Cannabis Compound Database: Showing Protein Antigen peptide transporter 1 (CDBP04769)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04769

Secondary Accession Numbers

Not Available

Name

Antigen peptide transporter 1

Description

Not Available

Synonyms

APT1
ATP-binding cassette sub-family B member 2
PSF-1
Peptide supply factor 1
Peptide transporter PSF1
Peptide transporter TAP1
Peptide transporter involved in antigen processing 1
Really interesting new gene 4 protein

Gene Name

TAP1

Protein Type

Transporter

Biological Properties

General Function

Involved in ATP binding

Specific Function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules

GO Classification

Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
peptide transporter activity
transmembrane transporter activity
atpase activity
active transmembrane transporter activity
transporter activity
primary active transmembrane transporter activity
substrate-specific transporter activity
p-p-bond-hydrolysis-driven transmembrane transporter activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
atpase activity, coupled to transmembrane movement of substances
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
binding
pyrophosphatase activity
nucleotide binding
catalytic activity
hydrolase activity
nucleoside binding
purine nucleoside binding
Process
peptide transport
establishment of localization
transport
transmembrane transport

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:6

Locus

6p21.3

SNPs

TAP1

Gene Sequence

>2427 bp
ATGGCTGAGCTTCTCGCCAGCGCAGGATCAGCCTGTTCCTGGGACTTTCCGAGAGCCCCG
CCCTCGTTCCCTCCCCCAGCCGCCAGTAGGGGAGGACTCGGCGGTACCCGGAGCTTCAGG
CCCCACCGGGGCGCGGAGAGTCCCAGACCCGGCCGGGACCGGGACGGCGTCCGAGTGCCA
ATGGCTAGCTCTAGGTGTCCCGCTCCCCGCGGGTGCCGCTGCCTCCCCGGAGCTTCTCTC
GCATGGCTGGGGACAGTACTGCTACTTCTCGCCGACTGGGTGCTGCTCCGGACCGCGCTG
CCCCGCATATTCTCCCTGCTGGTGCCCACCGCGCTGCCACTGCTCCGGGTCTGGGCGGTG
GGCCTGAGCCGCTGGGCCGTGCTCTGGCTGGGGGCCTGCGGGGTCCTCAGGGCAACGGTT
GGCTCCAAGAGCGAAAACGCAGGTGCCCAGGGCTGGCTGGCTGCTTTGAAGCCATTAGCT
GCGGCACTGGGCTTGGCCCTGCCGGGACTTGCCTTGTTCCGAGAGCTGATCTCATGGGGA
GCCCCCGGGTCCGCGGATAGCACCAGGCTACTGCACTGGGGAAGTCACCCTACCGCCTTC
GTTGTCAGTTATGCAGCGGCACTGCCCGCAGCAGCCCTGTGGCACAAACTCGGGAGCCTC
TGGGTGCCCGGCGGTCAGGGCGGCTCTGGAAACCCTGTGCGTCGGCTTCTAGGCTGCCTG
GGCTCGGAGACGCGCCGCCTCTCGCTGTTCCTGGTCCTGGTGGTCCTCTCCTCTCTTGGG
GAGATGGCCATTCCATTCTTTACGGGCCGCCTCACTGACTGGATTCTACAAGATGGCTCA
GCCGATACCTTCACTCGAAACTTAACTCTCATGTCCATTCTCACCATAGCCAGTGCAGTG
CTGGAGTTCGTGGGTGACGGGATCTATAACAACACCATGGGCCACGTGCACAGCCACTTG
CAGGGAGAGGTGTTTGGGGCTGTCCTGCGCCAGGAGACGGAGTTTTTCCAACAGAACCAG
ACAGGTAACATCATGTCTCGGGTAACAGAGGACACGTCCACCCTGAGTGATTCTCTGAGT
