Cannabis Compound Database: Showing Protein Sodium bicarbonate transporter-like protein 11 (CDBP04754)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP04754

Secondary Accession Numbers

Not Available

Name

Sodium bicarbonate transporter-like protein 11

Description

Not Available

Synonyms

Bicarbonate transporter-related protein 1
NaBC1
Sodium borate cotransporter 1
Solute carrier family 4 member 11

Gene Name

SLC4A11

Protein Type

Transporter

Biological Properties

General Function

Involved in anion transport

Specific Function

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.

GO Classification

Biological Process
cellular cation homeostasis
fluid transport
phosphoenolpyruvate-dependent sugar phosphotransferase system
Cellular Component
basolateral plasma membrane
integral to membrane
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
cation transmembrane transporter activity
anion:anion antiporter activity
solute:cation symporter activity
cation:sugar symporter activity
sugar:hydrogen symporter activity
transporter activity
anion transmembrane transporter activity
inorganic anion exchanger activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
Molecular Function
bicarbonate transmembrane transporter activity
borate transmembrane transporter activity
sugar:hydrogen symporter activity
hydrogen ion channel activity
inorganic anion exchanger activity
sodium channel activity
protein dimerization activity
Process
transport
carbohydrate transport
anion transport
ion transport
phosphoenolpyruvate-dependent sugar phosphotransferase system
establishment of localization

