Showing Protein Eukaryotic translation initiation factor 5A-2 (CDBP04825)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP04825
Secondary Accession Numbers Not Available
Name Eukaryotic translation initiation factor 5A-2
Description Not Available
Synonyms
  1. Eukaryotic initiation factor 5A isoform 2
  2. eIF-5A-2
  3. eIF-5A2
Gene Name EIF5A2
Protein Type Transcription Factor
Biological Properties
General Function Involved in RNA binding
Specific Function mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation
GO Classification
Function
binding
nucleic acid binding
translation factor activity, nucleic acid binding
translation elongation factor activity
ribonucleoprotein binding
ribosome binding
rna binding
Process
regulation of translation
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
macromolecule modification
protein modification process
peptidyl-amino acid modification
peptidyl-lysine modification
peptidyl-lysine modification to hypusine
regulation of translational termination
positive regulation of translational termination
regulation of translational elongation
metabolic process
positive regulation of translational elongation
macromolecule metabolic process
translational frameshifting
posttranscriptional regulation of gene expression
Cellular Location
  1. Nucleus
  2. Nucleus
  3. Cytoplasm
  4. Peripheral membrane protein
  5. Endoplasmic reticulum membrane
  6. Cytoplasmic side
  7. nuclear pore complex
Pathways
Gene Properties
Chromosome Location Chromosome:3
Locus 3q26.2
SNPs EIF5A2
Gene Sequence 
>462 bp
ATGGCAGACGAAATTGATTTCACTACTGGAGATGCCGGGGCTTCCAGCACTTACCCTATG
CAGTGCTCGGCCTTGCGCAAAAACGGCTTCGTGGTGCTCAAAGGACGACCATGCAAAATA
GTGGAGATGTCAACTTCCAAAACTGGAAAGCATGGTCATGCCAAGGTTCACCTTGTTGGA
ATTGATATTTTCACGGGCAAAAAATATGAAGATATTTGTCCTTCTACTCACAACATGGAT
GTTCCAAATATTAAGAGAAATGATTATCAACTGATATGCATTCAAGATGGTTACCTTTCC
CTGCTGACAGAAACTGGTGAAGTTCGTGAGGATCTTAAACTGCCAGAAGGTGAACTAGGC
AAAGAAATAGAGGGAAAATACAATGCAGGTGAAGATGTACAGGTGTCTGTCATGTGTGCA
ATGAGTGAAGAATATGCTGTAGCCATAAAACCCTGCAAATAA
Protein Properties
Number of Residues 153
Molecular Weight 16793.1
Theoretical pI 5.28
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Eukaryotic translation initiation factor 5A-2
MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELG
KEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK
GenBank ID Protein 9799080
UniProtKB/Swiss-Prot ID Q9GZV4
UniProtKB/Swiss-Prot Entry Name IF5A2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF262027
GeneCard ID EIF5A2
GenAtlas ID EIF5A2
HGNC ID HGNC:3301
References
General References Not Available