| Identification |
|---|
| HMDB Protein ID
| CDBP04694 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase 1 regulatory subunit 3B |
| Description
| Not Available |
| Synonyms
|
- Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
- PP1 subunit R4
- Protein phosphatase 1 regulatory subunit 4
- Protein phosphatase 1 subunit GL
|
| Gene Name
| PPP1R3B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glycogen metabolic process |
| Specific Function
| Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p23.1 |
| SNPs
| PPP1R3B |
| Gene Sequence
|
>858 bp
ATGATGGCTGTGGACATCGAGTACAGATACAACTGCATGGCTCCTTCCTTGCGCCAAGAG
AGGTTTGCCTTTAAGATCTCACCAAAGCCCAGCAAACCACTGAGGCCTTGTATTCAGCTG
AGCAGCAAGAATGAAGCCAGTGGAATGGTGGCCCCGGCTGTCCAGGAGAAGAAGGTGAAA
AAGCGGGTGTCCTTCGCAGACAACCAGGGGCTGGCCCTGACAATGGTCAAAGTGTTCTCG
GAATTCGATGACCCGCTAGATATGCCATTCAACATCACCGAGCTCCTAGACAACATTGTG
AGCTTGACGACAGCAGAGAGCGAGAGCTTTGTTCTGGATTTTTCCCAGCCCTCTGCAGAT
TACTTAGACTTTAGAAATCGACTTCAGGCCGACCACGTCTGCCTTGAGAACTGTGTGCTC
AAGGACAAGGCCATTGCAGGCACTGCGAAGGTTCAGAACCTCGCATTTGAGAAGACCGTG
AAAATAAGGATGACGTTCGACACCTGGAAGAGCTACACAGACTTTCCTTGTCAGTACGTG
AAGGACACTTATGCCGGTTCAGACAGGGACACGTTCTCCTTCGACATCAGTTTGCCCGAG
AAGATTCAGTCTTATGAAAGAATGGAGTTTGCTGTGTACTACGAGTGCAATGGACAGACG
TACTGGGACAGCAACAGAGGCAAGAACTATAGGATCATCCGGGCTGAGTTAAAATCTACC
CAGGGAATGACCAAGCCCCACAGTGGACCGGATTTGGGAATATCCTTTGACCAGTTCGGA
AGCCCTCGGTGTTCCTATGGTCTGTTTCCAGAGTGGCCAAGTTACTTAGGATATGAAAAG
CTAGGGCCCTACTACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 285 |
| Molecular Weight
| 32694.9 |
| Theoretical pI
| 5.92 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein phosphatase 1 regulatory subunit 3B
MMAVDIEYRYNCMAPSLRQERFAFKISPKPSKPLRPCIQLSSKNEASGMVAPAVQEKKVK
KRVSFADNQGLALTMVKVFSEFDDPLDMPFNITELLDNIVSLTTAESESFVLDFSQPSAD
YLDFRNRLQADHVCLENCVLKDKAIAGTVKVQNLAFEKTVKIRMTFDTWKSYTDFPCQYV
KDTYAGSDRDTFSFDISLPEKIQSYERMEFAVYYECNGQTYWDSNRGKNYRIIRAELKST
QGMTKPHSGPDLGISFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY
|
| External Links |
|---|
| GenBank ID Protein
| 10436349 |
| UniProtKB/Swiss-Prot ID
| Q86XI6 |
| UniProtKB/Swiss-Prot Entry Name
| PPR3B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK024067 |
| GeneCard ID
| PPP1R3B |
| GenAtlas ID
| PPP1R3B |
| HGNC ID
| HGNC:14942 |
| References |
|---|
| General References
| Not Available |