| Identification |
|---|
| HMDB Protein ID
| CDBP04829 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nuclear receptor coactivator 6 |
| Description
| Not Available |
| Synonyms
|
- ASC-2
- Activating signal cointegrator 2
- Amplified in breast cancer protein 3
- Cancer-amplified transcriptional coactivator ASC-2
- NRC RAP250
- Nuclear receptor coactivator RAP250
- Nuclear receptor-activating protein, 250 kDa
- PPAR-interacting protein
- PRIP
- Peroxisome proliferator-activated receptor-interacting protein
- Thyroid hormone receptor-binding protein
|
| Gene Name
| NCOA6 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in chromatin binding |
| Specific Function
| Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q11 |
| SNPs
| NCOA6 |
| Gene Sequence
|
>6192 bp
ATGGTTTTGGATGACCTTCCAAACTTAGAAGACATCTATACTTCCTTGTGTTCATCAACA
ATGGAAGACTCAGAGATGGATTTTGACTCTGGACTAGAAGATGATGACACAAAAAGTGAT
AGTATTTTGGAGGATTCCACAATTTTTGTGGCCTTCAAAGGAAATATAGATGATAAAGAC
TTCAAATGGAAATTAGATGCAATATTGAAAAACGTGCCCAATTTGTTACACATGGAGTCC
AGCAAGCTAAAAGTACAGAAGGTGGAGCCCTGGAACAGCGTGCGTGTGACATTCAACATC
CCCCGGGAAGCAGCGGAGCGGCTACGGATCCTTGCTCAGAGCAACAACCAGCAGCTTCGG
GATTTAGGGATTCTCTCCGTTCAGATTGAAGGGGAAGGTGCTATTAACCTGGCTTTGGCT
CAGAACCGAAGCCAAGATGTGAGAATGAATGGACCCATGGGAGCTGGAAATTCAGTTAGG
ATGGAGGCGGGATTTCCTATGGCAAGTGGTCCAGGAATAATAAGGATGAACAACCCTGCC
ACTGTTATGATACCCCCGGGTGGAAATGTGTCATCTTCCATGATGGCACCAGGCCCCAAT
CCAGAGCTGCAGCCCAGGACTCCTCGCCCTGCTTCTCAGTCAGATGCAATGGATCCACTC
CTCTCTGGGCTCCATATACAGCAGCAAAGTCATCCCTCAGGATCTTTAGCTCCCCCACAT
CACCCAATGCAGCCTGTCTCTGTGAACAGACAAATGAACCCAGCTAATTTTCCCCAGCTG
CAGCAGCAGCAGCAACAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAACAACAGCAA
CAGCAGCAACAACAGTTGCAGGCAAGACCCCCACAGCAACATCAGCAGCAACAGCCACAG
GGAATTCGACCCCAGTTTACTGCCCCAACTCAGGTGCCTGTTCCTCCAGGCTGGAACCAG
CTGCCTTCTGGAGCCCTTCAACCTCCTCCAGCCCAGGGTTCTCTGGGCACAATGACTGCA
AACCAAGGGTGGAAGAAGGCTCCCTTGCCCGGCCCAATGCAACAGCAACTCCAGGCAAGA
CCATCCTTAGCCACGGTACAGACGCCTTCCCACCCTCCCCCTCCATATCCCTTTGGCAGC
CAGCAAGCCTCACAAGCCCACACAAACTTTCCTCAGATGAGCAACCCAGGCCAGTTCACA
GCTCCTCAGATGAAGAGTTTGCAGGGAGGGCCCTCTAGGGTCCCAACTCCCTTGCAGCAG
CCCCACCTCACCAACAAGTCTCCTGCCTCCTCACCCTCCTCCTTCCAGCAGGGATCCCCT
GCATCCTCCCCAACGGTTAACCAAACTCAGCAGCAGATGGGACCAAGGCCACCTCAAAAT
AACCCACTTCCCCAGGGATTTCAGCAGCCTGTCAGCTCTCCGGGTCGGAATCCTATGGTT
CAACAGGGAAATGTGCCACCTAACTTCATGGTGATGCAGCAGCAACCACCAAACCAGGGG
CCACAGAGTTTACATCCAGGCCTAGGAGGAATGCCTAAACGCCTCCCACCTGGCTTCTCA
