Cannabis Compound Database: Showing Protein Ubiquitin carboxyl-terminal hydrolase 6 (CDBP04634)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04634

Secondary Accession Numbers

Not Available

Name

Ubiquitin carboxyl-terminal hydrolase 6

Description

Not Available

Synonyms

Deubiquitinating enzyme 6
Proto-oncogene TRE-2
Ubiquitin thiolesterase 6
Ubiquitin-specific-processing protease 6

Gene Name

USP6

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin thiolesterase activity

Specific Function

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation

GO Classification

Component
cell part
intracellular
Function
small gtpase regulator activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ras gtpase activator activity
rab gtpase activator activity
enzyme regulator activity
ubiquitin thiolesterase activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
thiolester hydrolase activity
Process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
metabolic process
regulation of gtpase activity
regulation of rab gtpase activity
regulation of ras gtpase activity
biological regulation
regulation of biological process
regulation of metabolic process

Cellular Location

Cell membrane
Cytoplasm
Endosome

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17p13

SNPs

USP6

Gene Sequence

>4221 bp
ATGGACATGGTAGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATG
AAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAAGGGGCCTGAGCCCGTTGGA
ATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACT
GCACGGGAGGCGAAGAAAATTCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATG
CTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCATAGATCGAGTGTACAAGGGA
ATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAG
TTGAAAAACCCCGGAAGATACCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACAC
ATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAACCATGTCTTCTTTAGGGAT
CGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAAC
CCGGAGGTGGGCTACTGCAGGGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTG
CCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGCCAGTGAGAGGCACTCCCTG
CCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCAT
GTGGTACCCAAGTCACAACCCAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGG
CAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGACGGGATCTCTCTCGGGCTC
ACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACC
AGCATTGCTCTTAAGGTTCAGCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGG
GCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAACGATGACACCGTGCTCAAG
CATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGCC
AAACGCGAGCAAGGGTCCTTGGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACC
CTCTGCAAGGGGTATAGGCAGGCCCCTCCAGGCCCACCAGCCCAGTTCCAGCGGCCCATT
TGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGCCCTGTCCTGGTGGGGCTGTC
CGGGAAGACACGTACCCTGTGGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGA
GGACCTCAGGGTTCCTGGAGATTCCTGGAGTGGAAGTCAATGCCCCGGCTCCCAACGGAC
CTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTGAATGGAGCTGCTGGGTCCGT
GCCATATCCCAGGAGGACCAGCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTT
CACAACAAAGATATGAGTTGGCCTGAGGAGATGTCTTTTACAGCAAATAGTAGTAAAATA
GATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTCTAAGCAACCTGGGAAACACA
TGCTTCATGAACTCAAGCATCCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTT
ATCTCAGGGAGACATCTTTATGAACTCAACAGGACAAATCCCATTGGTATGAAGGGGCAT
ATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGAGTGGAACTCAGAAGAGTGTT
GCCCCATTAAAGCTTCGGCGGACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAG
CAACAAGACTCCCAAGAACTTCTGGCTTTTCTCTTGGATGGTCTTCATGAAGATCTCAAC
CGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTGATGGCCGACCAGACTGGGAA
GTAGCTGCAGAGGCCTGGGACAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTG
TTCCATGGGCAGCTAAGATCTCAAGTCAAATGCAAGACATGTGGGCATATAAGTGTCCGA
TTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGGACAGTTACATGGACTTAGAA
ATAACAGTGATTAAGTTAGATGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATG
