Identification
HMDB Protein ID CDBP04629
Secondary Accession Numbers Not Available
Name Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
Description Not Available
Synonyms
  1. Deubiquitinating enzyme FAF-Y
  2. Fat facets protein-related, Y-linked
  3. Ubiquitin thiolesterase FAF-Y
  4. Ubiquitin-specific protease 9, Y chromosome
  5. Ubiquitin-specific-processing protease FAF-Y
Gene Name USP9Y
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re- empowers its competence to mediate TGF-beta signaling
GO Classification
Function
thiolester hydrolase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs USP9Y
Gene Sequence
>7668 bp
ATGACAGCCATCACTCATGGCTCTCCAGTAGGAGGGAACGACAGCCAGGGCCAGGTTCTT
GATGGCCAGTCTCAGCATCTCTTCCAACAGAACCAGACTTCATCACCTGATTCTTCCAAT
GAGAATTCCGTAGCAACTCCTCCTCCAGAGGAACAAGGGCAAGGTGATGCCCCACCACAG
CATGAAGATGAAGAGCCTGCATTTCCACATACTGAGCTGGCAAACCTGGATGACATGATC
AACAGGCCTCGATGGGTGGTTCCTGTTTTGCCAAAAGGGGAATTAGAAGTGCTTTTAGAA
GCTGCTATTGATCTTAGTGTAAAAGGCCTTGATGTTAAAAGTGAAGCATGCCAACGTTTT
TTTCGAGATGGACTAACAATATCTTTCACTAAAATTCTTATGGATGAGGCTGTGAGTGGC
TGGAAGTTTGAAATTCATAGATGTATTATTAACAATACTCATCGCCTAGTGGAGCTTTGT
GTGGCCAAGTTGTCCCAAGATTGGTTTCCACTTCTAGAACTTCTCGCCATGGCCTTAAAT
CCTCACTGCAAGTTTCATATCTACAATGGTACACGTCCGTGTGAATTAATTTCCTCAAAT
GCTCAGTTGCCTGAAGATGAATTATTTGCTCGTTCTTCAGATCCTCGATCACCAAAAGGT
TGGCTAGTGGATCTCATCAATAAATTTGGCACATTAAATGGGTTCCAGATTTTGCATGAT
CGTTTTTTTAATGGATCAGCATTAAATATTCAAATAATTGCAGCTCTTATTAAACCATTT
GGACAATGCTATGAGTTTCTCAGTCAACATACACTGAAAAAGTACTTCATTCCAGTTATA
GAAATAGTTCCACATTTATTGGAAAACTTAACTGATGAAGAACTGAAAAAGGAGGCAAAG
AATGAAGCCAAAAATGATGCCCTTTCAATGATTATTAAATCTTTGAAGAACTTAGCTTCA
AGAATTTCAGGACAAGATGAGACTATAAAAAATTTGGAAATTTTTAGGTTAAAGATGATA
CTCAGATTGTTGCAAATTTCCTCTTTTAATGGAAAGATGAATGCACTGAATGAAATAAAT
AAGGTTATATCTAGTGTATCATATTATACTCATCGGCATAGTAATCCTGAGGAGGAAGAA
TGGCTGACAGCTGAGCGAATGGCAGAATGGATACAGCAAAATAATATCTTATCCATAGTC
TTGCAAGACAGTCTTCATCAACCACAATATGTAGAAAAGCTAGAGAAAATTCTTCGTTTT
GTGATTAAAGAAAAGGCTCTTACATTACAGGACCTTGATAATATCTGGGCAGCACAGGCA
GGAAAACATGAAGCCATTGTGAAGAATGTACATGATCTGCTAGCAAAGTTGGCTTGGGAT