GCAGGACAGGCCAATCCGAACTTTATGCAAGGTCAGGTGCCTTCGACCACAGCAACCACC
CCTGGGAATTCAGGAGCCCCTCAGCTGCAAGCAAATCAAAATGTCCAGCATGCAGGTGGT
CAAGGAGCTGGTCCTCCTCAAAACCAGATGCAGGTGTCCCACGGGCCGCCAAATATGATG
CAGCCCAGCCTCATGGGAATTCATGGCAACATGAACAATCAGCAGGCTGGTACTTCTGGG
GTTCCTCAAGTGAACCTCAGCAACATGCAAGGCCAGCCCCAGCAGGGCCCACCATCTCAG
CTGATGGGCATGCACCAGCAAATCGTGCCCTCCCAGGGCCAGATGGTCCAGCAACAAGGA
ACCTTGAACCCTCAGAACCCTATGATCCTTTCAAGGGCCCAGCTTATGCCACAGGGCCAG
ATGATGGTGAACCCCCCGAGCCAAAATCTTGGGCCCTCGCCCCAAAGGATGACCCCACCC
AAGCAGATGCTTTCCCAGCAGGGCCCACAAATGATGGCGCCACATAACCAGATGATGGGG
CCTCAGGGGCAGGTTTTGCTCCAACAGAACCCAATGATAGAGCAGATTATGACCAATCAA
ATGCAGGGGAATAAGCAGCAGTTTAACACTCAGAACCAGTCCAATGTCATGCCGGGACCA
GCCCAGATAATGAGGGGACCAACTCCGAACATGCAAGGAAATATGGTGCAGTTTACGGGA
CAGATGTCAGGACAGATGCTGCCCCAGCAAGGGCCTGTGAACAACAGTCCATCTCAGGTT
ATGGGCATTCAGGGACAGGTCCTGCGGCCACCAGGGCCCAGCCCACACATGGCCCAGCAG
CATGGTGATCCTGCTACTACAGCAAATAACGATGTCAGTTTATCTCAGATGATGCCTGAT
GTTAGCATTCAACAAACCAACATGGTCCCCCCTCATGTGCAGGCCATGCAGGGAAACAGT
GCCTCGGGAAACCACTTCTCAGGCCATGGGATGTCTTTCAATGCACCTTTCAGTGGAGCT
CCCAATGGAAATCAGATGTCCTGTGGTCAAAATCCAGGCTTCCCAGTCAATAAGGATGTC
ACGCTAACGAGCCCATTGTTGGTCAACTTATTGCAGAGTGACATATCTGCAGGCCATTTT
GGGGTAAACAATAAGCAAAATAATACCAACGCAAATAAACCGAAGAAGAAGAAACCCCCT
CGGAAGAAGAAAAATAGTCAGCAAGATCTAAACACCCCAGATACTCGCCCAGCTGGTCTG
GAAGAGGCTGATCAGCCACCGTTGCCTGGAGAACAAGGAATTAGCTTGGATAACTCAGGC
CCTAAACTGCCAGAATTTTCAAACCGGCCACCAGGTTATCCTTCTCAACCAGTTGAACAG
AGGCCACTTCAGCAGATGCCTCCTCAACTCATGCAGCATGTGGCACCCCCACCACAGCCA
CCACAGCAGCAGCCACAGCCACAACTGCCTCAGCAGCAGCAGCCACCACCTCCCAGTCAG
CCACAGTCTCAGCAGCAGCAGCAGCAGCAGCAACAAATGATGATGATGCTCATGATGCAG
CAGGATCCCAAATCAGTTAGGCTTCCAGTCTCTCAAAATGTCCATCCTCCAAGGGGCCCC
CTGAACCCCGACTCCCAGAGAATGCCCATGCAACAGAGTGGCAGTGTGCCTGTCATGGTC
AGTCTGCAAGGACCTGCCTCCGTGCCACCATCACCTGATAAACAAAGAATGCCAATGCCT
GTGAATACTCCCTTGGGAAGCAATTCAAGGAAAATGGTCTATCAGGAGAGCCCGCAGAAT
CCTTCCAGCTCGCCACTGGCGGAGATGGCCTCACTCCCTGAAGCAAGTGGCAGTGAAGCA
CCATCTGTCCCAGGAGGCCCAAACAACATGCCTTCACATGTAGTACTTCCCCAGAATCAG
TTAATGATGACAGGGCCAAAACCTGGACCATCGCCCCTTTCAGCAACTCAAGGTGCAACT
CCCCAGCAACCCCCTGTAAATTCCCTGCCCAGCTCTCACGGCCACCACTTCCCAAATGTG
GCTGCGCCAACCCAGACATCTAGGCCCAAAACACCAAACAGAGCCAGCCCCAGACCCTAT
TATCCTCAGACACCCAACAACCGCCCTCCCAGCACAGAACCTTCAGAAATCAGTCTGTCA
CCAGAAAGACTCAATGCCTCCATAGCAGGACTCTTCCCTCCACAGATTAATATTCCTTTA
CCTCCTAGGCCAAATTTAAACAGGGGCTTTGATCAACAAGGCCTAAATCCAACAACTTTG
AAGGCCATCGGGCAAGCACCTTCAAATCTTACCATGAATCCTTCCAATTTTGCTACCCCA
CAAACTCACAAATTAGATTCTGTGGTAGTGAATTCTGGAAAGCAGTCTAATTCTGGAGCA
