Identification
HMDB Protein ID CDBP04956
Secondary Accession Numbers Not Available
Name Myosin-IXa
Description Not Available
Synonyms
  1. Unconventional myosin-9a
Gene Name MYO9A
Protein Type Enzyme
Biological Properties
General Function Involved in motor activity
Specific Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function
GO Classification
Component
protein complex
intracellular
myosin complex
cell part
macromolecular complex
Function
binding
catalytic activity
hydrolase activity
motor activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Process
regulation of biological process
regulation of cellular process
signal transduction
intracellular signaling pathway
signaling
signaling pathway
biological regulation
Cellular Location
  1. Membrane
  2. Single-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 15q22-q23
SNPs MYO9A
Gene Sequence
>7647 bp
ATGAATATAAATGATGGAGGAAGACGACGCTTTGAAGATAATGAACATACATTACGGATA
TATCCTGGGGCTATTTCAGAAGGGACAATCTACTGTCCGATTCCTGCCAGAAAAAACTCC
ACAGCTGCTGAGGTGATTGAGTCTCTTATAAACAAACTTCATCTTGACAAAACAAAATGT
TATGTTCTAGCAGAGGTAAAGGAATTTGGTGGAGAAGAATGGATTCTCAATCCAACAGAT
TGTCCAGTTCAGCGAATGATGCTGTGGCCCCGAATGGCTCTGGAAAATCGCTTAAGTGGA
GAGGACTACCGCTTCCTTCTGAGAGAGAAAAACCTTGATGGATCAATCCATTATGGTAGC
CTGCAGTCATGGCTACGGGTAACAGAAGAACGTCGCAGGATGATGGAACGGGGTTTTCTT
CCACAGCCTCAACAGAAAGACTTTGATGATTTATGTAGTTTACCTGATTTGAATGAGAAA
ACTCTCTTAGAAAACCTACGAAATCGCTTTAAGCATGAAAAAATTTATACCTATGTTGGC
AGTATTCTAATAGTTATTAACCCATTCAAGTTTCTTCCTATTTATAACCCCAAATATGTC
AAAATGTATGATAACCACCAACTGGGAAAACTTGAGCCCCACATTTATGCTGTGGCTGAT
GTAGCTTATCATGCCATGCTTCAGCGCAAAAAGAATCAGTGCATCGTGATTTCAGGAGAG
AGTGGTTCTGGGAAGACTCAAAGCACAAACTTTCTTATTCACCACCTTACTGCTCTCAGT
CAGAAAGGATTTGCCAGTGGAGTAGAACAGATTATTCTTGGAGCTGGACCAGTACTTGAG
GCCTTTGGAAATGCAAAGACAGCTCATAATAACAATTCAAGTCGTTTTGGGAAGTTTATT
CAAGTAAATTACCAGGAAACAGGCACTGTACTTGGTGCCTATGTTGAAAAATATCTACTG
GAGAAGTCCAGACTCGTTTATCAGGAGCATAATGAACGGAACTATCATGTATTCTATTAC
CTCCTGGCAGGAGCAAGTGAAGATGAGAGATCAGCATTCCATCTTAAGCAACCAGAGGAA
TATCATTATCTCAATCAGATAACAAAGAAACCCCTCAGACAGAGCTGGGATGATTATTGC
TATGACTCTGAGCCGGATTGCTTCACGGTGGAAGGAGAAGATTTGAGACATGACTTTGAG
CGCCTACAACTTGCCATGGAAATGGTAGGATTTCTTCCCAAGACACGAAGACAGATTTTC
TCTCTTCTCTCAGCCATACTACATTTGGGTAATATCTGTTACAAAAAGAAGACATACCGG
GATGACTCCATTGATATCTGTAATCCTGAAGTTCTGCCTATTGTCTCAGAATTATTAGAG
GTTAAAGAAGAGATGCTATTTGAAGCATTAGTTACAAGGAAGACGGTGACAGTGGGAGAA
AAGCTTATTTTGCCATACAAGTTGGCAGAGGCTGTGACAGTGAGGAACTCCATGGCTAAG
TCTCTGTATAGTGCCCTGTTTGACTGGATAGTTTTTCGAATTAATCATGCACTTCTGAAT
AGTAAAGATTTAGAGCATAATACCAAGACATTGTCTATTGGTGTTCTTGATATTTTTGGG
TTTGAAGATTATGAAAATAACAGCTTTGAACAGTTCTGTATTAATTTTGCTAATGAACGT
TTACAGCACTACTTTAATCAGCATATCTTTAAATTGGAACAAGAGGAATATAGAACTGAA
GGTATCAGCTGGCACAACATAGATTACATTGATAATACCTGCTGCATAAATCTTATTAGC
AAAAAACCAACAGGACTGCTTCATCTTTTGGATGAAGAAAGCAACTTTCCACAGGCTACA
AATCAAACATTGCTAGACAAGTTTAAGCATCAACATGAAGATAATTCTTACATCGAATTT
CCAGCCGTGATGGAGCCTGCTTTCATTATAAAACATTATGCTGGAAAAGTAAAATATGGG
