Cannabis Compound Database: Showing Protein Zinc finger protein PLAG1 (CDBP04908)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP04908

Secondary Accession Numbers

Not Available

Name

Zinc finger protein PLAG1

Description

Not Available

Synonyms

Pleiomorphic adenoma gene 1 protein

Gene Name

PLAG1

Protein Type

Metal Binding

Biological Properties

General Function

Involved in zinc ion binding

Specific Function

Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation:when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia

GO Classification

Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
nucleic acid binding

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:8

Locus

8q12

SNPs

PLAG1

Gene Sequence

>1503 bp
ATGGCCACTGTCATTCCTGGTGATTTGTCAGAAGTAAGAGATACCCAGAAAGTCCCTTCA
GGGAAACGTAAGCGTGGTGAAACCAAACCAAGAAAAAACTTTCCTTGCCAACTGTGTGAC
AAGGCCTTTAACAGTGTTGAGAAATTAAAGGTTCACTCCTACTCTCACACAGGAGAGAGG
CCCTACAAGTGCATACAACAAGACTGCACCAAGGCCTTTGTTTCTAAGTACAAATTACAA
AGGCACATGGCTACTCATTCTCCTGAGAAAACCCACAAGTGTAATTATTGTGAGAAAATG
TTTCACCGGAAAGATCATCTGAAGAATCACCTCCATACACACGACCCTAACAAAGAGACG
TTTAAGTGCGAAGAATGTGGCAAGAACTACAATACCAAGCTTGGATTTAAACGTCACTTG
GCCTTGCATGCCGCAACAAGTGGTGACCTCACCTGTAAGGTATGTTTGCAAACTTTTGAA
AGCACGGGAGTGCTTCTGGAGCACCTTAAATCTCATGCAGGCAAGTCGTCTGGTGGGGTT
AAAGAAAAAAAGCACCAGTGCGAACATTGTGATCGCCGGTTCTACACCCGAAAGGATGTC
CGGAGACACATGGTGGTGCACACTGGAAGAAAGGACTTCCTCTGTCAGTATTGTGCACAG
AGATTTGGGCGAAAGGATCACCTGACTCGACATATGAAGAAGAGTCACAATCAAGAGCTT
CTGAAGGTCAAAACAGAACCAGTGGATTTCCTTGACCCATTTACCTGCAATGTGTCTGTG
CCTATAAAAGACGAGCTCCTTCCGGTGATGTCCTTACCTTCCAGTGAACTGTTATCAAAG
CCATTCACAAACACTTTGCAGTTAAACCTCTACAACACTCCATTTCAGTCCATGCAGAGC
TCGGGATCTGCCCACCAAATGATCACAACTTTACCTTTGGGAATGACATGCCCAATAGAT
ATGGACACTGTTCATCCCTCTCACCACCTTTCTTTCAAATATCCGTTCAGTTCTACCTCA
TATGCAATTTCTATTCCTGAAAAAGAACAGCCATTAAAGGGGGAAATTGAGAGTTACCTG
ATGGAGTTACAAGGTGGCGTGCCCTCTTCATCCCAAGATTCTCAAGCATCGTCATCATCT
AAGCTAGGGTTGGATCCTCAGATTGGGTCCCTAGATGATGGTGCAGGAGACCTCTCCCTA
TCCAAAAGCTCTATCTCCATCAGTGACCCCCTAAACACACCAGCATTGGATTTTTCTCAG
TTGTTTAATTTCATACCTTTAAATGGTCCTCCCTATAATCCTCTATCAGTGGGGAGCCTT
GGAATGAGCTATTCCCAGGAAGAAGCACATTCTTCTGTTTCCCAGCTCCCCCCACAAACA
CAGGATCTTCAGGATCCTGCAAACACTATAGGGCTTGGGTCTCTGCACTCACTGTCAGCA
GCTTTCACCAGCAGTTTAAGCACAAGTACCACCCTCCCACGTTTCCATCAAGCTTTTCAG
TAG

Protein Properties

Number of Residues

500

Molecular Weight

55909.0

Theoretical pI

8.7

Pfam Domain Function

Not Available

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Zinc finger protein PLAG1
MATVIPGDLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGER
PYKCIQQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKET
FKCEECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGV
KEKKHQCEHCDRRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQEL
LKVKTEPVDFLDPFTCNVSVPIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQS
SGSAHQMITTLPLGMTCPIDMDTVHPSHHLSFKYPFSSTSYAISIPEKEQPLKGEIESYL
MELQGGVPSSSQDSQASSSSKLGLDPQIGSLDDGAGDLSLSKSSISISDPLNTPALDFSQ
LFNFIPLNGPPYNPLSVGSLGMSYSQEEAHSSVSQLPPQTQDLQDPANTIGLGSLHSLSA
AFTSSLSTSTTLPRFHQAFQ

External Links

GenBank ID Protein

167857796

UniProtKB/Swiss-Prot ID

Q6DJT9

UniProtKB/Swiss-Prot Entry Name

PLAG1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001114634.1

GeneCard ID