ACAAAACGGGCAAGTCCAAGCAACAGTCGCAGGTCTAGTCCTGGGTCCAGTAGGAAAACC
ACTCCAAGCCCTGGGAGGCAAAATTCAAAAGCCCCTAAACTTACTCTGGCCTCTCAGACA
AATGCAGCCCTATTGCAGAATGTGGAGTTGCCGAGAAATGTATTGGTCAGTCCCACTCCT
CTGGCCAATCCCCCTGTACCTGGGAGCTTTCCTAACAACAGTGGGCTGAATCCTCAGAAT
TCTACTGTGTCTGTGGCTGCAGTTGGGGGTGTTGTTGAGGATAACAAGGAGAGCTTGAAT
GTGCCTCAGGACAGTGATTGCCAGAATTCCCAGAGTAGGAAGGAACAGGTAAACATTGAA
CTAAAAGCAGTCCCTGCCCAAGAAGTTAAAATGGTTGTCCCTGAAGATCAGTCCAAAAAG
GATGGGCAGCCTTCGGATCCTAACAAACTTCCCAGTGTCGAAGAGAACAAAAATTTGGTG
TCTCCTGCTATGAGGGAAGCACCAACATCGTTAAGTCAACTTCTTGACAACTCTGGAGCT
CCCAATGTGACAATTAAACCCCCTGGGCTTACAGATCTGGAAGTAACACCTCCAGTAGTT
TCTGGGGAGGACCTCAAAAAAGCATCTGTCATTCCCACACTGCAGGATCTGTCTTCTTCT
AAAGAACCTTCTAATTCCCTAAACTTACCTCACAGTAATGAGCTGTGTTCATCCCTTGTG
CATCCCGAATTGAGTGAGGTCAGTTCTAACGTTGCACCAAGCATCCCTCCAGTAATGTCA
AGACCTGTTAGCTCTTCCTCCATTTCCACTCCCTTGCCCCCAAATCAAATAACTGTATTT
GTCACTTCCAATCCCATCACAACTTCAGCTAACACATCAGCAGCTTTGCCAACTCACTTG
CAGTCTGCATTGATGTCAACAGTTGTCACAATGCCCAATGCGGGTAGCAAGGTTATGGTT
TCTGAGGGACAGTCAGCTGCTCAGTCTAATGCCCGGCCTCAGTTCATTACACCTGTCTTT
ATCAATTCATCCTCAATAATTCAGGTTATGAAAGGATCACAGCCAAGCACAATTCCTGCA
GCCCCACTGACAACCAACTCTGGCCTGATGCCTCCCTCTGTTGCAGTTGTTGGCCCTTTA
CACATACCTCAGAACATAAAATTTTCTTCTGCTCCTGTACCGCCTAATGCCCTCTCCAGT
AGTCCTGCTCCAAACATCCAGACAGGTCGACCTTTGGTCCTTAGCTCACGAGCCACCCCT
GTTCAGCTTCCTTCCCCTCCTTGTACGTCTTCTCCAGTTGTCCCTTCTCATCCCCCTGTG
CAGCAAGTGAAAGAATTGAATCCAGATGAGGCTAGCCCTCAGGTGAACACCTCAGCAGAT
CAGAACACTCTTCCCTCTTCACAGTCAACCACAATGGTTTCTCCCCTTTTGACCAATAGT
CCAGGGTCCTCTGGCAACCGGCGAAGCCCAGTCTCGTCTAGTAAGGGCAAAGGAAAAGTG
GACAAAATTGGCCAAATTTTGTTGACCAAGGCATGTAAGAAAGTTACAGGCTCTCTTGAG
AAAGGGGAAGAACAATATGGTGCAGATGGAGAGACTGAAGGCCAAGGGCTAGACACCACA
GCTCCGGGGCTCATGGGAACAGAGCAGTTATCCACAGAGCTGGACAGTAAAACCCCAACG
CCCCCAGCACCCACTCTGCTAAAAATGACCTCTAGCCCTGTGGGCCCGGGCACTGCCTCA
GCAGGACCCAGCTTACCTGGCGGTGCTCTCCCCACCAGTGTACGCTCGATAGTAACCACT
CTGGTACCCTCCGAGCTCATCTCCGCCGTACCGACCACAAAAAGCAATCATGGTGGCATA
GCATCTGAGTCACTTGCGGGTGGCCTAGTGGAGGAGAAGGTGGGATCCCATCCAGAACTT
CTACCCAGCATAGCCCCGTCGCAGAATTTAGTCTCAAAGGAAACTTCAACCACAGCACTG
CAGGCCTCTGTTGCCAGACCAGAGCTGGAGGTAAATGCTGCCATAGTCTCTGGACAAAGC
AGTGAGCCCAAAGAGATAGTTGAAAAGTCCAAAATCCCAGGCCGAAGAAACTCCCGAACT
GAAGAGCCAACTGTGGCCTCTGAAAGTGTGGAAAATGGACATCGTAAACGATCTTCTCGA
CCTGCTTCAGCCTCCAGCTCTACTAAAGACATAACCAGTGCGGTGCAATCCAAGCGAAGA
AAATCCAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 2063 |
| Molecular Weight
| 219144.8 |
| Theoretical pI
| 10.06 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nuclear receptor coactivator 6
MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKD
FKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLR
DLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPA
TVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPH
HPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQ
GIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQAR
PSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQ
PHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMV
QQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATT
PGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSG
VPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQ
MMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQ
MQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQV
MGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNS
ASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHF
GVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSG
PKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQ
PQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMV
SLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEA
PSVPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNV
AAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPL
PPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGA
TKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTP
LANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQVNIE
LKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGA
PNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLV
HPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHL
QSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPA
APLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATP
VQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQSTTMVSPLLTNS
PGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTT
APGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTT
LVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTAL
QASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSR
PASASSSTKDITSAVQSKRRKSK
|
| External Links |
|---|
| GenBank ID Protein
| 7140574 |
| UniProtKB/Swiss-Prot ID
| Q14686 |
| UniProtKB/Swiss-Prot Entry Name
| NCOA6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF128458 |
| GeneCard ID
| NCOA6 |
| GenAtlas ID
| NCOA6 |
| HGNC ID
| HGNC:15936 |
| References |
|---|
| General References
| Not Available |