GTAAAGGATTTCCGGGAAAAAAATACAGATCATATGCGCCCAGACATTGTAGCTCTTCTG
AGAAGCAGCAAGAATGCATTTATCTCTGGGATGATTGGAATTGATCCTGTAGCTGTTTTC
CGATGGGCAATTCTCCGAGCTTTTTTCAGAGCCATGGTTGCTTTCAGGGAAGCTGGGAAA
AGAAACATTCACAGAAAAACTGGACATGATGATACAGCGCCATGTGCAATTTTGAAAAGT
ATGGATAGTTTTAGCTTTCTCCAACACCCAGTCCACCAGAGGAGCTTAGAGATTCTGCAG
AGATGCAAGGAAGAGAAGTACAGTATAACCCGGAAAAATCCCAGAACACCTCTTTCTGAT
CTCCAGGGCATGAATGCTCTAAATGAAAAAAACCAACATGATACATTTGATATTGCCTGG
AATGGCAGAACTGGGATTCGCCAGAGCAGACTATCAAGTGGCACCTCCTTGCTTGATAAA
GATGGAATATTTGCTAATTCAACTAGCAGCAAACTCCTGGAGAGAGCCCATGGAATTCTC
ACGAGAAACAAAAATTTCAAATCCAAGCCTGCCCTTCCAAAGCACTTGCTAGAAGTAAAT
TCTTTAAAGCACCTGACAAGACTGACACTACAAGATCGCATTACCAAGTCTCTTCTTCAT
TTACACAAGAAGAAAAAACCTCCCAGCATCAGTGCCCAGTTTCAGGCATCATTAAGCAAG
CTAATGGAAACACTTGGTCAAGCAGAACCATATTTTGTAAAATGCATTCGCTCTAATGCT
GAAAAGCTGCCCTTAAGGTTCAGTGATGTCTTGGTACTTAGACAGCTTCGATACACCGGG
ATGCTGGAAACAGTTCGAATTCGCCAATCAGGATACAGCTCCAAATATTCTTTCCAGGAT
TTTGTGAGCCACTTCCATGTACTTCTTCCCCGAAATATTATTCCATCCAAATTTAACATT
CAGGATTTCTTCAGGAAAATAAATCTTAATCCAGATAATTATCAAGTTGGAAAAACCATG
GTCTTTCTAAAGGAGCAGGAACGACAGCACTTACAAGATCTGCTTCACCAAGAGGTGCTC
CGCAGAATCATATTGTTGCAGCGATGGTTCAGGGTCTTGCTGTGTAGGCAGCATTTCCTC
CATCTGAGACAAGCATCTGTTATTATCCAGAGATTCTGGAGGAATTACCTAAATCAGAAG
CAAGTCAGAGATGCAGCTGTGCAGAAGGATGCTTTTGTTATGGCTAGTGCAGCTGCTCTT
CTCCAAGCTTCCTGGCGTGCTCACTTAGAGAGGCAGCGGTACTTGGAGTTACGGGCTGCA
GCCATCGTTATCCAGCAGAAATGGAGAGATTACTATAGGCGCAGGCACATGGCTGCTATT
TGCATACAAGCAAGATGGAAAGCCTACAGGGAAAGTAAAAGGTACCAAGAACAAAGGAAA
AAAATTATCCTTTTGCAATCAACATGTAGAGGATTCAGAGCAAGACAAAGATTTAAAGCT
TTAAAAGAACAAAGGCTAAGAGAAACAAAGCCAGAAGTTGGATTGGTGAATATTAAGGGA
TATGGATCTCTGGAAATTCAGGGTTCAGACCCTTCAGGATGGGAGGATTGTTCTTTTGAC
AACAGAATAAAAGCCATAGAGGAATGTAAATCTGTAATAGAGAGTAATCGAATTAGCCGT
GAAAGTTCAGTGGACTGCTTGAAGGAGTCACCAAACAAGCAGCAGGAGAGAGCCCAAAGC
CAGAGTGGTGTGGACTTGCAGGAAGATGTGCTTGTAAGAGAGAGACCCAGATCCTTGGAG
GATCTCCATCAGAAAAAAGTAGGCCGGGCTAAGAGAGAAAGTAGGAGAATGAGAGAACTA
GAGCAAGCTATATTTAGCTTAGAATTGCTGAAAGTTCGTTCTCTTGGTGGTATTTCTCCT
TCAGAGGATCGCAGATGGTCTACAGAATTGGTGCCTGAAGGCCTTCAGTCTCCACGGGGT
ACACCTGATAGTGAGAGCTCTCAAGGAAGCTTGGAACTTCTGAGCTATGAGGAAAGCCAA
AAGAGCAAACTAGAGTCTGTCATTTCAGATGAAGGAGACTTGCAGTTTCCATCACCTAAG
ATATCCAGCAGTCCAAAATTTGATTCACGGGACAATGCCCTCAGTGCCTCAAATGAGACT
AGCAGTGCAGAGCATTTGAAGGATGGAACTATGAAGGAAATGGTGGTCTGCAGTTCTGAG
TCTATTACCTGTAAACCACAGCTGAAAGACTCCTTCATTTCAAATAGTCTACCTACTTTT
TTTTATATCCCCCAACAAGACCCACTGAAAACAAATTCCCAACTAGACACAAGTATCCAA
AGAAACAAACTATTGGAAAATGAAGACACAGCGGGGGAAGCTCTTACTTTGGATATCAAC
AGGGAAACTAGAAGGTATCACTGCTCAGGAAAAGATCAGATTGTTCCTTCTTTGAATACA
GAGTCTTCTAATCCTGTGCTTAAGAAGTTAGAAAAGCTAAACACTGAGAAGGAAGAAAGG
CAAAAACAGTTGCAGCAACAGAATGAAAAAGAGATGATGGAACAGATTCGCCAGCAAACA
GATATTTTAGAGAAGGAGCGCAAAGCCTTCAAGACAATTGAAAAGCCAAGAATTGGAGAG
TGTTTGGTGGCACCATCTTCCTATCAGTCAAAGCAAAGAGTAGAGAGGCCATCCTCTCTC
CTCAGCTTAAATACCTCAAATAAGGGAGAACTTAATGTACTGGGGTCCCTATCATTAAAA
GATGCAGCTCTTGCCCAAAAAGACAGTTCCTCTGCTCACTTACCCCCAAAGGACCGACCT