GATGAAAAGTACACAGGTTTAAAAAAACAGCTGAGGGATCTCTGTGGACTTAATTCAGAA
CAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGAACTTTCCTCAGGATAACCAA
AAAGTACAACTCTCAGTGAGCGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCT
CCAATTTCAGCTTCTAGTCCAACACAAATAGATTTCTCCTCTTCACCATCTACAAATGGA
ATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAATATTCATCCCCAATGGAATG
CCAAACACTGTTGTGCCATGTGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGT
CACATGCCATCTCTTCCTGACAGCCCCTTTACAGGTTACATCATTGCAGTCCACCGAAAA
ATGATGAGGACAGAACTGTATTTCCTGTCACCTCAGGAGAATCGCCCCAGCCTCTTTGGA
ATGCCATTGATTGTTCCATGCACTGTGCATACCCGGAAGAAAGACCTATATGATGCGGTT
TGGATTCAAGTATCCTGGTTAGCAAGACCACTCCCACCTCAGGAAGCTAGTATTCATGCC
CAGGATCGTGATAACTGTATGGGCTATCAATATCCATTCACTCTACGAGTTGTGCAGAAA
GATGGGAACTCCTGTGCTTGGTGCCCACAGTATAGATTTTGCAGAGGCTGTAAAATTGAT
TGTGGGGAAGACAGAGCTTTCATTGGAAATGCCTATATTGCTGTGGATTGGCACCCCACA
GCCCTTCACCTTCGCTATCAAACATCCCAGGAAAGGGTTGTAGATAAGCATGAGAGTGTG
GAGCAGAGTCGGCGAGCGCAAGCCGAGCCCATCAACCTGGACAGCTGTCTCCGTGCTTTC
ACCAGTGAGGAAGAGCTAGGGGAAAGTGAGATGTACTACTGTTCCAAGTGTAAGACCCAC
TGCTTAGCAACAAAGAAGCTGGATCTCTGGAGGCTTCCACCCTTCCTGATTATTCACCTT
AAGCGATTTCAATTTGTAAATGATCAGTGGATAAAATCACAGAAAATTGTCAGATTTCTT
CGGGAAAGTTTTGATCCGAGTGCTTTTTTGGTACCACGAGACCCGGCCCTCTGCCAGCAT
AAACCACTCACACCCCAGGGGGATGAGCTCTCCAAGCCCAGGATTCTGGCAAGAGAGGTG
AAGAAAGTGGATGCGCAGAGTTCGGCTGGAAAAGAGGACATGCTCCTAAGCAAAAGCCCA
TCCTCACTCAGCGCTAACATCAGCAGCAGCCCAAAAGGTTCTCCTTCTTCATCAAGAAAA
AGTGGAACCAGCTGTCCCTCCAGCAAAAACAGCAGCCCTAATAGCAGCCCACGGACTTTG
GGGAGGAGCAAAGGGAGGCTCCGGCTGCCCCAGATTGGCAGCAAAAATAAGCCGTCAAGT
AGTAAGAAGAACTTGGATGCCAGCAAAGAGAATGGGGCTGGGCAGATCTGTGAGCTGGCT
GACGCCTTGAGCCGAGGGCATATGCGGGGGGGCAGCCAACCAGAGCTGGTCACTCCTCAG
GACCATGAGGTAGCTTTGGCCAATGGATTCCTTTATGAGCATGAAGCATGTGGCAATGGC
TGTGGCGATGGCTACAGCAATGGTCAGCTTGGAAACCACAGTGAAGAAGACAGCACTGAT
GACCAAAGAGAAGACACTCATATTAAGCCTATTTATAATCTATATGCAATTTCATGCCAT
TCAGGAATTCTGAGTGGGGGCCATTACATCACTTATGCCAAAAACCCAAACTGCAAGTGG
TACTGTTATAATGACAGCAGCTGTGAGGAACTTCACCCTGATGAAATTGACACCGACTCT
GCCTACATTCTTTTCTATGAGCAGCAGGGGATAGACTACGCACAATTTCTGCCAAAGATT
GATGGCAAAAAGATGGCAGACACAAGCAGTACGGATGAAGACTCTGAGTCTGATTACGAA
AAGTACTCTATGTTACAGTAA

Protein Properties

Number of Residues

1406

Molecular Weight

158656.8

Theoretical pI

7.75

Pfam Domain Function

TBC (PF00566 )
UCH (PF00443 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin carboxyl-terminal hydrolase 6
MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVT
AREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIK
LKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYN
PEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEH
VVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPIT
SIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKKLTRKQGDLPPPA
KREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAV
REDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVR
AISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNT
CFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSV
APLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWE
VAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLE
ITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQ
KVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGM
PNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFG
MPLIVPCTVHTRKKDLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQK
DGNSCAWCPQYRFCRGCKIDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESV
EQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHL
KRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREV
KKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTL
GRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQ
DHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCH
SGILSGGHYITYAKNPNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLPKI
DGKKMADTSSTDEDSESDYEKYSMLQ

External Links

GenBank ID Protein

24474450

UniProtKB/Swiss-Prot ID

P35125

UniProtKB/Swiss-Prot Entry Name

UBP6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AY143550

GeneCard ID