| Identification |
|---|
| HMDB Protein ID
| CDBP04891 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lymphatic vessel endothelial hyaluronic acid receptor 1 |
| Description
| Not Available |
| Synonyms
|
- CRSBP-1
- Cell surface retention sequence-binding protein 1
- Extracellular link domain-containing protein 1
- Hyaluronic acid receptor
- LYVE-1
|
| Gene Name
| LYVE1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes |
| GO Classification
|
| Function |
| binding |
| pattern binding |
| polysaccharide binding |
| glycosaminoglycan binding |
| hyaluronic acid binding |
| Process |
| cell adhesion |
| cellular process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15 |
| SNPs
| LYVE1 |
| Gene Sequence
|
>969 bp
ATGGCCAGGTGCTTCAGCCTGGTGTTGCTTCTCACTTCCATCTGGACTACGAGGCTCCTG
GTCCAAGGCTCTTTGCGTGCAGAAGAGCTTTCCATCCAGGTGTCATGCAGAATTATGGGG
ATCACCCTTGTGAGCAAAAAGGCGAACCAGCAGCTGAATTTCACAGAAGCTAAGGAGGCC
TGTAGGCTGCTGGGACTAAGTTTGGCCGGCAAGGACCAAGTTGACACAGCCTTGAAAGCT
AGCTTTGAAACTTGCAGCTATGGCTGGGTTGGAGATGGATTCGTGGTCATCTCTAGGATT
AGCCCAAACCCCAAGTGTGGGAAAAATGGGGTGGGTGTCCTGATTTGGAAGGTTCCAGTG
AGCCGACAGTTTGGAGCCTATTGTTACAACTCATCTGATACTTGGACTAACTCGCGCATT
CCAGAAATTATCACCACCAAAGATCCCATATTCAACACTCAAACTGCAACACAAACAACA
GAATTTATTGTCAGTGACAGTACCTACTCGGTGGCATCCCCTTACTCTACAATACCTGCC
CCTACTACTACTCCTCCTGCTCCAGCTTCCACTTCTATTCCACGGAGAAAAAAATTGATT
TGTGTCACAGAAGTTTTTATGGAAACTAGCACCATGTCTACAGAAACTGAACCATTTGTT
GAAAATAAAGCAGCATTCAAGAATGAAGCTGCTGGGTTTGGAGGTGTCCCCACGGCTCTG
CTAGTGCTTGCTCTCCTCTTCTTTGGTGCTGCAGCTGGTCTTGGATTTTGCTATGTCAAA
AGGTATGTGAAGGCCTTCCCTTTTACAAACAAGAATCAGCAGAAGGAAATGATCGAAACC
AAAGTAGTAAAGGAGGAGAAGGCCAATGATAGCAACCCTAATGAGGAATCAAAGAAAACT
GATAAAAACCCAGAAGAGTCCAAGAGTCCAAGCAAAACTACCGTGCGATGCCTGGAAGCT
GAAGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 322 |
| Molecular Weight
| 35213.1 |
| Theoretical pI
| 8.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lymphatic vessel endothelial hyaluronic acid receptor 1
MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEA
CRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPV
SRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTTEFIVSDSTYSVASPYSTIPA
PTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTAL
LVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKANDSNPNEESKKT
DKNPEESKSPSKTTVRCLEAEV
|
| External Links |
|---|
| GenBank ID Protein
| 5359673 |
| UniProtKB/Swiss-Prot ID
| Q9Y5Y7 |
| UniProtKB/Swiss-Prot Entry Name
| LYVE1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF118108 |
| GeneCard ID
| LYVE1 |
| GenAtlas ID
| LYVE1 |
| HGNC ID
| HGNC:14687 |
| References |
|---|
| General References
| Not Available |