| Identification |
|---|
| HMDB Protein ID
| CDBP04826 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eukaryotic translation initiation factor 5A-1-like |
| Description
| Not Available |
| Synonyms
|
- Eukaryotic initiation factor 5A isoform 1-like
- eIF-5A-1-like
- eIF-5A1-like
|
| Gene Name
| EIF5AL1 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in RNA binding |
| Specific Function
| mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation |
| GO Classification
|
| Function |
| ribosome binding |
| rna binding |
| binding |
| nucleic acid binding |
| translation factor activity, nucleic acid binding |
| translation elongation factor activity |
| ribonucleoprotein binding |
| Process |
| regulation of translational termination |
| positive regulation of translational termination |
| regulation of translational elongation |
| metabolic process |
| positive regulation of translational elongation |
| macromolecule metabolic process |
| translational frameshifting |
| posttranscriptional regulation of gene expression |
| regulation of translation |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| macromolecule modification |
| protein modification process |
| peptidyl-amino acid modification |
| peptidyl-lysine modification |
| peptidyl-lysine modification to hypusine |
|
| Cellular Location
|
- Nucleus
- Nucleus
- Cytoplasm
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Cytoplasmic side
- nuclear pore complex
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q22.3 |
| SNPs
| EIF5AL1 |
| Gene Sequence
|
>465 bp
ATGGCAGATGATTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATG
CAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCTGGCCATGTAAGATC
GTGGAGATGTCTGCTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTGGT
ATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGGAT
GTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCA
CTGCTCCAGGACAGCGGGGAGGTACCAGAGGACCTTCGTCTCCCTGAGGGAGACCTTGGC
AAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCC
ATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 154 |
| Molecular Weight
| 16773.0 |
| Theoretical pI
| 4.61 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Eukaryotic translation initiation factor 5A-1-like
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGWPCKIVEMSASKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVPEDLRLPEGDLG
KEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK
|
| External Links |
|---|
| GenBank ID Protein
| 153791632 |
| UniProtKB/Swiss-Prot ID
| Q6IS14 |
| UniProtKB/Swiss-Prot Entry Name
| IF5AL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001099692.1 |
| GeneCard ID
| EIF5AL1 |
| GenAtlas ID
| EIF5AL1 |
| HGNC ID
| HGNC:17419 |
| References |
|---|
| General References
| Not Available |