Cannabis Compound Database: Showing Protein Antigen peptide transporter 2 (CDBP04770)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04770

Secondary Accession Numbers

Not Available

Name

Antigen peptide transporter 2

Description

Not Available

Synonyms

APT2
ATP-binding cassette sub-family B member 3
PSF-2
Peptide supply factor 2
Peptide transporter PSF2
Peptide transporter TAP2
Peptide transporter involved in antigen processing 2
Really interesting new gene 11 protein

Gene Name

TAP2

Protein Type

Transporter

Biological Properties

General Function

Involved in ATP binding

Specific Function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association

GO Classification

Component
membrane part
intrinsic to membrane
integral to membrane
membrane
cell part
Function
peptide transporter activity
transmembrane transporter activity
atpase activity
active transmembrane transporter activity
transporter activity
primary active transmembrane transporter activity
substrate-specific transporter activity
p-p-bond-hydrolysis-driven transmembrane transporter activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
atpase activity, coupled to transmembrane movement of substances
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
binding
pyrophosphatase activity
nucleotide binding
catalytic activity
hydrolase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Process
peptide transport
establishment of localization
transport
transmembrane transport

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:6

Locus

6p21.3

SNPs

TAP2

Gene Sequence

>4062 bp
ATGCGGCTCCCTGACCTGAGACCCTGGACCTCCCTGCTGCTGGTGGACGCGGCTTTACTG
TGGCTGCTTCAGGGCCCTCTGGGGACTTTGCTTCCTCAAGGGCTGCCAGGACTATGGCTG
GAGGGGACCCTGCGGCTGGGAGGGCTGTGGGGGCTGCTAAAGCTAAGAGGGCTGCTGGGA
TTTGTGGGGACACTGCTGCTCCCGCTCTGTCTGGCCACCCCCCTGACTGTCTCCCTGAGA
GCCCTGGTCGCGGGGGCCTCACGTGCTCCCCCAGCCAGAGTCGCTTCAGCCCCTTGGAGC
TGGCTGCTGGTGGGGTACGGGGCTGCGGGGCTCAGCTGGTCACTGTGGGCTGTTCTGAGC
CCTCCTGGAGCCCAGGAGAAGGAGCAGGACCAGGTGAACAACAAAGTCTTGATGTGGAGG
CTGCTGAAGCTCTCCAGGCCGGACCTGCCTCTCCTCGTTGCCGCCTTCTTCTTCCTTGTC
CTTGCTGTTTTGGGTGAGACATTAATCCCTCACTATTCTGGTCGTGTGATTGACATCCTG
GGAGGTGATTTTGACCCCCATGCCTTTGCCAGTGCCATCTTCTTCATGTGCCTCTTCTCC
TTTGGCAGCTCACTGTCTGCAGGCTGCCGAGGAGGCTGCTTCACCTACACCATGTCTCGA
ATCAACTTGCGGATCCGGGAGCAGCTTTTCTCCTCCCTGCTGCGCCAGGACCTCGGTTTC
TTCCAGGAGACTAAGACAGGGGAGCTGAACTCACGGCTGAGCTCGGATACCACCCTGATG
AGTAACTGGCTTCCTTTAAATGCCAATGTGCTCTTGCGAAGCCTGGTGAAAGTGGTGGGG
CTGTATGGCTTCATGCTCAGCATATCGCCTCGACTCACCCTCCTTTCTCTGCTGCACATG
CCCTTCACAATAGCAGCGGAGAAGGTGTACAACACCCGCCATCAGGAAGTGCTTCGGGAG
ATCCAGGATGCAGTGGCCAGGGCGGGGCAGGTGGTGCGGGAAGCCGTTGGAGGGCTGCAG
ACCGTTCGCAGTTTTGGGGCCGAGGAGCATGAAGTCTGTCGCTATAAAGAGGCCCTTGAA
CAATGTCGGCAGCTGTATTGGCGGAGAGACCTGGAACGCGCCTTGTACCTGCTCATAAGG
AGGGTGCTGCACTTGGGGGTGCAGATGCTGATGCTGAGCTGTGGGCTGCAGCAGATGCAG
GATGGGGAGCTCACCCAGGGCAGCCTGCTTTCCTTTATGATCTACCAGGAGAGCGTGGGG
AGCTATGTGCAGACCCTGGTATACATATATGGGGATATGCTCAGCAACGTGGGAGCTGCA
GAGAAGGTTTTCTCCTACATGGACCGACAGCCAAATCTGCCTTCACCTGGCACGCTTGCC
CCCACCACTCTGCAGGGGGTTGTGAAATTCCAAGACGTCTCCTTTGCATATCCCAATCGC
CCTGACAGGCCTGTGCTCAAGGGGCTGACGTTTACCCTACGTCCTGGTGAGGTGACGGCG
CTGGTGGGACCCAATGGGTCTGGGAAGAGCACAGTGGCTGCCCTGCTGCAGAATCTGTAC
CAGCCCACAGGGGGACAGGTGCTGCTGGATGAAAAGCCCATCTCACAGTATGAACACTGC
TACCTGCACAGCCAGGTGGTTTCAGTTGGGCAGGAGCCTGTGCTGTTCTCCGGTTCTGTG
AGGAACAACATTACTTATGGGCTGCAGAGCTGCGAAGATGATAAGGTGATGGCGGCTGCC
CAGGCTGCCCACGCAGATGACTTCATCCAGGAAATGGAGCATGGAATATACACAGATGTA
GGGGAGAAGGGAAGCCAGCTGGCTGCGGGACAGAAACAACGTCTGGCCATTGCCCGGGCC
CTTGTACGAGACCCGCGGGTCCTCATCCTGGATGAGGCTACTAGTGCCCTAGATGTGCAG
TGCGAGCAGGCCCTGCAGGACTGGAATTCCCGTGGGGATCGCACAGTGCTGGTGATTGCT
CACAGGCTGCAGACAGTTCAGCGCGCCCACCAGATCCTGGTGCTCCAGGAGGGCAAGCTG
CAGAAGCTTGCCCAGCTCTAG

Protein Properties

Number of Residues

686

Molecular Weight

75663.2

Theoretical pI

8.1

Pfam Domain Function

ABC_tran (PF00005 )
ABC_membrane (PF00664 )

Signals

["None"]

Transmembrane Regions

["7-27", "57-77", "99-119", "149-169", "188-208", "267-287", "294-314", "375-395", "409-429"]

Protein Sequence

>Antigen peptide transporter 2
MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG
FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS
PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL
GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF
FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM
PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE
QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG
SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR
PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC
YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV
GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIA
HRLQTVQRAHQILVLQEGKLQKLAQL

External Links

GenBank ID Protein

168983733

UniProtKB/Swiss-Prot ID

Q03519

UniProtKB/Swiss-Prot Entry Name

TAP2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

CT009502

GeneCard ID