| Identification |
|---|
| HMDB Protein ID
| CDBP04808 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neutrophil defensin 4 |
| Description
| Not Available |
| Synonyms
|
- Defensin, alpha 4
- HNP-4
- HP-4
|
| Gene Name
| DEFA4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in defense response |
| Specific Function
| Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production |
| GO Classification
|
| Component |
| extracellular region |
| extracellular region part |
| extracellular space |
| Process |
| defense response |
| response to stimulus |
| response to stress |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p23 |
| SNPs
| DEFA4 |
| Gene Sequence
|
>294 bp
ATGAGGATTATCGCCCTCCTCGCTGCTATTCTCTTGGTAGCCCTCCAGGTCCGGGCAGGC
CCACTCCAGGCAAGAGGTGATGAGGCTCCAGGCCAGGAGCAGCGTGGGCCAGAAGACCAG
GACATATCTATTTCCTTTGCATGGGATAAAAGCTCTGCTCTTCAGGTTTCAGGCTCAACA
AGGGGCATGGTCTGCTCTTGCAGATTAGTATTCTGCCGGCGAACAGAACTTCGTGTTGGG
AACTGCCTCATTGGTGGTGTGAGTTTCACATACTGCTGCACGCGTGTCGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 97 |
| Molecular Weight
| 10504.0 |
| Theoretical pI
| 8.11 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Neutrophil defensin 4
MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGST
RGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
|
| External Links |
|---|
| GenBank ID Protein
| 665927 |
| UniProtKB/Swiss-Prot ID
| P12838 |
| UniProtKB/Swiss-Prot Entry Name
| DEF4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U18745 |
| GeneCard ID
| DEFA4 |
| GenAtlas ID
| DEFA4 |
| HGNC ID
| HGNC:2763 |
| References |
|---|
| General References
| Not Available |