GAGAATCTGAGCTTATTTCTGTGGTACCTGGTGCGAGGCCTATGTCTCTTGGGGATCATG
CTCTGGGGATCAGTGTCCCTCACCATGGTCACCCTGATCACCCTGCCTCTGCTTTTCCTT
CTGCCCAAGAAGGTGGGAAAATGGTACCAGTTGCTGGAAGTGCAGGTGCGGGAATCTCTG
GCAAAGTCCAGCCAGGTGGCCATTGAGGCTCTGTCGGCCATGCCTACAGTTCGAAGCTTT
GCCAACGAGGAGGGCGAAGCCCAGAAGTTTAGGGAAAAGCTGCAAGAAATAAAGACACTC
AACCAGAAGGAGGCTGTGGCCTATGCAGTCAACTCCTGGACCACTAGTATTTCAGGTATG
CTGCTGAAAGTGGGAATCCTCTACATTGGTGGGCAGCTGGTGACCAGTGGGGCTGTAAGC
AGTGGGAACCTTGTCACATTTGTTCTCTACCAGATGCAGTTCACCCAGGCTGTGGAGGTA
CTGCTCTCCATCTACCCCAGAGTACAGAAGGCTGTGGGCTCCTCAGAGAAAATATTTGAG
TACCTGGACCGCACCCCTCGCTGCCCACCCAGTGGTCTGTTGACTCCCTTACACTTGGAG
GGCCTTGTCCAGTTCCAAGATGTCTCCTTTGCCTACCCAAACCGCCCAGATGTCTTAGTG
CTACAGGGGCTGACATTCACCCTACGCCCTGGCGAGGTGACGGCGCTGGTGGGACCCAAT
GGGTCTGGGAAGAGCACAGTGGCTGCCCTGCTGCAGAATCTGTACCAGCCCACCGGGGGA
CAGCTGCTGTTGGATGGGAAGCCCCTTCCCCAATATGAGCACCGCTACCTGCACAGGCAG
GTGGCTGCAGTGGGACAAGAGCCACAGGTATTTGGAAGAAGTCTTCAAGAAAATATTGCC
TATGGCCTGACCCAGAAGCCAACTATGGAGGAAATCACAGCTGCTGCAGTAAAGTCTGGG
GCCCATAGTTTCATCTCTGGACTCCCTCAGGGCTATGACACAGAGGTAGACGAGGCTGGG
AGCCAGCTGTCAGGGGGTCAGCGACAGGCAGTGGCGTTGGCCCGAGCATTGATCCGGAAA
CCGTGTGTACTTATCCTGGATGATGCCACCAGTGCCCTGGATGCAAACAGCCAGTTACAG
GTGGAGCAGCTCCTGTACGAAAGCCCTGAGCGGTACTCCCGCTCAGTGCTTCTCATCACC
CAGCACCTCAGCCTGGTGGAGCAGGCTGACCACATCCTCTTTCTGGAAGGAGGCGCTATC
CGGGAGGGGGGAACCCACCAGCAGCTCATGGAGAAAAAGGGGTGCTACTGGGCCATGGTG
CAGGCTCCTGCAGATGCTCCAGAATGA

Protein Properties

Number of Residues

808

Molecular Weight

87216.9

Theoretical pI

8.11

Pfam Domain Function

ABC_tran (PF00005 )
ABC_membrane (PF00664 )

Signals

["None"]

Transmembrane Regions

["76-96", "114-136", "153-173", "194-214", "247-267", "288-308", "359-379", "389-409", "479-499", "504-524"]

Protein Sequence

>Antigen peptide transporter 1
MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVP
MASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAV
GLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWG
APGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCL
GSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAV
LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS
ENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL
AKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGM
LLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFE
YLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPN
GSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIA
YGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRK
PCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAI
REGGTHQQLMEKKGCYWAMVQAPADAPE

External Links

GenBank ID Protein

36061

UniProtKB/Swiss-Prot ID

Q03518

UniProtKB/Swiss-Prot Entry Name

TAP1_HUMAN

PDB IDs