| Identification |
|---|
| HMDB Protein ID
| CDBP04755 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transcription factor MafF |
| Description
| Not Available |
| Synonyms
|
- U-Maf
- V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
|
| Gene Name
| MAFF |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| biological regulation |
| regulation of biological process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q13.1 |
| SNPs
| MAFF |
| Gene Sequence
|
>495 bp
ATGTCTGTGGATCCCCTATCCAGCAAAGCTCTAAAGATCAAGCGAGAGCTGAGCGAGAAC
ACGCCGCACCTGTCGGACGAGGCGCTGATGGGGCTGTCGGTGCGCGAGCTGAACCGGCAT
CTGCGCGGGCTCTCCGCCGAGGAGGTGACACGGCTCAAGCAGCGGCGCCGCACACTCAAA
AACCGTGGCTACGCCGCCAGCTGCCGCGTGAAGCGCGTGTGCCAGAAGGAGGAGCTGCAG
AAGCAGAAGTCGGAGCTGGAGCGCGAGGTGGACAAGCTGGCGCGCGAGAACGCCGCCATG
CGCCTGGAGCTCGACGCGCTGCGCGGCAAGTGCGAGGCGCTGCAGGCGTTCGCGCGCTCC
GTGGCCGCCGCCCGCGGGCCCGCCACGCTCGTGGCGCCGGCCAGCGTCATCACCATCGTC
AAGTCCACCCCGGGCTCGGGGTCTGGCCCCGCCCACGGCCCGGACCCCGCCCACGGCCCG
GCCTCCTGCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 164 |
| Molecular Weight
| 17760.2 |
| Theoretical pI
| 10.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transcription factor MafF
MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLK
NRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARS
VAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS
|
| External Links |
|---|
| GenBank ID Protein
| 6429134 |
| UniProtKB/Swiss-Prot ID
| Q9ULX9 |
| UniProtKB/Swiss-Prot Entry Name
| MAFF_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB025247 |
| GeneCard ID
| MAFF |
| GenAtlas ID
| MAFF |
| HGNC ID
| HGNC:6780 |
| References |
|---|
| General References
| Not Available |