Cellular Location

Cell membrane
Membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

20p12

SNPs

SLC4A11

Gene Sequence

>2676 bp
ATGAGCCAGGTCGGGGGGCGGGGAGACAGGTGCACACAGGAGGTCCAGGGCTTGGTCCAT
GGGGCTGGTGACCTTTCTGCTTCCCTTGCAGAAAACTCTCCCACCATGTCGCAGAATGGA
TACTTCGAGGATTCAAGCTACTACAAGTGTGACACAGATGACACCTTCGAAGCCCGAGAG
GAGATCCTGGGGGATGAGGCCTTCGACACTGCCAACTCCTCCATCGTGTCTGGCGAGAGT
ATCCGTTTTTTTGTCAATGTCAACCTTGAGATGCAGGCCACCAACACTGAGAATGAAGCG
ACTTCCGGTGGCTGTGTGCTCCTGCACACCTCCCGAAAGTACCTGAAGTTAAAGAACTTC
AAGGAAGAGATCCGTGCGCACCGCGACCTAGATGGCTTCCTGGCGCAGGCCAGCATCGTC
CTGAACGAGACGGCCACCTCCCTGGATAACGTGCTGCGGACCATGCTTCGCCGCTTCGCC
AGGGACCCTGACAACAATGAGCCCAACTGCAACCTGGACCTGCTCATGGCCATGCTCTTC
ACCGATGCCGGGGCACCCATGCGGGGTAAAGTCCACCTGCTGTCAGATACCATCCAAGGG
GTCACCGCCACAGTGACAGGGGTGCGGTACCAGCAGTCGTGGCTCTGCATCATCTGTACC
ATGAAGGCCCTACAGAAGCGGCACGTGTGCATCAGCCGCCTGGTTCGCCCACAGAACTGG
GGGGAGAATTCCTGTGAGGTTCGGTTCGTCATCCTGGTGCTGGCCCCACCCAAGATGAAA
AGCACTAAGACTGCGATGGAGGTGGCGCGCACGTTTGCCACCATGTTCTCGGATATCGCC
TTCCGCCAGAAGCTCCTGGAGACCCGCACAGAGGAGGAATTCAAGGAGGCCTTGGTGCAT
CAGAGACAGCTGCTCACCATGGTGAGCCACGGTCCAGTGGCGCCGAGAACGAAGGAACGC
AGCACAGTCTCCCTCCCTGCCCACAGACACCCAGAGCCCCCAAAGTGCAAGGACTTTGTC
CCTTTTGGGAAGGGCATCCGGGAGGACATCGCACGCAGGTTCCCCTTGTACCCCTTGGAC
TTCACTGATGGCATTATTGGGAAAAACAAGGCTGTGGGCAAATACATCACCACCACCCTG
TTCCTCTACTTCGCCTGCCTCCTGCCCACCATCGCTTTCGGGTCTCTCAATGACGAGAAC
ACAGACGGGGCCATCGACGTGCAGAAGACCATAGCCGGGCAGAGCATCGGGGGCCTGCTC
TACGCGCTCTTCTCTGGGCAGCCATTGGTGATTCTGCTGACCACCGCGCCCCTGGCGCTC
TACATCCAGGTGATTCGTGTCATCTGTGATGACTATGACCTGGACTTCAACTCCTTCTAC
GCATGGACGGGCCTGTGGAATAGTTTCTTCCTTGCGCTTTATGCCTTTTTCAACCTCAGC
CTGGTCATGAGTCTCTTCAAGAGGTCGACGGAGGAGATCATCGCCCTCTTCATTTCCATC
ACGTTTGTGCTGGATGCCGTCAAGGGCACGGTTAAAATCTTCTGGAAGTACTACTATGGG
CATTACTTGGACGACTATCACACAAAAAGGACTTCATCCCTTGTCAGCCTGTCAGGCCTC
GGCGCCAGCCTCAACGCCAGCCTCCACACTGCCCTCAACGCCAGCTTCCTCGCCAGCCCC
ACGGAGCTGCCCTCGGCCACACACTCAGGCCAGGCGACCGCCGTGCTCAGCCTCCTCATC
ATGCTGGGCACGCTCTGGCTGGGCTACACCCTCTACCAATTCAAGAAGAGCCCCTACCTG
CACCCCTGCGTGCGAGAGATCCTGTCCGACTGCGCCCTGCCCATCGCGGTGCTCGCCTTC
TCCCTCATCAGCTCCCATGGCTTCCGGGAAATCGAGATGAGCAAGTTCCGCTACAACCCC
AGCGAGAGCCCCTTTGCGATGGCGCAGATCCAGTCGCTGTCCCTGAGGGCCGTCAGCGGT
GCCATGGGCCTCGGCTTCCTGCTGTCCATGCTCTTCTTCATCGAGCAGAACTTGGTGGCC
GCCTTGGTGAATGCACCGGAGAACAGGCTGGTGAAGGGCACTGCCTACCACTGGGACCTC
CTGCTCCTCGCCATCATCAACACAGGGCTGTCTCTGTTTGGGCTGCCTTGGATCCATGCC
GCCTACCCCCACTCCCCGCTGCACGTGCGAGCCCTGGCCTTAGTGGAGGAGCGTGTGGAG
AACGGACACATCTATGACACGATTGTGAACGTGAAGGAGACGCGGCTGACCTCGCTGGGC
GCCAGCGTCCTGGTGGGCCTGTCCCTGTTGCTGCTGCCGGTCCCGCTTCAGTGGATCCCC
AAGCCCGTGCTCTATGGCCTCTTCCTCTACATCGCGCTCACCTCCCTCGATGGCAACCAG
CTCGTCCAGCGCGTGGCCCTGCTGCTCAAGGAGCAGACTGCGTACCCCCCGACACACTAC
ATCCGGAGGGTGCCCCAGAGGAAGATCCACTACTTCACGGGCCTGCAGGTGCTTCAGCTG
CTGCTGCTGTGTGCCTTCGGCATGAGCTCCCTGCCCTACATGAAGATGATCTTTCCCCTC
ATCATGATCGCCATGATCCCCATCCGCTATATCCTGCTGCCCCGAATCATTGAAGCCAAG
TACTTGGATGTCATGGACGCTGAGCACAGGCCTTGA

Protein Properties

Number of Residues

891

Molecular Weight

98180.24

Theoretical pI

8.018

Pfam Domain Function

HCO3_cotransp (PF00955 )
PTS_EIIA_2 (PF00359 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Sodium bicarbonate transporter-like protein 11
MSQVGGRGDRCTQEVQGLVHGAGDLSASLAENSPTMSQNGYFEDSSYYKCDTDDTFEARE
EILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATSGGCVLLHTSRKYLKLKNF
KEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFARDPDNNEPNCNLDLLMAMLF
TDAGAPMRGKVHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNW
GENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVH
QRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIREDIARRFPLYPLD
FTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLL
YALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLS
LVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGL
GASLNASLHTALNASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYL
HPCVREILSDCALPIAVLAFSLISSHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSG
AMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHA
AYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIP
KPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQL
LLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP

External Links

GenBank ID Protein

13249297

UniProtKB/Swiss-Prot ID

Q8NBS3

UniProtKB/Swiss-Prot Entry Name

S4A11_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF336127

GeneCard ID