Showing Protein Voltage-gated hydrogen channel 1 (CDBP04921)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04921
Secondary Accession Numbers Not Available
Name Voltage-gated hydrogen channel 1
Description Not Available
Synonyms
  1. HV1
  2. Hydrogen voltage-gated channel 1
  3. Voltage sensor domain-only protein
Gene Name HVCN1
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis
GO Classification
Component
cell part
membrane
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.11
SNPs HVCN1
Gene Sequence 
>822 bp
ATGGCCACCTGGGACGAAAAGGCAGTCACCCGCAGGGCCAAGGTGGCTCCCGCTGAGAGG
ATGAGCAAGTTCTTAAGGCACTTCACGGTCGTGGGAGACGACTACCATGCCTGGAACATC
AACTACAAGAAATGGGAGAATGAAGAGGAGGAGGAGGAGGAGGAGCAGCCACCACCCACA
CCAGTCTCAGGCGAGGAAGGCAGAGCTGCAGCCCCTGACGTTGCCCCTGCCCCTGGCCCC
GCACCCAGGGCCCCCCTTGACTTCAGGGGCATGTTGAGGAAACTGTTCAGCTCCCACAGG
TTTCAGGTCATCATCATCTGCTTGGTGGTTCTGGATGCCCTCCTGGTGCTTGCTGAGCTC
ATCCTGGACCTGAAGATCATCCAGCCCGACAAGAATAACTATGCTGCCATGGTATTCCAC
TACATGAGCATCACCATCTTGGTCTTTTTTATGATGGAGATCATCTTTAAATTATTTGTC
TTCCGCCTGGAGTTCTTTCACCACAAGTTTGAGATCCTGGATGCCGTCGTGGTGGTGGTC
TCATTCATCCTCGACATTGTCCTCCTGTTCCAGGAGCACCAGTTTGAGGCTCTGGGCCTG
CTGATTCTGCTCCGGCTGTGGCGGGTGGCCCGGATCATCAATGGGATTATCATCTCAGTT
AAGACACGTTCAGAACGGCAACTCTTAAGGTTAAAACAGATGAATGTACAATTGGCCGCC
AAGATTCAACACCTTGAGTTCAGCTGCTCTGAGAAGGAACAAGAAATTGAAAGACTTAAC
AAACTATTGCGACAGCATGGACTTCTTGGTGAAGTGAACTAG
Protein Properties
Number of Residues 273
Molecular Weight 31682.9
Theoretical pI 6.8
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["101-121", "136-156", "170-190", "198-218"]
Protein Sequence 
>Voltage-gated hydrogen channel 1
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT
PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL
ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV
SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA
KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
GenBank ID Protein 91992153
UniProtKB/Swiss-Prot ID Q96D96
UniProtKB/Swiss-Prot Entry Name HVCN1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001040107.1
GeneCard ID HVCN1
GenAtlas ID HVCN1
HGNC ID HGNC:28240
References
General References Not Available