Identification |
HMDB Protein ID
| CDBP04655 |
Secondary Accession Numbers
| Not Available |
Name
| Poly(ADP-ribose) glycohydrolase |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| PARG |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in poly(ADP-ribose) glycohydrolase activity |
Specific Function
| Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells |
GO Classification
|
Function |
hydrolase activity |
hydrolase activity, acting on glycosyl bonds |
hydrolase activity, hydrolyzing o-glycosyl compounds |
poly(adp-ribose) glycohydrolase activity |
catalytic activity |
Process |
metabolic process |
primary metabolic process |
carbohydrate metabolic process |
|
Cellular Location
|
- Isoform 3:Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 10q11.23 |
SNPs
| PARG |
Gene Sequence
|
>2931 bp
ATGAATGCGGGCCCCGGCTGTGAACCCTGCACCAAAGCGACCCGCTGGGGCGCCGCTACA
ACTTCGCCGGCTGCTTCGGACGCCCGGAGCTTTCCGAGCAGGCAGAGGCGCGTCCTCGAC
CCCAAGGACGCTCACGTGCAGTTCAGGGTCCCACCGTCCTCGCCAGCCTGCGTCCCAGGG
CAGGCGGGACAGCACAGAGGCAGCGCCACCTCGCTTGTTTTCAAACAAAAGACTATTACC
AGTTGGATGGACACTAAAGGAATCAAGACAGCGGAATCAGAAAGTTTGGATAGTAAAGAA
AACAACAATACAAGAATAGAATCCATGATGAGTTCTGTACAAAAAGATAACTTTTACCAA
CATAATGTAGAAAAATTAGTAAATGTTTCTCAGCTAAGTCTTGATAAGTCACTCACTGAA
AAAAGTACACAGTATTTGAACCAGCATCAGACTGCAGCAATGTGTAAGTGGCAAAATGAA
GGGAAACACACGGAGCAGCTTTTGGAAAGTGAACCTCAAACAGTAACCCTGGTACCAGAG
CAGTTTAGTAATGCTAACATTGATCGGTCACCTCAAAATGATGATCACAGTGACACAGAT
AGTGAAGAGAATAGAGACAATCAACAGTTTCTCACAACTGTAAAGCTTGCAAATGCAAAG
CAGACTACGGAAGATGAACACGCCAGAGAAGCCAAAAGCCACCAGAAGTGCAGCAAGTCT
TGCCATCCTGGGGAAGACTGTGCAAGTTGTCAGCAAGATGAGATAGACGTGGTGCCAAAG
AGTCCATTGTCAGATGTTGGCTCTGAGGATGTTGGTACTGGGTCAAAAAATGACAACAAA
TTGATTAGACAAGAAAGTTGCCTAGGAAATTCTCCTCCATTTGAGAAGGAAAGTGAACCC
GAATCACCGATGGATGTGGATAATTCTAAAAATAGTTGTCAAGACTCAGAAGCAGATGAG
GAGACAAGTCCAGGTTTTGATGAACAAGAAGATGGTAGTTCCTCCCAAACAGCAAATAAA
CCTTCAAGGTTCCAAGCAAGAGACGCTGACATTGAATTTAGGAAACGGTACTCTACTAAG
GGCGGTGAAGTTAGATTACATTTCCAATTTGAAGGAGGAGAGAGTCGCACTGGAATGAAT
GATTTAAATGCTAAACTACCTGGAAATATTTCTAGCCTGAATGTAGAATGCAGAAATTCT
AAGCAACATGGAAAAAAGGATTCTAAAATCACAGATCATTTGATGAGACTGCCCAAAGCA
GAGGACAGAAGAAAAGAACAGTGGGAAACCAAACATCAAAGAACAGAAAGGAAGATCCCT
AAATACGTTCCACCTCACCTTTCTCCAGATAAGAAGTGGCTTGGAACTCCCATTGAGGAG
ATGAGAAGAATGCCTCGGTGTGGGATCCGGCTGCCTCTCTTGAGACCATCTGCCAATCAC
ACAGTAACTATTCGGGTAGATCTTTTGCGAGCAGGAGAAGTTCCTAAACCTTTTCCAACA
CATTATAAAGATTTGTGGGATAACAAGCATGTTAAAATGCCTTGTTCAGAACAAAATTTG
TACCCAGTGGAAGATGAGAATGGTGAGCGAACTGCGGGGAGCCGGTGGGAGCTCATTCAG
ACTGCACTTCTCAACAAATTTACACGACCCCAAAACTTGAAGGATGCTATTCTGAAATAC
AATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATCGATTTCTGGGATAAGGTA
CTTGAAGAAGCAGAAGCTCAACATTTATATCAGTCCATCTTGCCTGATATGGTGAAAATT
GCACTCTGTCTGCCAAATATTTGCACCCAGCCAATACCACTCCTGAAACAGAAGATGAAT
CATTCCATCACAATGTCGCAGGAACAGATTGCCAGTCTTTTAGCTAATGCTTTCTTCTGC
ACATTTCCACGACGAAATGCTAAGATGAAATCGGAGTATTCTAGTTACCCAGACATTAAC
TTCAATCGATTGTTTGAGGGACGTTCATCAAGGAAACCGGAGAAACTTAAAACGCTCTTC
TGCTACTTTAGAAGAGTCACAGAGAAAAAACCTACTGGGTTGGTGACATTTACAAGACAG
AGTCTTGAAGATTTTCCAGAATGGGAAAGATGTGAAAAACCCTTGACACGATTGCATGTC
ACTTACGAAGGTACCATAGAAGAAAATGGCCAAGGCATGCTACAGGTGGATTTTGCAAAT
CGTTTTGTTGGAGGTGGTGTAACCAGTGCAGGACTTGTGCAAGAAGAAATCCGCTTTTTA
ATCAATCCTGAGTTGATTATTTCACGGCTCTTCACTGAGGTGCTGGATCACAATGAATGT
CTAATTATCACAGGTACTGAGCAGTACAGTGAATACACAGGCTATGCTGAGACATATCGT
TGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGCGAGCGGCGCTGCACTGAG
ATCGTTGCCATCGATGCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAA
ATGAGACGCGAGCTGAACAAGGCTTACTGTGGATTTCTCCGTCCTGGAGTTTCTTCAGAG
AATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCCAGG
TTAAAAGCCTTAATACAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTC
ACCTTTGGGGACTCAGAATTGATGAGAGACATTTACAGCATGCACATTTTCCTTACTGAA
AGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGATACTACAATGAAGAATGC
AGAAACTGTTCCACCCCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTC
GAGTCCTGTGCAGAGACCGCTGACCATTCAGGGCAAAGGACAGGGACCTGA
|
Protein Properties |
Number of Residues
| 976 |
Molecular Weight
| 111109.5 |
Theoretical pI
| 6.39 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Poly(ADP-ribose) glycohydrolase
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
|
External Links |
GenBank ID Protein
| 2213922 |
UniProtKB/Swiss-Prot ID
| Q86W56 |
UniProtKB/Swiss-Prot Entry Name
| PARG_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF005043 |
GeneCard ID
| PARG |
GenAtlas ID
| PARG |
HGNC ID
| HGNC:8605 |
References |
General References
| Not Available |