| Identification |
|---|
| HMDB Protein ID
| CDBP04836 |
| Secondary Accession Numbers
| Not Available |
| Name
| RPE-retinal G protein-coupled receptor |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| RGR |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| Process |
| visual perception |
| phototransduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| multicellular organismal process |
| system process |
| neurological system process |
| sensory perception |
| sensory perception of light stimulus |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q23 |
| SNPs
| RGR |
| Gene Sequence
|
>876 bp
ATGGCAGAGACCAGTGCCCTGCCCACTGGCTTCGGGGAGCTCGAGGTGCTGGCTGTGGGG
ATGGTGCTACTGGTGGAAGCTCTCTCCGGTCTCAGCCTCAATACCCTGACCATCTTCTCT
TTCTGCAAGACCCCGGAGCTGCGGACTCCCTGCCACCTACTGGTGCTGAGCTTGGCTCTT
GCGGACAGTGGGATCAGCCTGAATGCCCTCGTTGCAGCCACATCCAGCCTTCTCCGGCGC
TGGCCCTACGGCTCGGACGGCTGCCAGGCTCACGGCTTCCAGGGCTTTGTGACAGCGTTG
GCCAGCATCTGCAGCAGTGCAGCCATCGCATGGGGGCGTTATCACCACTACTGCACCCGT
AGCCAGCTGGCCTGGAACTCAGCCGTCTCTCTGGTGCTCTTCGTGTGGCTGTCTTCTGCC
TTCTGGGCAGCTCTGCCCCTTCTGGGTTGGGGTCACTACGACTATGAGCCACTGGGGACA
TGCTGCACCCTGGACTACTCCAAGGGGGACAGAAACTTCACCAGCTTCCTCTTCACCATG
TCCTTCTTCAACTTCGCCATGCCCCTCTTCATCACGATCACTTCCTACAGTCTCATGGAG
CAGAAACTGGGGAAGAGTGGCCATCTCCAGGTAAACACCACTCTGCCAGCAAGGACGCTG
CTGCTCGGCTGGGGCCCCTATGCCATCCTGTATCTATACGCAGTCATCGCAGACGTGACT
TCCATCTCCCCCAAACTGCAGATGGTGCCCGCCCTCATTGCCAAAATGGTGCCCACGATC
AATGCCATCAACTATGCCCTGGGCAATGAGATGGTCTGCAGGGGAATCTGGCAGTGCCTC
TCACCGCAGAAGAGGGAGAAGGACCGAACCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 291 |
| Molecular Weight
| 31873.8 |
| Theoretical pI
| 8.14 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["16-36", "53-73", "92-112", "131-151", "176-196", "220-240", "248-268"]
|
| Protein Sequence
|
>RPE-retinal G protein-coupled receptor
MAETSALPTGFGELEVLAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLAL
ADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTR
SQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSFLFTM
SFFNFAMPLFITITSYSLMEQKLGKSGHLQVNTTLPARTLLLGWGPYAILYLYAVIADVT
SISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK
|
| External Links |
|---|
| GenBank ID Protein
| 61744454 |
| UniProtKB/Swiss-Prot ID
| P47804 |
| UniProtKB/Swiss-Prot Entry Name
| RGR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001012720.1 |
| GeneCard ID
| RGR |
| GenAtlas ID
| RGR |
| HGNC ID
| HGNC:9990 |
| References |
|---|
| General References
| Not Available |