| Identification |
|---|
| HMDB Protein ID
| CDBP04730 |
| Secondary Accession Numbers
| Not Available |
| Name
| Selenoprotein S |
| Description
| Not Available |
| Synonyms
|
- SelS
- VCP-interacting membrane protein
|
| Gene Name
| SELS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in selenium binding |
| Specific Function
| Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| intrinsic to organelle membrane |
| intrinsic to endoplasmic reticulum membrane |
| integral to endoplasmic reticulum membrane |
| Function |
| binding |
| selenium binding |
| Process |
| transport |
| protein transport |
| intracellular protein transport |
| establishment of localization |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q26.3 |
| SNPs
| SELS |
| Gene Sequence
|
>570 bp
ATGGAACGCCAAGAGGAGTCTCTGTCCGCGCGGCCGGCCCTGGAGACCGAGGGGCTGCGC
TTCCTGCACACCACGGTGGGCTCCCTGCTGGCCACCTATGGCTGGTACATCGTCTTCAGC
TGCATCCTTCTCTACGTGGTCTTTCAGAAGCTTTCCGCCCGGCTAAGAGCCTTGAGGCAG
AGGCAGCTGGACCGAGCTGCGGCTGCTGTGGAACCTGATGTTGTTGTTAAACGACAAGAA
GCTTTAGCAGCTGCTCGACTGAAAATGCAAGAAGAACTAAATGCGCAAGTTGAAAAGCAT
AAGGAAAAACTGAAACAACTTGAAGAAGAAAAAAGGAGACAGAAGATTGAAATGTGGGAC
AGCATGCAAGAAGGAAAAAGTTACAAAGGAAATGCAAAGAAGCCCCAGGAGGAAGACAGT
CCTGGGCCTTCCACTTCATCTGTCCTGAAACGGAAATCGGACAGAAAGCCTTTGCGGGGA
GGAGGTTATAACCCGTTGTCTGGTGAAGGAGGCGGAGCTTGCTCCTGGAGACCTGGACGC
AGAGGCCCGTCATCTGGCGGATGAGGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 189 |
| Molecular Weight
| 21162.8 |
| Theoretical pI
| 10.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Selenoprotein S
MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQ
RQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWD
SMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRGGGYNPLSGEGGGACSWRPGR
RGPSSGGUG
|
| External Links |
|---|
| GenBank ID Protein
| 33285002 |
| UniProtKB/Swiss-Prot ID
| Q9BQE4 |
| UniProtKB/Swiss-Prot Entry Name
| SELS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018445.4 |
| GeneCard ID
| SELS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |