| Identification |
|---|
| HMDB Protein ID
| CDBP04689 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prostaglandin E synthase 3 |
| Description
| Not Available |
| Synonyms
|
- Cytosolic prostaglandin E2 synthase
- Hsp90 co-chaperone
- Progesterone receptor complex p23
- Telomerase-binding protein p23
- cPGES
|
| Gene Name
| PTGES3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in prostaglandin-E synthase activity |
| Specific Function
| Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.
|
| GO Classification
|
| Biological Process |
| signal transduction |
| telomere maintenance |
| chaperone cofactor-dependent protein refolding |
| prostaglandin biosynthetic process |
| Cellular Component |
| cytosol |
| chromosome, telomeric region |
| telomerase holoenzyme complex |
| Molecular Function |
| prostaglandin-E synthase activity |
| unfolded protein binding |
| telomerase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | prostaglandin biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12 |
| SNPs
| PTGES3 |
| Gene Sequence
|
>483 bp
ATGCAGCCTGCTTCTGCAAAGTGGTACGATCGAAGGGACTATGTCTTCATTGAATTTTGT
GTTGAAGACAGTAAGGATGTTAATGTAAATTTTGAAAAATCCAAACTTACATTCAGTTGT
CTCGGAGGAAGTGATAATTTTAAGCATTTAAATGAAATTGATCTTTTTCACTGTATTGAT
CCAAATGATTCCAAGCATAAAAGAACGGACAGATCAATTTTATGTTGTTTACGAAAAGGA
GAATCTGGCCAGTCATGGCCAAGGTTAACAAAAGAAAGGGCAAAGCTTAATTGGCTTAGT
GTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTT
GATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAA
GTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAG
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 160 |
| Molecular Weight
| 18697.195 |
| Theoretical pI
| 4.531 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin E synthase 3
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID
PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF
DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
|
| External Links |
|---|
| GenBank ID Protein
| 158257322 |
| UniProtKB/Swiss-Prot ID
| Q15185 |
| UniProtKB/Swiss-Prot Entry Name
| TEBP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK291945 |
| GeneCard ID
| PTGES3 |
| GenAtlas ID
| PTGES3 |
| HGNC ID
| HGNC:16049 |
| References |
|---|
| General References
| Not Available |