Identification
HMDB Protein ID CDBP04638
Secondary Accession Numbers Not Available
Name Ubiquitin carboxyl-terminal hydrolase 3
Description Not Available
Synonyms
  1. Deubiquitinating enzyme 3
  2. Ubiquitin thiolesterase 3
  3. Ubiquitin-specific-processing protease 3
Gene Name USP3
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin
GO Classification
Function
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 15q22.3
SNPs USP3
Gene Sequence
>1563 bp
ATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCCAAGTTCCCC
AACGGCTCCCCGTCGTCCTGGTGCTGCAGCGTGTGCCGGTCCAACAAAAGCCCTTGGGTC
TGTTTGACTTGTTCAAGTGTCCACTGTGGAAGGTATGTGAATGGCCATGCAAAAAAACAT
TATGAAGATGCACAAGTACCTTTAACCAACCATAAGAAATCAGAAAAGCAAGATAAAGTT
CAGCACACAGTATGTATGGATTGCAGTAGCTACAGTACATACTGTTATCGCTGTGATGAT
TTTGTGGTTAATGACACCAAGCTGGGACTGGTACAGAAAGTCAGAGAACACTTACAGAAC
TTGGAAAACTCAGCTTTCACAGCTGACAGGCATAAGAAAAGAAAACTTTTGGAAAACTCA
ACACTAAACAGCAAGTTATTAAAAGTAAATGGAAGCACCACTGCCATTTGTGCCACAGGC
CTTCGGAATTTGGGGAACACATGTTTCATGAATGCCATCCTTCAGTCACTCAGTAACATT
GAGCAGTTTTGCTGTTATTTCAAAGAACTGCCCGCCGTGGAGTTAAGGAATGGGAAAACA
GCAGGAAGGCGGACATACCACACCAGGAGCCAAGGGGATAACAATGTGTCTTTGGTAGAA
GAGTTTAGAAAGACACTCTGTGCTTTATGGCAAGGCAGCCAGACTGCATTTAGCCCAGAG
TCCTTATTTTATGTTGTTTGGAAGATTATGCCAAACTTTAGGGGCTATCAACAGCAGGAC
GCCCATGAATTCATGCGCTACCTTTTGGACCACCTACACTTGGAACTTCAGGGCGGTTTC
AACGGTGTTTCCCGCTCAGCAATTCTGCAGGAGAATTCTACTCTGTCTGCAAGTAACAAG
TGTTGCATAAATGGAGCATCTACTGTTGTCACGGCTATATTCGGAGGCATTCTCCAAAAT
GAGGTTAACTGCCTCATATGTGGGACAGAATCTAGAAAGTTTGATCCATTCCTAGACCTT
TCATTAGATATTCCAAGTCAGTTCAGAAGTAAGCGCTCTAAGAATCAAGAAAATGGACCA
GTTTGTTCGTTACGAGATTGTCTTCGCAGTTTTACCGACTTAGAAGAACTTGATGAGACA
GAGTTATATATGTGCCATAAATGCAAAAAGAAACAAAAGTCCACAAAAAAGTTTTGGATT
CAAAAACTACCCAAGGTGCTATGCTTACATTTGAAAAGATTTCATTGGACAGCATATTTA
AGAAATAAAGTTGATACATACGTAGAATTTCCACTGAGAGGCCTAGACATGAAATGCTAC
TTACTAGAGCCTGAGAACAGTGGCCCGGAGAGCTGCCTGTATGACCTCGCCGCTGTGGTG
GTGCACCATGGTTCCGGGGTTGGTTCTGGACATTACACAGCATACGCAACTCACGAAGGC
CGCTGGTTCCACTTCAATGACAGTACTGTAACACTGACTGACGAGGAGACTGTGGTGAAG
GCGAAGGCCTACATCCTTTTCTACGTGGAACACCAGGCCAAAGCTGGATCGGATAAACTT
TAA
Protein Properties
Number of Residues 520
Molecular Weight 58896.6
Theoretical pI 8.23
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Ubiquitin carboxyl-terminal hydrolase 3
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKH
YEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQN
LENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNI
EQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPE
SLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNK
CCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGP
VCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYL
RNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEG
RWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL
GenBank ID Protein 55770886
UniProtKB/Swiss-Prot ID Q9Y6I4
UniProtKB/Swiss-Prot Entry Name UBP3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_006537.2
GeneCard ID USP3
GenAtlas ID USP3
HGNC ID HGNC:12626
References
General References Not Available