| Identification |
|---|
| HMDB Protein ID
| CDBP04640 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pterin-4-alpha-carbinolamine dehydratase 2 |
| Description
| Not Available |
| Synonyms
|
- 4-alpha-hydroxy-tetrahydropterin dehydratase 2
- DcoH-like protein DCoHm
- Dimerization cofactor of hepatocyte nuclear factor 1 from muscle
- HNF-1-alpha dimerization cofactor
- PHS 2
|
| Gene Name
| PCBD2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| Specific Function
| Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).
Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
|
| GO Classification
|
| Biological Process |
| positive regulation of transcription, DNA-dependent |
| protein heterooligomerization |
| protein homotetramerization |
| tetrahydrobiopterin biosynthetic process |
| Cellular Component |
| mitochondrion |
| nucleus |
| Function |
| catalytic activity |
| lyase activity |
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| Molecular Function |
| phenylalanine 4-monooxygenase activity |
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| Process |
| cellular biosynthetic process |
| heterocycle biosynthetic process |
| pteridine and derivative biosynthetic process |
| tetrahydrobiopterin biosynthetic process |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q31.1 |
| SNPs
| PCBD2 |
| Gene Sequence
|
>393 bp
ATGGCGGCGGTGCTCGGGGCGCTCGGGGCGACGCGGCGCTTGTTGGCGGCGCTGCGAGGC
CAGAGCCTAGGGCTAGCGGCCATGTCATCAGGTACTCACAGGTTGACTGCAGAGGAGAGG
AACCAAGCTATACTTGACCTTAAAGCAGCAGGATGGTCGGAATTAAGTGAGAGAGATGCC
ATCTACAAAGAATTCTCCTTCCACAATTTTAATCAGGCATTTGGCTTTATGTCCCGAGTT
GCCCTACAAGCAGAGAAGATGAATCATCACCCAGAATGGTTCAATGTATACAACAAGGTC
CAGATAACTCTCACCTCACATGACTGTGGTGAACTGACCAAAAAAGATGTGAAGCTGGCC
AAGTTTATTGAAAAAGCAGCTGCTTCTGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 130 |
| Molecular Weight
| 14365.325 |
| Theoretical pI
| 9.115 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pterin-4-alpha-carbinolamine dehydratase 2
MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDA
IYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLA
KFIEKAAASV
|
| External Links |
|---|
| GenBank ID Protein
| 134133240 |
| UniProtKB/Swiss-Prot ID
| Q9H0N5 |
| UniProtKB/Swiss-Prot Entry Name
| PHS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_032151.4 |
| GeneCard ID
| PCBD2 |
| GenAtlas ID
| PCBD2 |
| HGNC ID
| HGNC:24474 |
| References |
|---|
| General References
| Not Available |