| Identification |
|---|
| HMDB Protein ID
| CDBP04718 |
| Secondary Accession Numbers
| Not Available |
| Name
| Kallikrein-6 |
| Description
| Not Available |
| Synonyms
|
- Neurosin
- Protease M
- SP59
- Serine protease 18
- Serine protease 9
- Zyme
|
| Gene Name
| KLK6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serine-type endopeptidase activity |
| Specific Function
| Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis |
| GO Classification
|
| Function |
| endopeptidase activity |
| serine-type endopeptidase activity |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Mitochondrion
- nucleolus
- Secreted
- Microsome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.3 |
| SNPs
| KLK6 |
| Gene Sequence
|
>735 bp
ATGAAGAAGCTGATGGTGGTGCTGAGTCTGATTGCTGCAGCCTGGGCAGAGGAGCAGAAT
AAGTTGGTGCATGGCGGACCCTGCGACAAGACATCTCACCCCTACCAAGCTGCCCTCTAC
ACCTCGGGCCACTTGCTCTGTGGTGGGGTCCTTATCCATCCACTGTGGGTCCTCACAGCT
GCCCACTGCAAAAAACCGAATCTTCAGGTCTTCCTGGGGAAGCATAACCTTCGGCAAAGG
GAGAGTTCCCAGGAGCAGAGTTCTGTTGTCCGGGCTGTGATCCACCCTGACTATGATGCC
GCCAGCCATGACCAGGACATCATGCTGTTGCGCCTGGCACGCCCAGCCAAACTCTCTGAA
CTCATCCAGCCCCTTCCCCTGGAGAGGGACTGCTCAGCCAACACCACCAGCTGCCACATC
CTGGGCTGGGGCAAGACAGCAGATGGTGATTTCCCTGACACCATCCAGTGTGCATACATC
CACCTGGTGTCCCGTGAGGAGTGTGAGCATGCCTACCCTGGCCAGATCACCCAGAACATG
TTGTGTGCTGGGGATGAGAAGTACGGGAAGGATTCCTGCCAGGGTGATTCTGGGGGTCCG
CTGGTATGTGGAGACCACCTCCGAGGCCTTGTGTCATGGGGTAACATCCCCTGTGGATCA
AAGGAGAAGCCAGGAGTCTACACCAACGTCTGCAGATACACGAACTGGATCCAAAAAACC
ATTCAGGCCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 26855.5 |
| Theoretical pI
| 7.48 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Kallikrein-6
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTA
AHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSE
LIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNM
LCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKT
IQAK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q92876 |
| UniProtKB/Swiss-Prot Entry Name
| KLK6_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U62801 |
| GeneCard ID
| KLK6 |
| GenAtlas ID
| KLK6 |
| HGNC ID
| HGNC:6367 |
| References |
|---|
| General References
| Not Available |