| Identification |
|---|
| HMDB Protein ID
| CDBP04914 |
| Secondary Accession Numbers
| Not Available |
| Name
| Zinc finger transcription factor Trps1 |
| Description
| Not Available |
| Synonyms
|
- Tricho-rhino-phalangeal syndrome type I protein
- Zinc finger protein GC79
|
| Gene Name
| TRPS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| biological regulation |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q24.12 |
| SNPs
| TRPS1 |
| Gene Sequence
|
>3846 bp
ATGGTCCGGAAAAAGAACCCCCCTCTGAGAAACGTTGCAAGTGAAGGCGAGGGCCAGATC
CTGGAGCCTATAGGTACAGAAAGCAAGGTATCTGGAAAGAACAAAGAATTCTCTGCAGAT
CAGATGTCAGAAAATACGGATCAGAGTGATGCTGCAGAACTAAATCATAAGGAGGAACAT
AGCTTGCATGTTCAAGATCCATCTTCTAGCAGTAAGAAGGACTTGAAAAGCGCAGTTCTG
AGTGAGAAGGCTGGCTTCAATTATGAAAGCCCCAGTAAGGGAGGAAACTTTCCCTCCTTT
CCGCATGATGAGGTGACAGACAGAAATATGTTGGCTTTCTCATTTCCAGCTGCTGGGGGA
GTCTGTGAGCCCTTGAAGTCTCCGCAAAGAGCAGAGGCAGATGACCCTCAAGATATGGCC
TGCACCCCCTCAGGGGACTCACTGGAGACAAAGGAAGATCAGAAGATGTCACCAAAGGCT
ACAGAGGAAACAGGGCAAGCACAGAGTGGTCAAGCCAATTGTCAAGGTTTGAGCCCAGTT
TCAGTGGCCTCAAAAAACCCACAAGTGCCTTCAGATGGGGGTGTAAGACTGAATAAATCC
AAAACTGACTTACTGGTGAATGACAACCCAGACCCGGCACCTCTGTCTCCAGAGCTTCAG
GACTTTAAATGCAATATCTGTGGATATGGTTACTACGGCAACGACCCCACAGATCTGATT
AAGCACTTCCGAAAGTATCACTTAGGACTGCATAACCGCACCAGGCAAGATGCTGAGCTG
GACAGCAAAATCTTGGCCCTTCATAACATGGTGCAGTTCAGCCATTCCAAAGACTTCCAG
AAGGTCAACCGTTCTGTGTTTTCTGGTGTGCTGCAGGACATCAATTCTTCAAGGCCTGTT
TTACTAAATGGGACCTATGATGTGCAGGTGACTTCAGGTGGAACATTCATTGGCATTGGA
CGGAAAACACCAGATTGCCAAGGGAACACCAAGTATTTCCGCTGTAAATTCTGCAATTTC
ACTTATATGGGCAACTCATCCACCGAATTAGAACAACATTTTCTTCAGACTCACCCAAAC
AAAATAAAAGCTTCTCTCCCCTCCTCTGAGGTTGCAAAACCTTCAGAGAAAAACTCTAAC
AAGTCCATCCCTGCACTTCAATCCAGTGATTCTGGAGACTTGGGAAAATGGCAGGACAAG
ATAACAGTCAAAGCAGGAGATGACACTCCTGTTGGGTACTCAGTGCCCATAAAGCCCCTC
GATTCCTCTAGACAAAATGGTACAGAGGCCACCAGTTACTACTGGTGTAAATTTTGTAGT
TTCAGCTGTGAGTCATCTAGCTCACTTAAACTGCTAGAACATTATGGCAAGCAGCACGGA
GCAGTGCAGTCAGGCGGCCTTAATCCAGAGTTAAATGATAAGCTTTCCAGGGGCTCTGTC
ATTAATCAGAATGATCTAGCCAAAAGTTCAGAAGGAGAGACAATGACCAAGACAGACAAG
AGCTCGAGTGGGGCTAAAAAGAAGGACTTCTCCAGCAAGGGAGCCGAGGATAATATGGTA
ACGAGCTATAATTGTCAGTTCTGTGACTTCCGATATTCCAAAAGCCATGGCCCTGATGTA
ATTGTAGTGGGGCCACTTCTCCGTCATTATCAACAGCTCCATAACATTCACAAGTGTACC
ATTAAACACTGTCCATTCTGTCCCAGAGGACTTTGCAGCCCAGAAAAGCACCTTGGAGAA
ATTACTTATCCGTTTGCTTGTAGAAAAAGTAATTGTTCCCACTGTGCACTCTTGCTTCTG
CACTTGTCTCCTGGGGCGGCTGGAAGCTCGCGAGTCAAACATCAGTGCCATCAGTGTTCA
TTCACCACCCCTGACGTAGATGTACTCCTCTTTCACTATGAAAGTGTGCATGAGTCCCAA
GCATCGGATGTCAAACAAGAAGCAAATCACCTGCAAGGATCGGATGGGCAGCAGTCTGTC
AAGGAAAGCAAAGAACACTCATGTACCAAATGTGATTTTATTACCCAAGTGGAAGAAGAG
ATTTCCCGACACTACAGGAGAGCACACAGCTGCTACAAATGCCGTCAGTGCAGTTTTACA
GCTGCCGATACTCAGTCACTACTGGAGCACTTCAACACTGTTCACTGCCAGGAACAGGAC
ATCACTACAGCCAACGGCGAAGAGGACGGTCATGCCATATCCACCATCAAAGAGGAGCCC
AAAATTGACTTCAGGGTCTACAATCTGCTAACTCCAGACTCTAAAATGGGAGAGCCAGTT
TCTGAGAGTGTGGTGAAGAGAGAGAAGCTGGAAGAGAAGGACGGGCTCAAAGAGAAAGTT
TGGACCGAGAGTTCCAGTGATGACCTTCGCAATGTGACTTGGAGAGGGGCAGACATCCTG
CGGGGGAGTCCGTCATACACCCAAGCAAGCCTGGGGCTGCTGACGCCTGTGTCTGGCACC
CAAGAGCAGACAAAGACTCTAAGGGATAGTCCCAATGTGGAGGCCGCCCATCTGGCGCGA
CCTATTTATGGCTTGGCTGTGGAAACCAAGGGATTCCTGCAGGGGGCGCCAGCTGGCGGA
