCTTCATCTTTTGGATGAAGAAAGCAACTTTCCACAGGCTACA
AATCAAACATTGCTAGACAAGTTTAAGCATCAACATGAAGATAATTCTTACATCGAATTT
CCAGCCGTGATGGAGCCTGCTTTCATTATAAAACATTATGCTGGAAAAGTAAAATATGGG
GTAAAGGATTTCCGGGAAAAAAATACAGATCATATGCGCCCAGACATTGTAGCTCTTCTG
AGAAGCAGCAAGAATGCATTTATCTCTGGGATGATTGGAATTGATCCTGTAGCTGTTTTC
CGATGGGCAATTCTCCGAGCTTTTTTCAGAGCCATGGTTGCTTTCAGGGAAGCTGGGAAA
AGAAACATTCACAGAAAAACTGGACATGATGATACAGCGCCATGTGCAATTTTGAAAAGT
ATGGATAGTTTTAGCTTTCTCCAACACCCAGTCCACCAGAGGAGCTTAGAGATTCTGCAG
AGATGCAAGGAAGAGAAGTACAGTATAACCCGGAAAAATCCCAGAACACCTCTTTCTGAT
CTCCAGGGCATGAATGCTCTAAATGAAAAAAACCAACATGATACATTTGATATTGCCTGG
AATGGCAGAACTGGGATTCGCCAGAGCAGACTATCAAGTGGCACCTCCTTGCTTGATAAA
GATGGAATATTTGCTAATTCAACTAGCAGCAAACTCCTGGAGAGAGCCCATGGAATTCTC
ACGAGAAACAAAAATTTCAAATCCAAGCCTGCCCTTCCAAAGCACTTGCTAGAAGTAAAT
TCTTTAAAGCACCTGACAAGACTGACACTACAAGATCGCATTACCAAGTCTCTTCTTCAT
TTACACAAGAAGAAAAAACCTCCCAGCATCAGTGCCCAGTTTCAGGCATCATTAAGCAAG
CTAATGGAAACACTTGGTCAAGCAGAACCATATTTTGTAAAATGCATTCGCTCTAATGCT
GAAAAGCTGCCCTTAAGGTTCAGTGATGTCTTGGTACTTAGACAGCTTCGATACACCGGG
ATGCTGGAAACAGTTCGAATTCGCCAATCAGGATACAGCTCCAAATATTCTTTCCAGGAT
TTTGTGAGCCACTTCCATGTACTTCTTCCCCGAAATATTATTCCATCCAAATTTAACATT
CAGGATTTCTTCAGGAAAATAAATCTTAATCCAGATAATTATCAAGTTGGAAAAACCATG
GTCTTTCTAAAGGAGCAGGAACGACAGCACTTACAAGATCTGCTTCACCAAGAGGTGCTC
CGCAGAATCATATTGTTGCAGCGATGGTTCAGGGTCTTGCTGTGTAGGCAGCATTTCCTC
CATCTGAGACAAGCATCTGTTATTATCCAGAGATTCTGGAGGAATTACCTAAATCAGAAG
CAAGTCAGAGATGCAGCTGTGCAGAAGGATGCTTTTGTTATGGCTAGTGCAGCTGCTCTT
CTCCAAGCTTCCTGGCGTGCTCACTTAGAGAGGCAGCGGTACTTGGAGTTACGGGCTGCA
GCCATCGTTATCCAGCAGAAATGGAGAGATTACTATAGGCGCAGGCACATGGCTGCTATT
TGCATACAAGCAAGATGGAAAGCCTACAGGGAAAGTAAAAGGTACCAAGAACAAAGGAAA
AAAATTATCCTTTTGCAATCAACATGTAGAGGATTCAGAGCAAGACAAAGATTTAAAGCT
TTAAAAGAACAAAGGCTAAGAGAAACAAAGCCAGAAGTTGGATTGGTGAATATTAAGGGA
TATGGATCTCTGGAAATTCAGGGTTCAGACCCTTCAGGATGGGAGGATTGTTCTTTTGAC
AACAGAATAAAAGCCATAGAGGAATGTAAATCTGTAATAGAGAGTAATCGAATTAGCCGT
GAAAGTTCAGTGGACTGCTTGAAGGAGTCACCAAACAAGCAGCAGGAGAGAGCCCAAAGC
CAGAGTGGTGTGGACTTGCAGGAAGATGTGCTTGTAAGAGAGAGACCCAGATCCTTGGAG
GATCTCCATCAGAAAAAAGTAGGCCGGGCTAAGAGAGAAAGTAGGAGAATGAGAGAACTA
GAGCAAGCTATATTTAGCTTAGAATTGCTGAAAGTTCGTTCTCTTGGTGGTATTTCTCCT
TCAGAGGATCGCAGATGGTCTACAGAATTGGTGCCTGAAGGCCTTCAGTCTCCACGGGGT
ACACCTGATAGTGAGAGCTCTCAAGGAAGCTTGGAACTTCTGAGCTATGAGGAAAGCCAA
AAGAGCAAACTAGAGTCTGTCATTTCAGATGAAGGAGACTTGCAGTTTCCATCACCTAAG
ATATCCAGCAGTCCAAAATTTGATTCACGGGACAATGCCCTCAGTGCCTCAAATGAGACT
AGCAGTGCAGAGCATTTGAAGGATGGAACTATGAAGGAAATGGTGGTCTGCAGTTCTGAG
TCTATTACCTGTAAACCACAGCTGAAAGACTCCTTCATTTCAAATAGTCTACCTACTTTT
TTTTATATCCCCCAACAAGACCCACTGAAAACAAATTCCCAACTAGACACAAGTATCCAA
AGAAACAAACTATTGGAAAATGAAGACACAGCGGGGGAAGCTCTTACTTTGGATATCAAC
AGGGAAACTAGAAGGTATCACTGCTCAGGAAAAGATCAGATTGTTCCTTCTTTGAATACA
GAGTCTTCTAATCCTGTGCTTAAGAAGTTAGAAAAGCTAAACACTGAGAAGGAAGAAAGG
CAAAAACAGTTGCAGCAACAGAATGAAAAAGAGATGATGGAACAGATTCGCCAGCAAACA
GATATTTTAGAGAAGGAGCGCAAAGCCTTCAAGACAATTGAAAAGCCAAGAATTGGAGAG
TGTTTGGTGGCACCATCTTCCTATCAGTCAAAGCAAAGAGTAGAGAGGCCATCCTCTCTC
CTCAGCTTAAATACCTCAAATAAGGGAGAACTTAATGTACTGGGGTCCCTATCATTAAAA
