| Identification |
|---|
| HMDB Protein ID
| CDBP04866 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA-specific adenosine deaminase 1 |
| Description
| Not Available |
| Synonyms
|
- hADAT1
- tRNA-specific adenosine-37 deaminase
|
| Gene Name
| ADAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in RNA binding |
| Specific Function
| Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
|
| GO Classification
|
| Biological Process |
| tRNA processing |
| Function |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| adenosine deaminase activity |
| nucleic acid binding |
| rna binding |
| Molecular Function |
| metal ion binding |
| RNA binding |
| tRNA-specific adenosine deaminase activity |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna processing |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ADAT1 |
| Gene Sequence
|
>1509 bp
ATGTGGACCGCGGATGAGATTGCTCAGCTATGCTATGAACACTATGGGATCAGGCTGCCC
AAGAAGGGGAAGCCTGAGCCAAACCATGAGTGGACATTATTGGCAGCGGTGGTGAAGATA
CAATCTCCAGCTGACAAGGCCTGCGACACCCCTGATAAGCCGGTGCAAGTGACAAAGGAA
ATTGTGTCAATGGGAACAGGAACAAAATGCATAGGACAGTCCAAAATGAGGAAGAACGGA
GACATCCTCAATGATAGCCATGCTGAGGTCATAGCCAGAAGGAGTTTCCAAAGGTACCTT
CTCCACCAACTCCAGTTGGCAGCCACCCTGAAAGAGGATAGCATCTTTGTCCCAGGAACT
CAAAAAGGAGTGTGGAAACTTAGACGAGACCTCATTTTTGTGTTTTTCTCCAGCCATACA
CCCTGTGGGGATGCCTCCATCATTCCGATGCTTGAGTTTGAAGATCAGCCTTGCTGTCCT
GTCTTCAGAAATTGGGCCAACAACTCATCAGTAGAAGCCAGTAGTAACCTGGAAGCTCCT
GGAAATGAAAGAAAATGTGAAGACCCTGACAGTCCTGTAACCAAAAAGATGAGGCTTGAG
CCTGGGACTGCAGCCAGGGAGGTCACCAACGGAGCAGCTCACCATCAGAGTTTTGGCAAG
CAGAAAAGTGGCCCAATCTCACCAGGCATCCACAGCTGTGATCTCACTGTAGAGGGACTG
GCTACTGTCACCAGAATAGCCCCTGGTAGTGCCAAAGTGACAGACGTTTATAGAACTGGA
GCCAAGTGTGTACCTGGAGAAGCTGGAGACTCCGGAAAGCCGGGTGCTGCGTTTCACCAG
GTGGGGCTGCTCCGAGTGAAGCCAGGCCGTGGAGACAGAACACGCTCCATGTCCTGTAGT
GACAAGATGGCCCGATGGAACGTCCTCGGATGCCAAGGGGCACTGTTGATGCACTTGCTG
GAAGAGCCCATCTACCTGTCAGCTGTGGTCATTGGGAAGTGCCCATACAGCCAGGAAGCC
ATGCAGAGAGCACTGATTGGAAGGTGTCAGAATGTGTCTGCTTTACCAAAAGGCTTCGGA
GTTCAAGAATTAAAAATACTGCAGTCAGATTTACTATTTGAACAGAGCCGCAGTGCGGTG
CAGGCAAAAAGGGCTGATAGCCCAGGTCGACTTGTTCCTTGTGGGGCAGCCATCAGCTGG
AGTGCAGTTCCTGAGCAGCCTTTGGATGTTACTGCCAATGGCTTTCCACAGGGAACAACA
AAGAAAACAATTGGAAGCCTTCAGGCAAGATCCCAAATCAGCAAAGTGGAACTCTTCAGA
TCATTCCAGAAGCTGCTAAGCAGAATTGCAAGGGACAAGTGGCCACACTCCCTCAGGGTG
CAGAAGCTGGATACCTACCAGGAGTACAAGGAGGCTGCGTCCTCTTACCAGGAAGCCTGG
AGCACACTCCGGAAGCAGGTGTTTGGATCCTGGATCAGAAACCCACCGGATTATCACCAG
TTCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 502 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>tRNA-specific adenosine deaminase 1
MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKE
VVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGT
QKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAP
GNERKCEDPDSPVTKKMRLEPGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGL
ATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQVGLLRVKPGRGDRTRSMSCS
DKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQNVSALPKGFG
VQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISWSAVPEQPLDVTANGFPQGTT
KKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAW
STLRKQVFGSWIRNPPDYHQFK
|
| External Links |
|---|
| GenBank ID Protein
| 5726241 |
| UniProtKB/Swiss-Prot ID
| Q9BUB4 |
| UniProtKB/Swiss-Prot Entry Name
| ADAT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF125188 |
| GeneCard ID
| ADAT1 |
| GenAtlas ID
| ADAT1 |
| HGNC ID
| HGNC:228 |
| References |
|---|
| General References
| Not Available |