GTCACCGTGTTCTTTGAAAGAAAAGGAAGTCCATGCCAATCTAGTACTGTCAAGGAATTA
TCCAAGACAGACAGAATGGGCACCCAGCTGAATGTAGCCTGTAAACTCTCAAATAATCGC
ATTTCAAAAAGAGAACACTTTAGGCCAACTCAGTCTTACAGCCACAATTCTGATGACCTT
TCCAGAGAGGGAAATGCTAGGCCCATTTTCTTCACTCCAAAGGACAATATGAGTATTCCC
CTTGTCAGCAAAGAAGCCTTAAACAGTAAAAATCCTCAACTCCATAAAGAAGATGAACCA
GCATGGAAACCTGTGAAGTTAGCTGGGCCAGGCCAAAGAGAGACATCACAGCGATTTTCG
TCAGTTGATGAACAAGCAAAACTTCATAAGACTATGTCTCAAGGAGAGATTACCAAGTTG
GCAGTGAGACAGAAGGCTTCAGATTCAGATATAAGACCTCAGAGAGCTAAGATGAGATTC
TGGGCCAAAGGGAAACAAGGGGAGAAGAAGACTACCAGAGTGAAACCTACTACCCAGTCA
GAGGTTTCGCCACTCTTTGCAGGCACAGATGTGATTCCAGCTCATCAGTTTCCAGATGAA
TTAGCTGCATATCACCCAACACCTCCTTTGAGCCCAGAACTGCCCGGCAGTTGCCGGAAG
GAATTCAAAGAGAACAAAGAACCTTCTCCAAAGGCTAAGCGCAAGCGAAGTGTGAAGATT
AGCAACGTGGCTTTGGATTCTATGCATTGGCAAAATGACTCTGTCCAGATCATAGCAAGT
GTCAGTGATTTAAAAAGCATGGATGAATTTCTTCTGAAAAAGGTGAATGACCTAGATAAT
GAAGACAGCAAGAAGGATACACTAGTGGATGTTGTATTTAAAAAAGCCCTGAAGGAATTT
CGGCAGAATATCTTCAGCTTTTATTCATCTGCATTGGCGATGGATGATGGGAAAAGCATA
CGGTATAAAGACCTCTATGCACTATTTGAACAGATTCTGGAAAAGACGATGAGGCTTGAG
CAGCGTGATTCACTGGGTGAATCTCCAGTGAGAGTTTGGGTCAACACTTTTAAAGTGTTT
TTAGATGAATATATGAATGAATTCAAGACTTCAGATTGCACAGCCACAAAGGTGCCAAAA
ACAGAAAGAAAGAAAAGAAGGAAAAAGGAAACTGATTTGGTGGAAGAACACAATGGTCAC
ATCTTTAAAGCCACCCAATATAGCATCCCTACATACTGTGAATACTGTTCTTCTTTGATA
TGGATAATGGACCGAGCCTCTGTTTGCAAATTATGCAAGTATGCTTGCCATAAGAAGTGC
TGTCTGAAAACCACAGCCAAGTGCTCTAAAAAGTATGATCCAGAGCTGTCATCTCGACAA
TTTGGGGTTGAACTGTCCCGTTTGACCAGTGAAGACCGAACTGTTCCTTTAGTAGTGGAA
AAGCTCATAAACTACATTGAAATGCATGGACTGTATACAGAAGGTATTTATCGAAAGTCT
GGTTCGACTAATAAAATCAAGGAGCTTCGGCAGGGTCTAGATACAGATGCTGAGAGTGTA
AATCTAGATGACTATAACATACACGTCATTGCAAGTGTATTCAAACAATGGCTTCGAGAT
TTGCCCAATCCTCTCATGACCTTTGAACTCTATGAGGAATTTCTTCGAGCTATGGGCCTT
CAGGAGAGGAAGGAGACAATCCGTGGTGTATACTCTGTGATTGATCAACTCTCCCGAACT
CATCTCAATACACTGGAACGCCTCATCTTTCATCTAGTCAGGATTGCTCTGCAGGAAGAC
ACTAATCGAATGTCTGCTAATGCTTTGGCCATTGTGTTTGCGCCCTGCATTCTCCGCTGC
CCTGACACCACTGACCCACTACAAAGTGTACAGGACATCAGTAAGACTACCACTTGTGTG
GAACTGATTGTTGTGGAACAAATGAATAAATACAAGGCTCGTCTCAAAGATATCAGTAGC
TTGGAATTTGCTGAGAATAAGGCAAAGACCAGGTTGTCACTGATTCGTAGATCAATGGGA
AAGGGGCGTATTCGTCGAGGAAACTATCCAGGTCCATCGTCTCCTGTTGTAGTTCGGTTG
CCTTCTGTGTCTGATGTCTCAGAGGAGACCTTGACTAGTGAGGCAGCCATGGAGACTGAC
ATCACAGAACAGCAGCAAGCAGCTATGCAGCAGGAGGAGAGAGTACTGACTGAGCAGATT
GAGAACCTACAGAAGGAGAAGGAGGAGCTAACATTTGAGATGCTTGTACTGGAACCCCGT
GCCTCTGATGATGAAACCCTTGAGTCTGAGGCCTCCATTGGGACTGCTGATAGCTCAGAG
AATTTGAATATGGAGTCTGAATATGCTATCTCTGAGAAATCAGAAAGAAGCTTAGCCCTT
AGCTCCCTGAAGACAGCTGGCAAGTCTGAACCTTCCAGCAAGTTGCGAAAGCAACTTAAA
AAGCAGCAAGACTCTTTAGATGTCGTGGACTCTTCGGTCTCCTCTTTATGTCTGTCTAAC
ACGGCATCATCTCATGGGACCAGAAAACTATTTCAGATTTATTCCAAATCTCCATTCTAC
CGAGCTGCCTCAGGTAATGAGGCCCTGGGAATGGAAGGACCATTGGGCCAGACCAAATTC
CTGGAAGACAAGCCTCAGTTCATCAGCAGAGGAACCTTCAACCCGGAAAAGGGCAAACAA
AAATTAAAGAATGTGAAAAACTCACCTCAGAAAACCAAAGAGACCCCAGAGGGGACAGTC
ATGTCTGGCCGCAGAAAAACTGTGGACCCAGACTGCACCTCCAACCAACAGCTAGCACTC
TTTGGAAATAATGAATTTATGGTCTGA
Protein Properties
Number of Residues 2548
Molecular Weight 292703.0
Theoretical pI 9.22
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["175-195"]
Protein Sequence
>Myosin-IXa
MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKC
YVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGS
LQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVG
SILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGE
SGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFI
QVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEE
YHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIF
SLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGE
KLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFG
FEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLIS
KKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYG
VKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGK
RNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSD
LQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGIL
TRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSK
LMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQD
FVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVL
RRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAAL
LQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRK
KIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFD
NRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLE
DLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRG
TPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNET
SSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQ
RNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEER
QKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSL
LSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKEL
SKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIP
LVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKL
AVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDE
LAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIAS
VSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSI
RYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPK
TERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKC
CLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKS
GSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGL
QERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRC
PDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMG
KGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQI
ENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLAL
SSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFY
RAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTV
MSGRRKTVDPDCTSNQQLALFGNNEFMV
GenBank ID Protein 156119615
UniProtKB/Swiss-Prot ID B2RTY4
UniProtKB/Swiss-Prot Entry Name MYO9A_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_006901.2
GeneCard ID MYO9A
GenAtlas ID MYO9A
HGNC ID HGNC:7608
References
General References Not Available