Showing Protein Dynein light chain 1, cytoplasmic (CDBP04700)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP04700
Secondary Accession Numbers Not Available
Name Dynein light chain 1, cytoplasmic
Description Not Available
Synonyms
  1. 8 kDa dynein light chain
  2. DLC8
  3. Dynein light chain LC8-type 1
  4. PIN
  5. Protein inhibitor of neuronal nitric oxide synthase
Gene Name DYNLL1
Protein Type Enzyme
Biological Properties
General Function Involved in microtubule-based process
Specific Function Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity
GO Classification
Component
protein complex
microtubule associated complex
macromolecular complex
Process
cellular process
microtubule-based process
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Mitochondrion
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.23
SNPs DYNLL1
Gene Sequence 
>267 bp
ATGTGCGACCGAAAGGCCGTGATCAAAAATGCGGACATGTCGGAAGAGATGCAACAGGAC
TCGGTGGAGTGCGCTACTCAGGCGCTGGAGAAATACAACATAGAGAAGGACATTGCGGCT
CATATCAAGAAGGAATTTGACAAGAAGTACAATCCCACCTGGCATTGCATCGTGGGGAGG
AACTTCGGTAGTTATGTGACACATGAAACCAAACACTTCATCTACTTCTACCTGGGCCAA
GTGGCCATTCTTCTGTTCAAATCTGGT
Protein Properties
Number of Residues 89
Molecular Weight 10365.8
Theoretical pI 7.5
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Dynein light chain 1, cytoplasmic
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
GenBank ID Protein 47115281
UniProtKB/Swiss-Prot ID P63167
UniProtKB/Swiss-Prot Entry Name DYL1_HUMAN
PDB IDs
GenBank Gene ID CR407672
GeneCard ID DYNLL1
GenAtlas ID DYNLL1
HGNC ID HGNC:15476
References
General References Not Available