| Identification |
|---|
| HMDB Protein ID
| CDBP04801 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sphingosine 1-phosphate receptor 3 |
| Description
| Not Available |
| Synonyms
|
- Endothelial differentiation G-protein coupled receptor 3
- S1P receptor 3
- S1P receptor Edg-3
- S1P3
- Sphingosine 1-phosphate receptor Edg-3
|
| Gene Name
| S1PR3 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis |
| GO Classification
|
| Component |
| integral to membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| Function |
| bioactive lipid receptor activity |
| lysosphingolipid and lysophosphatidic acid receptor activity |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q22.1-q22.2 |
| SNPs
| S1PR3 |
| Gene Sequence
|
>1134 bp
ATGGCAACTGCCCTCCCGCCGCGTCTCCAGCCGGTGCGGGGGAACGAGACCCTGCGGGAG
CATTACCAGTACGTGGGGAAGTTGGCGGGCAGGCTGAAGGAGGCCTCCGAGGGCAGCACG
CTCACCACCGTGCTCTTCTTGGTCATCTGCAGCTTCATCGTCTTGGAGAACCTGATGGTT
TTGATTGCCATCTGGAAAAACAATAAATTTCACAACCGCATGTACTTTTTCATTGGCAAC
CTGGCTCTCTGCGACCTGCTGGCCGGCATCGCTTACAAGGTCAACATTCTGATGTCTGGC
AAGAAGACGTTCAGCCTGTCTCCCACGGTCTGGTTCCTCAGGGAGGGCAGTATGTTCGTG
GCCCTTGGGGCGTCCACCTGCAGCTTACTGGCCATCGCCATCGAGCGGCACTTGACAATG
ATCAAAATGAGGCCTTACGACGCCAACAAGAGGCACCGCGTCTTCCTCCTGATCGGGATG
TGCTGGCTCATTGCCTTCACGCTGGGCGCCCTGCCCATTCTGGGCTGGAACTGCCTGCAC
AATCTCCCTGACTGCTCTACCATCCTGCCCCTCTACTCCAAGAAGTACATTGCCTTCTGC
ATCAGCATCTTCACGGCCATCCTGGTGACCATCGTGATCCTCTACGCACGCATCTACTTC
CTGGTGAAGTCCAGCAGCCGTAAGGTGGCCAACCACAACAACTCGGAGCGGTCCATGGCA
CTGCTGCGGACCGTGGTGATTGTGGTGAGCGTGTTCATCGCCTGCTGGTCCCCACTCTTC
ATCCTCTTCCTCATTGATGTGGCCTGCAGGGTGCAGGCGTGCCCCATCCTCTTCAAGGCT
CAGTGGTTCATCGTGTTGGCTGTGCTCAACTCCGCCATGAACCCGGTCATCTACACGCTG
GCCAGCAAGGAGATGCGGCGGGCCTTCTTCCGTCTGGTCTGCAACTGCCTGGTCAGGGGA
CGGGGGGCCCGCGCCTCACCCATCCAGCCTGCGCTCGACCCAAGCAGAAGTAAATCAAGC
AGCAGCAACAATAGCAGCCACTCTCCGAAGGTCAAGGAAGACCTGCCCCACACAGACCCC
TCATCCTGCATCATGGACAAGAACGCAGCACTTCAGAATGGGATCTTCTGCAAC
|
| Protein Properties |
|---|
| Number of Residues
| 378 |
| Molecular Weight
| 42249.8 |
| Theoretical pI
| 10.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["41-65", "73-101", "116-134", "154-179", "196-216", "244-265", "282-302"]
|
| Protein Sequence
|
>Sphingosine 1-phosphate receptor 3
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
|
| External Links |
|---|
| GenBank ID Protein
| 2668612 |
| UniProtKB/Swiss-Prot ID
| Q99500 |
| UniProtKB/Swiss-Prot Entry Name
| S1PR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF022139 |
| GeneCard ID
| S1PR3 |
| GenAtlas ID
| S1PR3 |
| HGNC ID
| HGNC:3167 |
| References |
|---|
| General References
| Not Available |