GATGCAGCTCTTGCCCAAAAAGACAGTTCCTCTGCTCACTTACCCCCAAAGGACCGACCT
GTCACCGTGTTCTTTGAAAGAAAAGGAAGTCCATGCCAATCTAGTACTGTCAAGGAATTA
TCCAAGACAGACAGAATGGGCACCCAGCTGAATGTAGCCTGTAAACTCTCAAATAATCGC
ATTTCAAAAAGAGAACACTTTAGGCCAACTCAGTCTTACAGCCACAATTCTGATGACCTT
TCCAGAGAGGGAAATGCTAGGCCCATTTTCTTCACTCCAAAGGACAATATGAGTATTCCC
CTTGTCAGCAAAGAAGCCTTAAACAGTAAAAATCCTCAACTCCATAAAGAAGATGAACCA
GCATGGAAACCTGTGAAGTTAGCTGGGCCAGGCCAAAGAGAGACATCACAGCGATTTTCG
TCAGTTGATGAACAAGCAAAACTTCATAAGACTATGTCTCAAGGAGAGATTACCAAGTTG
GCAGTGAGACAGAAGGCTTCAGATTCAGATATAAGACCTCAGAGAGCTAAGATGAGATTC
TGGGCCAAAGGGAAACAAGGGGAGAAGAAGACTACCAGAGTGAAACCTACTACCCAGTCA
GAGGTTTCGCCACTCTTTGCAGGCACAGATGTGATTCCAGCTCATCAGTTTCCAGATGAA
TTAGCTGCATATCACCCAACACCTCCTTTGAGCCCAGAACTGCCCGGCAGTTGCCGGAAG
GAATTCAAAGAGAACAAAGAACCTTCTCCAAAGGCTAAGCGCAAGCGAAGTGTGAAGATT
AGCAACGTGGCTTTGGATTCTATGCATTGGCAAAATGACTCTGTCCAGATCATAGCAAGT
GTCAGTGATTTAAAAAGCATGGATGAATTTCTTCTGAAAAAGGTGAATGACCTAGATAAT
GAAGACAGCAAGAAGGATACACTAGTGGATGTTGTATTTAAAAAAGCCCTGAAGGAATTT
CGGCAGAATATCTTCAGCTTTTATTCATCTGCATTGGCGATGGATGATGGGAAAAGCATA
CGGTATAAAGACCTCTATGCACTATTTGAACAGATTCTGGAAAAGACGATGAGGCTTGAG
CAGCGTGATTCACTGGGTGAATCTCCAGTGAGAGTTTGGGTCAACACTTTTAAAGTGTTT
TTAGATGAATATATGAATGAATTCAAGACTTCAGATTGCACAGCCACAAAGGTGCCAAAA
ACAGAAAGAAAGAAAAGAAGGAAAAAGGAAACTGATTTGGTGGAAGAACACAATGGTCAC
ATCTTTAAAGCCACCCAATATAGCATCCCTACATACTGTGAATACTGTTCTTCTTTGATA
TGGATAATGGACCGAGCCTCTGTTTGCAAATTATGCAAGTATGCTTGCCATAAGAAGTGC
TGTCTGAAAACCACAGCCAAGTGCTCTAAAAAGTATGATCCAGAGCTGTCATCTCGACAA
TTTGGGGTTGAACTGTCCCGTTTGACCAGTGAAGACCGAACTGTTCCTTTAGTAGTGGAA
AAGCTCATAAACTACATTGAAATGCATGGACTGTATACAGAAGGTATTTATCGAAAGTCT
GGTTCGACTAATAAAATCAAGGAGCTTCGGCAGGGTCTAGATACAGATGCTGAGAGTGTA
AATCTAGATGACTATAACATACACGTCATTGCAAGTGTATTCAAACAATGGCTTCGAGAT
TTGCCCAATCCTCTCATGACCTTTGAACTCTATGAGGAATTTCTTCGAGCTATGGGCCTT
CAGGAGAGGAAGGAGACAATCCGTGGTGTATACTCTGTGATTGATCAACTCTCCCGAACT
CATCTCAATACACTGGAACGCCTCATCTTTCATCTAGTCAGGATTGCTCTGCAGGAAGAC
ACTAATCGAATGTCTGCTAATGCTTTGGCCATTGTGTTTGCGCCCTGCATTCTCCGCTGC
CCTGACACCACTGACCCACTACAAAGTGTACAGGACATCAGTAAGACTACCACTTGTGTG
GAACTGATTGTTGTGGAACAAATGAATAAATACAAGGCTCGTCTCAAAGATATCAGTAGC
TTGGAATTTGCTGAGAATAAGGCAAAGACCAGGTTGTCACTGATTCGTAGATCAATGGGA
AAGGGGCGTATTCGTCGAGGAAACTATCCAGGTCCATCGTCTCCTGTTGTAGTTCGGTTG
CCTTCTGTGTCTGATGTCTCAGAGGAGACCTTGACTAGTGAGGCAGCCATGGAGACTGAC
ATCACAGAACAGCAGCAAGCAGCTATGCAGCAGGAGGAGAGAGTACTGACTGAGCAGATT
GAGAACCTACAGAAGGAGAAGGAGGAGCTAACATTTGAGATGCTTGTACTGGAACCCCGT
GCCTCTGATGATGAAACCCTTGAGTCTGAGGCCTCCATTGGGACTGCTGATAGCTCAGAG
AATTTGAATATGGAGTCTGAATATGCTATCTCTGAGAAATCAGAAAGAAGCTTAGCCCTT
AGCTCCCTGAAGACAGCTGGCAAGTCTGAACCTTCCAGCAAGTTGCGAAAGCAACTTAAA
AAGCAGCAAGACTCTTTAGATGTCGTGGACTCTTCGGTCTCCTCTTTATGTCTGTCTAAC
ACGGCATCATCTCATGGGACCAGAAAACTATTTCAGATTTATTCCAAATCTCCATTCTAC
CGAGCTGCCTCAGGTAATGAGGCCCTGGGAATGGAAGGACCATTGGGCCAGACCAAATTC
CTGGAAGACAAGCCTCAGTTCATCAGCAGAGGAACCTTCAACCCGGAAAAGGGCAAACAA
AAATTAAAGAATGTGAAAAACTCACCTCAGAAAACCAAAGAGACCCCAGAGGGGACAGTC
ATGTCTGGCCGCAGAAAAACTGTGGACCCAGACTGCACCTCCAACCAACAGCTAGCACTC
TTTGGAAATAATGAATTTATGGTCTGA
|
Protein Properties |
Number of Residues
| 2548 |
Molecular Weight
| 292703.0 |
Theoretical pI
| 9.22 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Myosin-IXa
MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKC
YVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGS
LQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVG
SILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGE
SGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFI
QVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEE
YHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIF
SLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGE
KLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFG
FEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLIS
KKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYG
VKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGK
RNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSD
LQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGIL
TRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSK
LMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQD
FVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVL
RRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAAL
LQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRK
KIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFD
NRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLE
DLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRG
TPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNET
SSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQ
RNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEER
QKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSL
LSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKEL
SKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIP
LVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKL
AVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDE
LAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIAS
VSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSI
RYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPK
TERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKC
CLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKS
GSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGL
QERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRC
PDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMG
KGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQI
ENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLAL
SSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFY
RAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTV
MSGRRKTVDPDCTSNQQLALFGNNEFMV
|
External Links |
GenBank ID Protein
| 156119615 |
UniProtKB/Swiss-Prot ID
| B2RTY4 |
UniProtKB/Swiss-Prot Entry Name
| MYO9A_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_006901.2 |
GeneCard ID
| MYO9A |
GenAtlas ID
| MYO9A |
HGNC ID
| HGNC:7608 |
References |
General References
| Not Available |