| Identification |
|---|
| HMDB Protein ID
| CDBP04788 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aquaporin-4 |
| Description
| Not Available |
| Synonyms
|
- AQP-4
- MIWC
- Mercurial-insensitive water channel
- WCH4
|
| Gene Name
| AQP4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system |
| GO Classification
|
| Component |
| intrinsic to membrane |
| integral to membrane |
| membrane |
| cell part |
| membrane part |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q11.2-q12.1 |
| SNPs
| AQP4 |
| Gene Sequence
|
>972 bp
ATGAGTGACAGACCCACAGCAAGGCGGTGGGGTAAGTGTGGACCTTTGTGTACCAGAGAG
AACATCATGGTGGCTTTCAAAGGGGTCTGGACTCAAGCTTTCTGGAAAGCAGTCACAGCG
GAATTTCTGGCCATGCTTATTTTTGTTCTCCTCAGCCTGGGATCCACCATCAACTGGGGT
GGAACAGAAAAGCCTTTACCGGTCGACATGGTTCTCATCTCCCTTTGCTTTGGACTCAGC
ATTGCAACCATGGTGCAGTGCTTTGGCCATATCAGCGGTGGCCACATCAACCCTGCAGTG
ACTGTGGCCATGGTGTGCACCAGGAAGATCAGCATCGCCAAGTCTGTCTTCTACATCGCA
GCCCAGTGCCTGGGGGCCATCATTGGAGCAGGAATCCTCTATCTGGTCACACCTCCCAGT
GTGGTGGGAGGCCTGGGAGTCACCATGGTTCATGGAAATCTTACCGCTGGTCATGGTCTC
CTGGTTGAGTTGATAATCACATTTCAATTGGTGTTTACTATCTTTGCCAGCTGTGATTCC
AAACGGACTGATGTCACTGGCTCAATAGCTTTAGCAATTGGATTTTCTGTTGCAATTGGA
CATTTATTTGCAATCAATTATACTGGTGCCAGCATGAATCCCGCCCGATCCTTTGGACCT
GCAGTTATCATGGGAAATTGGGAAAACCATTGGATATATTGGGTTGGGCCCATCATAGGA
GCTGTCCTCGCTGGTGGCCTTTATGAGTATGTCTTCTGTCCAGATGTTGAATTCAAACGT
CGTTTTAAAGAAGCCTTCAGCAAAGCTGCCCAGCAAACAAAAGGAAGCTACATGGAGGTG
GAGGACAACAGGAGTCAGGTAGAGACGGATGACCTGATTCTAAAACCTGGAGTGGTGCAT
GTGATTGACGTTGACCGGGGAGAGGAGAAGAAGGGGAAAGACCAATCTGGAGAGGTATTG
TCTTCAGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 323 |
| Molecular Weight
| 34829.4 |
| Theoretical pI
| 7.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["37-57", "65-85", "116-136", "156-176", "185-205", "232-252"]
|
| Protein Sequence
|
>Aquaporin-4
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
VIDVDRGEEKKGKDQSGEVLSSV
|
| External Links |
|---|
| GenBank ID Protein
| 18490380 |
| UniProtKB/Swiss-Prot ID
| P55087 |
| UniProtKB/Swiss-Prot Entry Name
| AQP4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC022286 |
| GeneCard ID
| AQP4 |
| GenAtlas ID
| AQP4 |
| HGNC ID
| HGNC:637 |
| References |
|---|
| General References
| Not Available |