Identification
HMDB Protein ID CDBP04837
Secondary Accession Numbers Not Available
Name Ammonium transporter Rh type C
Description Not Available
Synonyms
  1. Rh family type C glycoprotein
  2. Rh glycoprotein kidney
  3. Rh type C glycoprotein
  4. Rhesus blood group family type C glycoprotein
  5. Tumor-related protein DRC2
Gene Name RHCG
Protein Type Transporter
Biological Properties
General Function Involved in ammonium transmembrane transporter activity
Specific Function Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
GO Classification
Biological Process
cellular ion homeostasis
transepithelial ammonium transport
amine transport
epithelial cell differentiation
regulation of pH
Cellular Component
basolateral plasma membrane
apical plasma membrane
cytoplasmic vesicle
integral to plasma membrane
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
transporter activity
organic cation transmembrane transporter activity
ammonium transmembrane transporter activity
Molecular Function
ammonia transmembrane transporter activity
ammonium transmembrane transporter activity
ankyrin binding
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Multi-pass membrane protein
  2. Apical cell membrane
Pathways
Gene Properties
Chromosome Location 15
Locus 15q25
SNPs RHCG
Gene Sequence
>1440 bp
ATGGCCTGGAACACCAACCTCCGCTGGCGGCTGCCGCTCACCTGCCTGCTCCTGCAGGTG
ATTATGGTGATTCTCTTCGGGGTGTTCGTGCGCTACGACTTCGAGGCCGACGCCCACTGG
TGGTCAGAGAGGACGCACAAGAACTTGAGCGACATGGAGAACGAATTCTACTATCGCTAC
CCAAGCTTCCAGGACGTGCACGTGATGGTCTTCGTGGGCTTCGGCTTCCTCATGACTTTC
CTGCAGCGCTACGGCTTCAGCGCCGTGGGCTTCAACTTCCTGTTGGCAGCCTTCGGCATC
CAGTGGGCGCTGCTCATGCAGGGCTGGTTCCACTTCTTACAAGACCGCTACATCGTCGTG
GGCGTGGAGAACCTCATCAACGCTGACTTCTGCGTGGCCTCTGTCTGCGTGGCCTTTGGG
GCAGTTCTGGGTAAAGTCAGCCCCATTCAGCTGCTCATCATGACTTTCTTCCAAGTGACC
CTCTTCGCTGTGAATGAGTTCATTCTCCTTAACCTGCTAAAGGTGAAGGATGCAGGAGGC
TCCATGACCATCCACACATTTGGCGCCTACTTTGGGCTCACAGTGACCCGGATCCTCTAC
CGACGCAACCTAGAGCAGAGCAAGGAGAGACAGAATTCTGTGTACCAGTCGGACCTCTTT
GCCATGATTGGCACCCTCTTCCTGTGGATGTACTGGCCCAGCTTCAACTCAGCCATATCC
TACCATGGGGACAGCCAGCACCGAGCCGCCATCAACACCTACTGCTCCTTGGCAGCCTGC
GTGCTTACCTCGGTGGCAATATCCAGTGCCCTGCACAAGAAGGGCAAGCTGGACATGGTG
CACATCCAGAATGCCACGCTCGCAGGAGGGGTGGCCGTGGGTACCGCTGCTGAGATGATG
CTCATGCCTTACGGTGCCCTCATCATCGGCTTCGTCTGCGGCATCATCTCCACCCTGGGT
TTTGTATACCTGACCCCATTCCTGGAGTCCCGGCTGCACATCCAGGACACATGTGGCATT
AACAATCTGCATGGCATTCCTGGCATCATAGGCGGCATCGTGGGTGCTGTGACAGCGGCC
TCCGCCAGCCTTGAAGTCTATGGAAAAGAAGGGCTTGTCCATTCCTTTGACTTTCAAGGT
TTCAACGGGGACTGGACCGCAAGAACACAGGGAAAGTTCCAGATTTATGGTCTCTTGGTG
ACCCTGGCCATGGCCCTGATGGGTGGCATCATTGTGGGGCTCATTTTGAGATTACCATTC
TGGGGACAACCTTCAGATGAGAACTGCTTTGAGGATGCGGTCTACTGGGAGATGCCTGAA
GGGAACAGCACTGTCTACATCCCTGAGGACCCCACCTTCAAGCCCTCAGGACCCTCAGTA
CCCTCAGTACCCATGGTGTCCCCACTACCCATGGCTTCCTCGGTACCCTTGGTACCCTAG
Protein Properties
Number of Residues 479
Molecular Weight 53178.56
Theoretical pI 6.39
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ammonium transporter Rh type C
MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRY
PSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVV
GVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGG
SMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAIS
YHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMM
LMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAA
SASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPF
WGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP
GenBank ID Protein 6625732
UniProtKB/Swiss-Prot ID Q9UBD6
UniProtKB/Swiss-Prot Entry Name RHCG_HUMAN
PDB IDs
GenBank Gene ID AF193809
GeneCard ID RHCG
GenAtlas ID RHCG
HGNC ID HGNC:18140
References
General References Not Available