GAGAAGTCTGGGGCCCTCCCCCAGCAGTATCCTGCATCGGGAGAAAACAAGTCCAAGGAT
GAATCCCAGTCCCTGTTACGGAGGCGTAGAGGCTCCGGTGTTTTTTGTGCCAATTGCCTG
ACCACAAAGACCTCTCTCTGGCGAAAGAATGCAAATGGCGGATATGTATGCAACGCGTGT
GGCCTCTACCAGAAGCTTCACTCGACTCCCAGGCCTTTAAACATCATTAAACAAAACAAC
GGTGAGCAGATTATTAGGAGGAGAACAAGAAAGCGCCTTAACCCAGAGGCACTTCAGGCT
GAGCAGCTCAACAAACAGCAGAGGGGCAGCAATGAGGAGCAAGTCAATGGAAGCCCGTTA
GAGAGGAGGTCAGAAGATCATCTAACTGAAAGTCACCAGAGAGAAATTCCACTCCCCAGC
CTAAGTAAATACGAAGCCCAGGGTTCATTGACTAAAAGCCATTCTGCTCAGCAGCCAGTC
CTGGTCAGCCAAACTCTGGATATTCACAAAAGGATGCAACCTTTGCACATTCAGATAAAA
AGTCCTCAGGAAAGTACTGGAGATCCAGGAAATAGTTCATCCGTATCTGAAGGGAAAGGA
AGTTCTGAGAGAGGCAGTCCTATAGAAAAGTACATGAGACCTGCGAAACACCCAAATTAT
TCACCACCAGGCAGCCCTATTGAAAAGTACCAGTACCCACTTTTTGGACTTCCCTTTGTA
CATAATGACTTCCAGAGTGAAGCTGATTGGCTGCGGTTCTGGAGTAAATATAAGCTCTCC
GTTCCTGGGAATCCGCACTACTTGAGTCACGTGCCTGGCCTACCAAATCCTTGCCAAAAC
TATGTGCCTTATCCCACCTTCAATCTGCCTCCTCATTTTTCAGCTGTTGGATCAGACAAT
GACATTCCTCTAGATTTGGCGATCAAGCATTCCAGACCTGGGCCAACTGCAAACGGTGCC
TCCAAGGAGAAAACGAAGGCACCACCAAATGTAAAAAATGAAGGTCCCTTGAATGTAGTA
AAAACAGAGAAAGTTGATAGAAGTACTCAAGATGAACTTTCAACAAAATGTGTGCACTGT
GGCATTGTCTTTCTGGATGAAGTGATGTATGCTTTGCATATGAGTTGCCATGGTGACAGT
GGACCTTTCCAGTGCAGCATATGCCAGCATCTTTGCACGGACAAATATGACTTCACAACA
CATATCCAGAGGGGCCTGCATAGGAACAATGCACAAGTGGAAAAAAATGGAAAACCTAAA
GAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1281 |
| Molecular Weight
| 141519.8 |
| Theoretical pI
| 7.61 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Zinc finger transcription factor Trps1
MVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEH
SLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGG
VCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQAQSGQANCQGLSPV
SVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLI
KHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPV
LLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPN
KIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPL
DSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSV
INQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDV
IVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLL
HLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSV
KESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQD
ITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKV
WTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLAR
PIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCL
TTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQA
EQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPV
LVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNY
SPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQN
YVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVV
KTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTT
HIQRGLHRNNAQVEKNGKPKE
|
| External Links |
|---|
| GenBank ID Protein
| 6684534 |
| UniProtKB/Swiss-Prot ID
| Q9UHF7 |
| UniProtKB/Swiss-Prot Entry Name
| TRPS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF183810 |
| GeneCard ID
| TRPS1 |
| GenAtlas ID
| TRPS1 |
| HGNC ID
| HGNC:12340 |
| References |
|---|
| General References
| Not Available |