| Identification |
|---|
| HMDB Protein ID
| CDBP04761 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nucleolar and coiled-body phosphoprotein 1 |
| Description
| Not Available |
| Synonyms
|
- 140 kDa nucleolar phosphoprotein
- HCV NS5A-transactivated protein 13
- Hepatitis C virus NS5A-transactivated protein 13
- Nopp140
- Nucleolar 130 kDa protein
- Nucleolar phosphoprotein p130
|
| Gene Name
| NOLC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q24.32 |
| SNPs
| NOLC1 |
| Gene Sequence
|
>2100 bp
ATGGCGGACGCCGGCATTCGCCGCGTGGTTCCCAGCGACCTGTATCCCCTCGTGCTCGGC
TTCCTGCGCGATAACCAACTCTCAGAGGTGGCCAATAAGTTCGCCAAAGCGACAGGAGCT
ACACAGCAGGATGCCAATGCCTCTTCCCTCTTAGACATCTATAGCTTCTGGCTCAAGTCT
GCCAAGGTCCCAGAGCGAAAGTTACAGGCAAATGGACCAGTGGCTAAGAAAGCTAAGAAG
AAGGCCTCATCCAGTGACAGTGAGGACAGCAGCGAGGAGGAGGAGGAAGTTCAAGGGCCT
CCAGCAAAGAAGGCTGCTGTACCTGCCAAGCGAGTCGGTCTGCCTCCTGGGAAGGCTGCA
GCCAAAGCATCAGAGAGTAGCAGCAGTGAAGAGTCCAGTGATGATGATGATGAGGAGGAC
CAAAAGAAACAGCCTGTCCAGAAGGGAGTTAAGCCCCAAGCCAAGGCAGCCAAAGCTCCT
CCTAAGAAGGCCAAGAGCTCTGATTCTGATTCTGACTCAAGCTCCGAGGATGAGCCACCA
AAGAACCAGAAGCCAAAGATAACACCTGTGACAGTTAAAGCTCAGACTAAAGCCCCTCCC
AAACCAGCTCGAGCAGCACCTAAAATAGCCAATGGTAAAGCAGCCAGTAGCAGCAGTAGC
AGCAGCAGCAGCAGTAGCAGTGATGACTCAGAGGAGGAGAAGGCAGCAGCCACCCCCAAG
AAGACTGTACCTAAAAAGCAAGTTGTGGCCAAGGCCCCAGTGAAAGCAGCTACCACCCCT
ACCCGGAAGAGTTCTAGCAGTGAGGATTCCTCCAGTGACGAGGAAGAGGAGCAAAAAAAA
CCCATGAAAAATAAACCAGGTCCCTACAGTTCAGTCCCCCCGCCTTCTGCTCCCCCACCA
AAGAAGTCTCTGGGAACCCAGCCTCCCAAGAAGGCTGTGGAGAAGCAGCAGCCTGTGGAA
AGCAGTGAAGACAGCAGTGATGAGTCTGATTCAAGTTCTGAAGAAGAGAAGAAACCCCCA
ACTAAGGCAGTAGTCTCTAAAGCAACCACTAAACCACCTCCAGCAAAGAAAGCAGCAGAG
AGCTCTTCAGACAGCTCAGACTCTGACAGCTCTGAGGATGATGAAGCTCCTTCTAAGCCA
GCTGGTACCACCAAGAATTCTTCAAATAAGCCAGCTGTCACCACCAAGTCACCTGCAGTG
AAGCCAGCTGCAGCCCCCAAGCAACCTGTGGGCGGTGGCCAGAAGCTTCTGACGAGAAAG
GCTGACAGCAGCTCCAGTGAGGAAGAGAGCAGCTCCAGTGAGGAGGAGAAGACAAAGAAG
ATGGTGGCCACCACTAAGCCCAAGGCGACTGCCAAAGCAGCTCTATCTCTGCCTGCCAAG
CAGGCTCCTCAGGGTAGTAGGGACAGCAGCTCTGATTCAGACAGCTCCAGCAGTGAGGAG
GAGGAAGAGAAGACATCTAAGTCTGCAGTTAAGAAGAAGCCACAGAAGGTAGCAGGAGGT
GCAGCCCCTTCCAAGCCAGCCTCTGCAAAGAAAGGAAAGGCTGAGAGCAGCAACAGTTCT
TCTTCTGATGACTCCAGTGAGGAAGAGGAAGAGAAGCTCAAGGGCAAGGGCTCTCCAAGA
CCACAAGCCCCCAAGGCCAATGGCACCTCTGCACTGACTGCCCAGAATGGAAAAGCAGCT
AAGAACAGTGAGGAGGAGGAAGAAGAAAAGAAAAAGGCGGCAGTGGTAGTTTCCAAATCA
GGTTCATTAAAGAAGCGGAAGCAGAATGAGGCTGCCAAGGAGGCAGAGACTCCTCAGGCC
AAGAAGATAAAGCTTCAGACCCCTAACACATTTCCAAAAAGGAAGAAAGGAGAAAAAAGG
GCATCATCCCCATTCCGAAGGGTCAGGGAGGAGGAAATTGAGGTGGATTCACGAGTTGCG
GACAACTCCTTTGATGCCAAGCGAGGTGCAGCCGGAGACTGGGGAGAGCGAGCCAATCAG
GTTTTGAAGTTCACCAAAGGCAAGTCCTTTCGGCATGAGAAAACCAAGAAGAAGCGGGGC
AGCTACCGGGGAGGCTCAATCTCTGTCCAGGTCAATTCTATTAAGTTTGACAGCGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 699 |
| Molecular Weight
| 73602.5 |
| Theoretical pI
| 10.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nucleolar and coiled-body phosphoprotein 1
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS
AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA
AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP
KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK
KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP
KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE
SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK
ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE
EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR
PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA
KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ
VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE
|
| External Links |
|---|
| GenBank ID Protein
| 55665422 |
| UniProtKB/Swiss-Prot ID
| Q14978 |
| UniProtKB/Swiss-Prot Entry Name
| NOLC1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL500527 |
| GeneCard ID
| NOLC1 |
| GenAtlas ID
| NOLC1 |
| HGNC ID
| HGNC:15608 |
| References |
|---|
| General References
| Not Available |