Showing Protein Uracil nucleotide/cysteinyl leukotriene receptor (CDBP04781)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04781
Secondary Accession Numbers Not Available
Name Uracil nucleotide/cysteinyl leukotriene receptor
Description Not Available
Synonyms
  1. G-protein coupled receptor 17
  2. P2Y-like receptor
  3. R12
  4. UDP/CysLT receptor
Gene Name GPR17
Protein Type Receptor
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
nucleotide receptor activity, g-protein coupled
purinergic nucleotide receptor activity, g-protein coupled
receptor activity
transmembrane receptor activity
molecular transducer activity
signal transducer activity
g-protein coupled receptor activity
Process
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
signaling
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2q21
SNPs GPR17
Gene Sequence 
>1104 bp
ATGTCCAAACGGAGTTGGTGGGCTGGATCCAGAAAGCCCCCAAGAGAGATGCTGAAACTC
TCAGGCTCTGACTCCAGCCAAAGCATGAATGGCCTTGAAGTGGCTCCCCCAGGTCTGATC
ACCAACTTCTCCCTGGCCACGGCAGAGCAATGTGGCCAGGAGACGCCACTGGAGAACATG
CTGTTCGCCTCCTTCTACCTTCTGGATTTTATCCTGGCTTTAGTTGGCAATACCCTGGCT
CTGTGGCTTTTCATCCGAGACCACAAGTCCGGGACCCCGGCCAACGTGTTCCTGATGCAT
CTGGCCGTGGCCGACTTGTCGTGCGTGCTGGTCCTGCCCACCCGCCTGGTCTACCACTTC
TCTGGGAACCACTGGCCATTTGGGGAAATCGCATGCCGTCTCACCGGCTTCCTCTTCTAC
CTCAACATGTACGCCAGCATCTACTTCCTCACCTGCATCAGCGCCGACCGTTTCCTGGCC
ATTGTGCACCCGGTCAAGTCCCTCAAGCTCCGCAGGCCCCTCTACGCACACCTGGCCTGT
GCCTTCCTGTGGGTGGTGGTGGCTGTGGCCATGGCCCCGCTGCTGGTGAGCCCACAGACC
GTGCAGACCAACCACACGGTGGTCTGCCTGCAGCTGTACCGGGAGAAGGCCTCCCACCAT
GCCCTGGTGTCCCTGGCAGTGGCCTTCACCTTCCCGTTCATCACCACGGTCACCTGCTAC
CTGCTGATCATCCGCAGCCTGCGGCAGGGCCTGCGTGTGGAGAAGCGCCTCAAGACCAAG
GCAGTGCGCATGATCGCCATAGTGCTGGCCATCTTCCTGGTCTGCTTCGTGCCCTACCAC
GTCAACCGCTCCGTCTACGTGCTGCACTACCGCAGCCATGGGGCCTCCTGCGCCACCCAG
CGCATCCTGGCCCTGGCAAACCGCATCACCTCCTGCCTCACCAGCCTCAACGGGGCACTC
GACCCCATCATGTATTTCTTCGTGGCTGAGAAGTTCCGCCACGCCCTGTGCAACTTGCTC
TGTGGCAAAAGGCTCAAGGGCCCGCCCCCCAGCTTCGAAGGGAAAACCAACGAGAGCTCG
CTGAGTGCCAAGTCAGAGCTGTGA
Protein Properties
Number of Residues 367
Molecular Weight 40989.0
Theoretical pI 9.82
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["65-85", "93-113", "134-154", "176-196", "224-244", "261-281", "309-329"]
Protein Sequence 
>Uracil nucleotide/cysteinyl leukotriene receptor
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM
LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF
SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC
AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY
LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ
RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS
LSAKSEL
GenBank ID Protein 238814302
UniProtKB/Swiss-Prot ID Q13304
UniProtKB/Swiss-Prot Entry Name GPR17_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001161415.1
GeneCard ID GPR17
GenAtlas ID GPR17
HGNC ID HGNC:4471
References
General References Not Available