Cannabis Compound Database: Showing Protein Ubiquitin carboxyl-terminal hydrolase 3 (CDBP04638)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04638

Secondary Accession Numbers

Not Available

Name

Ubiquitin carboxyl-terminal hydrolase 3

Description

Not Available

Synonyms

Deubiquitinating enzyme 3
Ubiquitin thiolesterase 3
Ubiquitin-specific-processing protease 3

Gene Name

USP3

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin thiolesterase activity

Specific Function

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin

GO Classification

Function
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

15q22.3

SNPs

USP3

Gene Sequence

>1563 bp
ATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCCAAGTTCCCC
AACGGCTCCCCGTCGTCCTGGTGCTGCAGCGTGTGCCGGTCCAACAAAAGCCCTTGGGTC
TGTTTGACTTGTTCAAGTGTCCACTGTGGAAGGTATGTGAATGGCCATGCAAAAAAACAT
TATGAAGATGCACAAGTACCTTTAACCAACCATAAGAAATCAGAAAAGCAAGATAAAGTT
CAGCACACAGTATGTATGGATTGCAGTAGCTACAGTACATACTGTTATCGCTGTGATGAT
TTTGTGGTTAATGACACCAAGCTGGGACTGGTACAGAAAGTCAGAGAACACTTACAGAAC
TTGGAAAACTCAGCTTTCACAGCTGACAGGCATAAGAAAAGAAAACTTTTGGAAAACTCA
ACACTAAACAGCAAGTTATTAAAAGTAAATGGAAGCACCACTGCCATTTGTGCCACAGGC
CTTCGGAATTTGGGGAACACATGTTTCATGAATGCCATCCTTCAGTCACTCAGTAACATT
GAGCAGTTTTGCTGTTATTTCAAAGAACTGCCCGCCGTGGAGTTAAGGAATGGGAAAACA
GCAGGAAGGCGGACATACCACACCAGGAGCCAAGGGGATAACAATGTGTCTTTGGTAGAA
GAGTTTAGAAAGACACTCTGTGCTTTATGGCAAGGCAGCCAGACTGCATTTAGCCCAGAG
TCCTTATTTTATGTTGTTTGGAAGATTATGCCAAACTTTAGGGGCTATCAACAGCAGGAC
GCCCATGAATTCATGCGCTACCTTTTGGACCACCTACACTTGGAACTTCAGGGCGGTTTC
AACGGTGTTTCCCGCTCAGCAATTCTGCAGGAGAATTCTACTCTGTCTGCAAGTAACAAG
TGTTGCATAAATGGAGCATCTACTGTTGTCACGGCTATATTCGGAGGCATTCTCCAAAAT
GAGGTTAACTGCCTCATATGTGGGACAGAATCTAGAAAGTTTGATCCATTCCTAGACCTT
TCATTAGATATTCCAAGTCAGTTCAGAAGTAAGCGCTCTAAGAATCAAGAAAATGGACCA
GTTTGTTCGTTACGAGATTGTCTTCGCAGTTTTACCGACTTAGAAGAACTTGATGAGACA
GAGTTATATATGTGCCATAAATGCAAAAAGAAACAAAAGTCCACAAAAAAGTTTTGGATT
CAAAAACTACCCAAGGTGCTATGCTTACATTTGAAAAGATTTCATTGGACAGCATATTTA
AGAAATAAAGTTGATACATACGTAGAATTTCCACTGAGAGGCCTAGACATGAAATGCTAC
TTACTAGAGCCTGAGAACAGTGGCCCGGAGAGCTGCCTGTATGACCTCGCCGCTGTGGTG
GTGCACCATGGTTCCGGGGTTGGTTCTGGACATTACACAGCATACGCAACTCACGAAGGC
CGCTGGTTCCACTTCAATGACAGTACTGTAACACTGACTGACGAGGAGACTGTGGTGAAG
GCGAAGGCCTACATCCTTTTCTACGTGGAACACCAGGCCAAAGCTGGATCGGATAAACTT
TAA

Protein Properties

Number of Residues

520

Molecular Weight

58896.6

Theoretical pI

8.23

Pfam Domain Function

UCH (PF00443 )
zf-UBP (PF02148 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin carboxyl-terminal hydrolase 3
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKH
YEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQN
LENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNI
EQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPE
SLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNK
CCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGP
VCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYL
RNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEG
RWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL

External Links

GenBank ID Protein

55770886

UniProtKB/Swiss-Prot ID

Q9Y6I4

UniProtKB/Swiss-Prot Entry Name

UBP3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_006537.2

GeneCard ID