TTTTCTCCTGGACAACTTGATCATCTTTTTGATTGCTTTAAGGCAAGTTGGACAAATGCA
AGTAAAAAGCAACGTGAAAAGCTCCTTGAGTTGATACGCCGTCTTGCAGAAGATGATAAA
GATGGTGTGATGGCACACAAAGTGTTGAACCTTCTTTGGAACCTGGCTCAGAGTGATGAT
GTGCCTGTAGACATCATGGACCTTGCTCTTAGTGCCCACATAAAAATACTAGATTATAGT
TGTTCCCAGGATCGAGATGCACAGAAGATCCAGTGGATAGATCACTTTATAGAAGAACTT
CGCACAAATGACAAGTGGGTAATTCCTGCTCTGAAACAAATAAGAGAAATTTGTAGTTTG
TTTGGTGAAGCATCTCAAAATTTGAGTCAAACTCAGCGAAGTCCCCACATATTTTATCGC
CATGATTTAATCAACCAGCTTCAACAAAATCATGCTTTAGTTACTTTGGTAGCAGAAAAC
CTTGCAACCTACATGAATAGCATCAGATTGTATGCTGGAGATCATGAAGACTATGATCCA
CAAACAGTGAGGCTTGGAAGTCGATACAGTCATGTTCAAGAAGTTCAAGAACGACTAAAC
TTCCTTAGATTTTTACTGAAGGATGGCCAACTGTGGCTCTGTGCTCCTCAGGCAAAACAA
ATATGGAAGTGCTTAGCAGAAAATGCAGTTTATCTTTGTGATCGTGAAGCCTGTTTTAAG
TGGTATTCCAAGTTAATGGGGGATGAACCAGACTTGGATCCTGATATTAATAAGGACTTC
TTTGAAAGTAATGTACTTCAGCTTGATCCTTCCCTTTTAACTGAAAATGGAATGAAATGC
TTTGAAAGATTTTTCAAAGCTGTCAATTGTCGAGAAAGGAAACTAATAGCAAAAAGAAGA
TCCTATATGATGGATGATTTGGAATTAATTGGACTAGACTACCTTTGGAGGGTTGTGATT
CAGAGTAGTGACGAGATTGCTAACAGAGCTATAGATCTTCTTAAAGAGATATACACAAAC
CTTGGCCCAAGATTAAAAGCCAATCAGGTGGTTATCCATGAAGACTTCATTCAGTCTTGC
TTTGATCGTTTAAAAGCATCATATGATACACTGTGTGTTTTTGATGGTGACAAAAACAGC
ATTAATTGTGCAAGACAAGAAGCCATTCGAATGGTTAGAGTATTAACTGTTATAAAAGAG
TACATTAATGAATGTGACAGTGATTATCACAAGGAAAGAATGATTCTACCTATGTCGAGA
GCATTTCGTGGCAAACACCTCTCTCTTATAGTTCGGTTTCCAAACCAGGGCAGACAGGTT
GATGAGTTGGATATATGGTCTCATACGAATGACACAATTGGTTCAGTACGGCGATGTATT
GTTAATCGTATTAAAGCCAATGTAGCCCACAAAAAAATTGAACTTTTTGTGGGTGGTGAG
CTGATAGATTCTGAAGATGACAGAAAGCTAATTGGACAATTAAACTTAAAAGATAAATCT
CTAATTACAGCCAAACTTACACAAATAAATTTCAATATGCCATCAAGTCCTGATAGCTCT
TCCGATTCCTCAACTGCATCTCCTGGAAACCACCGTAATCATTACAATGATGGTCCCAAT
CTAGAGGTGGAAAGTTGTTTGCCTGGGGTGATAATGTCAGTGCATCCCAGATACATCTCT
TTCCTTTGGCAAGTTGCAGACTTAGGTAGCAACCTGAATATGCCACCTCTTAGAGATGGA
GCAAGAGTACTTATGAAACTTATGCCACCAGATAGAACAGCTGTAGAAAAATTACGAGCT
GTTTGTTTGGACCATGCAAAACTTGGAGAAGGCAAACTTAGTCCACCCCTTGACTCTCTT
TTCTTTGGTCCTTCTGCCTCCCAAGTTCTATACCTAACAGAGGTAGTTTATGCCTTGTTA
ATGCCTGCTGGTGTGCCTCTAACTGATGGGTCCTCTGACTTTCAAGTTCACTTCTTGAAA
