| Identification |
|---|
| HMDB Protein ID
| CDBP04893 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hyaluronan and proteoglycan link protein 2 |
| Description
| Not Available |
| Synonyms
|
- Brain link protein 1
|
| Gene Name
| HAPLN2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid |
| GO Classification
|
| Function |
| binding |
| pattern binding |
| polysaccharide binding |
| glycosaminoglycan binding |
| hyaluronic acid binding |
| Process |
| cell adhesion |
| cellular process |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q23.1 |
| SNPs
| HAPLN2 |
| Gene Sequence
|
>1023 bp
ATGCCAGGCTGGCTCACCCTCCCCACACTCTGCCGCTTCCTTCTTTGGGCCTTCACCATC
TTCCACAAAGCCCAAGGAGACCCAGCATCCCACCCGGGCCCCCACTACCTCCTGCCCCCC
ATCCACGAGGTCATTCACTCTCATCGTGGGGCCACGGCCACGCTGCCCTGCGTCCTGGGC
ACCACGCCTCCCAGCTACAAGGTGCGCTGGAGCAAGGTGGAGCCTGGGGAGCTCCGGGAA
ACGCTGATCCTCATCACCAACGGACTGCACGCCCGGGGGTATGGGCCCCTGGGAGGGCGC
GCCAGGATGCGGAGGGGGCATCGACTAGACGCCTCCCTGGTCATCGCGGGCGTGCGCCTG
GAGGACGAGGGCCGGTACCGCTGCGAGCTCATCAACGGCATCGAGGACGAGAGCGTGGCG
CTGACCTTGAGCTTGGAGGGTGTGGTGTTTCCGTACCAACCCAGCCGGGGCCGGTACCAG
TTCAATTACTACGAGGCGAAGCAGGCGTGCGAGGAGCAGGACGGACGCCTGGCCACCTAC
TCCCAGCTCTACCAGGCTTGGACCGAGGGTCTGGACTGGTGTAACGCGGGCTGGCTGCTC
GAGGGCTCCGTGCGCTACCCTGTGCTCACCGCACGCGCCCCGTGCGGCGGCCGAGGCCGG
CCCGGGATCCGCAGCTACGGACCCCGCGACCGGATGCGCGACCGCTACGACGCCTTCTGC
TTCACCTCCGCGCTGGCGGGCCAAGTGTTCTTCGTGCCCGGGCGGCTGACGCTGTCTGAA
GCCCACGCGGCGTGCCGGCGACGCGGCGCCGTGGTGGCCAAGGTTGGGCACCTCTACGCC
GCCTGGAAGTTTTCGGGGCTAGACCAGTGCGACGGCGGCTGGCTGGCTGACGGCAGTGTG
CGCTTCCCAATCACCACGCCGAGGCCGCGCTGCGGGGGGCTCCCGGATCCCGGAGTGCGC
AGTTTCGGCTTCCCCAGGCCCCAACAGGCAGCCTATGGGACCTACTGCTACGCCGAGAAT
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 340 |
| Molecular Weight
| 37774.7 |
| Theoretical pI
| 8.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Hyaluronan and proteoglycan link protein 2
MPGWLTLPTLCRFLLWAFTIFHKAQGDPASHPGPHYLLPPIHEVIHSHRGATATLPCVLG
TTPPSYKVRWSKVEPGELRETLILITNGLHARGYGPLGGRARMRRGHRLDASLVIAGVRL
EDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNYYEAKQACEEQDGRLATY
SQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGRGRPGIRSYGPRDRMRDRYDAFC
FTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSV
RFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCYAEN
|
| External Links |
|---|
| GenBank ID Protein
| 11094293 |
| UniProtKB/Swiss-Prot ID
| Q9GZV7 |
| UniProtKB/Swiss-Prot Entry Name
| HPLN2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB049054 |
| GeneCard ID
| HAPLN2 |
| GenAtlas ID
| HAPLN2 |
| HGNC ID
| HGNC:17410 |
| References |
|---|
| General References
| Not Available |