AGTGGTGGCTTACCTCTTGTACTGAGTATGCTAATAAGAAATAACTTCTTGCCAAATACA
GATATGGAAACTCGAAGGGGTGCTTATTTAAATGCTCTTAAAATAGCCAAACTGTTGTTA
ACTGCGATTGGCTATGGCCATGTTCGAGCTGTAGCAGAAGCTTGTCAGCCAGTTGTAGAT
GGTACAGACCCCATAACACAGATTAACCAAGTTACTCATGATCAAGCAGTGGTGCTACAA
AGTGCCCTTCAGAGCATTCCTAATCCCTCATCCGAGTGCGTACTTAGAAATGAGTCCATA
CTTCTTGCTCAGGAAATATCTAATGAGGCTTCAAGATATATGCCTGATATTTGTGTAATT
AGGGCTATACAGAAAATTATCTGGGCATCAGCATGTGGGGCATTAGGACTAGTTTTTAGC
CCAAATGAAGAAATAACTAAAATTTATCAGATGACCACCAATGGAAGCAATAAGCTGGAG
GTGGAAGATGAACAAGTTTGCTGTGAAGCACTGGAAGTGATGACCTTATGTTTTGCTTTA
CTTCCAACAGCGTTGGATGCACTTAGTAAAGAAAAAGCCTGGCAGACCTTCATCATTGAC
TTATTATTGCACTGTCCAAGCAAAACTGTTCGTCAGTTGGCACAGGAGCAGTTCTTTTTA
ATGTGCACCAGATGTTGCATGGGACACAGGCCTCTGCTTTTCTTCATTACTTTACTCTTT
ACCATACTGGGGAGCACAGCAAGAGAGAAGGGTAAATATTCAGGTGATTATTTCACACTT
TTACGGCACCTTCTCAATTATGCTTACAATGGCAATATTAACATACCCAATGCTGAAGTT
CTTCTTGTCAGTGAAATTGATTGGCTCAAAAGGATTAGGGATAATGTTAAAAACACAGGT
GAAACAGGTGTCGAAGAGCCAATACTGGAAGGCCACCTTGGGGTAACAAAAGAGTTATTG
GCCTTTCAAACTTCTGAGAAAAAGTATCACTTTGGTTGTGAAAAAGGAGGTGCTAATCTC
ATTAAAGAATTAATTGATGATTTCATCTTTCCCGCATCCAAAGTTTACCTGCAGTATTTA
AGAAGTGGAGAACTACCAGCTGAGCAGGCTATTCCAGTCTGTAGTTCACCCGTTACCATC
AATGCCGGTTTTGAGCTACTTGTAGCATTAGCTATTGGCTGTGTGAGGAATCTCAAACAG
ATAGTAGACTGTTTGACTGAAATGTATTACATGGGCACAGCAATTACTACTTGTGAAGCA
CTTACTGAGTGGGAATATCTGCCCCCTGTTGGACCCCGCCCACCAAAAGGATTTGTGGGA
CTCAAAAATGCTGGTGCTACGTGTTACATGAACTCTGTGATCCAGCAGCTATACATGATT
CCTTCTATCAGGAACAGTATTCTTGCAATTGAAGGCACAGGTAGTGATTTACACGATGAT
ATGTTCGGGGATGAGAAGCAGGACAGTGAGAGTAATGTTGATCCCCGAGATGATGTATTT
GGATATCCTCATCAATTTGAAGACAAGCCAGCATTAAGTAAGACAGAAGATAGGAAAGAG
TATAATATTGGTGTCCTAAGACACCTTCAGGTCATCTTTGGTCATTTAGCTGCTTCCCAA
CTACAATACTATGTACCCAGAGGATTTTGGAAACAGTTCAGGCTTTGGGGTGAACCTGTT
AATCTCCGTGAACAACATGATGCCTTAGAGTTTTTTAATTCTTTGGTGGATAGTTTAGAT
GAAGCTTTAAAAGCTTTAGGACACCCGGCTATACTAAGTAAAGTCCTAGGAGGCTCCTTT
GCTGATCAGAAGATCTGCCAAGGCTGCCCACATAGGTATGAATGTGAAGAATCTTTTACA
ACTTTGAATGTGGATATTAGAAATCATCAAAATCTTCTTGACTCTTTGGAACAGTATATC
AAAGGAGATTTATTGGAAGGTGCAAATGCATATCATTGTGAAAAATGTGATAAAAAGGTT
GACACAGTAAAGCGCCTGCTAATTAAAAAATTGCCTCGGGTTCTTGCTATCCAACTCAAA
CGATTTGACTATGACTGGGAAAGAGAATGTGCAATTAAATTCAATGATTATTTTGAATTT
CCTCGAGAGCTGGATATGGGACCTTACACAGTAGCAGGTGTTGCAAACCTGGAAAGGGAT
AATGTAAACTCAGAAAATGAGTTGATTGAACAGAAAGAGCAGTCTGACAATGAAACTGCA
GGAGGCACAAAGTACAGACTTGTAGGAGTGCTTGTACACAGTGGTCAAGCAAGCGGTGGG
CATTATTATTCTTACATCATTCAAAGGAATGGTAAAGATGATCAGACAGATCACTGGTAT
AAATTTGATGATGGAGATGTAACAGAATGCAAAATGGATGATGATGAAGAAATGAAAAAT
CAGTGTTTTGGTGGAGAGTACATGGGAGAAGTATTTGATCACATGATGAAGCGCATGTCA
TATAGGCGACAGAAGAGGTGGTGGAATGCTTACATACTTTTTTATGAACAAATGGATATG
ATAGATGAAGATGATGAGATGATAAGATACATATCAGAGCTAACTATTGCAAGACCCCAT
CAGATCATTATGTCACCAGCCATTGAGAGAAGTGTACGGAAACAAAATGTGAAATTTATG
CATAACCGATTGCAATATAGTTTAGAGTATTTTCAGTTTGTGAAAAAACTGCTTACATGT
AATGGTGTTTATTTAAACCCTGCTCCAGGGCAGGATTATTTGTTGCCTGAAGCAGAAGAA
ATTACTATGATTAGTATTCAGCTTGCTGCTAGATTCCTCTTTACCACTGGATTTCACACC
AAGAAAATAGTTCGTGGTCCTGCCAGTGACTGGTATGATGCACTGTGCGTTCTTCTCCGT
CACAGCAAAAATGTACGTTTTTGGTTTACTCATAATGTCCTTTTTAATGTATCAAATCGC
TTCTCTGAATACCTTCTGGAGTGCCCTAGTGCAGAAGTGAGGGGTGCATTTGCAAAACTT
ATAGTGTTTATTGCACACTTTTCCTTGCAAGATGGGTCTTGTCCTTCTCCTTTTGCATCT
CCAGGACCTTCTAGTCAGGCATGTGATAACTTGAGCTTGAGTGACCACTTACTAAGAGCC
ACACTAAATCTCTTGAGAAGGGAAGTTTCAGAGCATGGACATCATTTACAGCAATATTTT
AATTTGTTTGTAATGTATGCCAATTTAGGTGTGGCAGAAAAAACACAGCTTCTGAAATTG
AATGTACCTGCTACCTTTATGCTTGTGTCTTTAGACGAAGGACCAGGTCCTCCAATCAAA
TATCAGTATGCTGAATTAGGCAAGTTATATTCAGTAGTGTCTCAGCTGATTCGTTGTTGC
AATGTGTCATCAACAATGCAGTCTTCAATCAATGGTAATCCCCCTCTCCCCAATCCTTTC
GGTGACCTTAATTTATCACAGCCTATAATGCCAATTCAGCAGAATGTGTTAGACATTTTA
TTTGTGAGAACAAGTTATGTGAAGAAAATTATTGAAGACTGCAGTAACTCAGAGGATACC
ATCAAATTACTTCGCTTTTGCTCTTGGGAGAATCCTCAGTTCTCATCTACTGTCCTCAGC
GAACTTCTCTGGCAGGTTGCATATTCATATACCTATGAACTTCGGCCATATTTAGATCTA
CTTTTCCAAATTTTACTGATTGAGGACTCCTGGCAGACTCACAGAATTCATAATGCACTT
AAAGGAATTCCAGATGACAGAGATGGGCTGTTCGATACAATACAGCGCTCGAAGAATCAC
TATCAAAAACGAGCATATCAGTGCATAAAATGTATGGTAGCTCTATTTAGCAGTTGTCCT
GTTGCTTACCAGATCTTACAGGGTAACGGAGATCTTAAAAGAAAATGGACCTGGGCAGTG
GAATGGCTAGGAGATGAACTTGAAAGAAGACCATATACTGGCAATCCTCAGTATAGTTAC
AACAATTGGTCTCCTCCAGTACAAAGCAATGAAACAGCAAATGGTTATTTCTTAGAAAGA
TCACATAGTGCTAGGATGACACTTGCAAAAGCTTGTGAACTCTGTCCAGAAGAGGAGCCA
GATGACCAGGATGCCCCAGATGAGCATGAGCCCTCTCCATCAGAAGATGCCCCATTATAT
CCTCATTCACCTGCCTCTCAGTATCAACAGAATAATCATGTACATGGACAGCCATATACA
GGACCAGCAGCACATCACTTGAACAACCCTCAGAAAACAGGCCAACGAACACAAGAAAAT
TATGAAGGCAATGAAGAAGTATCCTCACCTCAGATGAAGGATCAGTGA
Protein Properties
Number of Residues 2555
Molecular Weight 291074.2
Theoretical pI 5.68
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
MTAITHGSPVGGNDSQGQVLDGQSQHLFQQNQTSSPDSSNENSVATPPPEEQGQGDAPPQ
HEDEEPAFPHTELANLDDMINRPRWVVPVLPKGELEVLLEAAIDLSVKGLDVKSEACQRF
FRDGLTISFTKILMDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALN
PHCKFHIYNGTRPCELISSNAQLPEDELFARSSDPRSPKGWLVDLINKFGTLNGFQILHD
RFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYFIPVIEIVPHLLENLTDEELKKEAK
NEAKNDALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRLLQISSFNGKMNALNEIN
KVISSVSYYTHRHSNPEEEEWLTAERMAEWIQQNNILSIVLQDSLHQPQYVEKLEKILRF
VIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPGQLDHLFDCFKASWTNA
SKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAQSDDVPVDIMDLALSAHIKILDYS
CSQDRDAQKIQWIDHFIEELRTNDKWVIPALKQIREICSLFGEASQNLSQTQRSPHIFYR
HDLINQLQQNHALVTLVAENLATYMNSIRLYAGDHEDYDPQTVRLGSRYSHVQEVQERLN
FLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDF
FESNVLQLDPSLLTENGMKCFERFFKAVNCRERKLIAKRRSYMMDDLELIGLDYLWRVVI
QSSDEIANRAIDLLKEIYTNLGPRLKANQVVIHEDFIQSCFDRLKASYDTLCVFDGDKNS
INCARQEAIRMVRVLTVIKEYINECDSDYHKERMILPMSRAFRGKHLSLIVRFPNQGRQV
DELDIWSHTNDTIGSVRRCIVNRIKANVAHKKIELFVGGELIDSEDDRKLIGQLNLKDKS
LITAKLTQINFNMPSSPDSSSDSSTASPGNHRNHYNDGPNLEVESCLPGVIMSVHPRYIS
FLWQVADLGSNLNMPPLRDGARVLMKLMPPDRTAVEKLRAVCLDHAKLGEGKLSPPLDSL
FFGPSASQVLYLTEVVYALLMPAGVPLTDGSSDFQVHFLKSGGLPLVLSMLIRNNFLPNT
DMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPVVDGTDPITQINQVTHDQAVVLQ
SALQSIPNPSSECVLRNESILLAQEISNEASRYMPDICVIRAIQKIIWASACGALGLVFS
PNEEITKIYQMTTNGSNKLEVEDEQVCCEALEVMTLCFALLPTALDALSKEKAWQTFIID
LLLHCPSKTVRQLAQEQFFLMCTRCCMGHRPLLFFITLLFTILGSTAREKGKYSGDYFTL
LRHLLNYAYNGNINIPNAEVLLVSEIDWLKRIRDNVKNTGETGVEEPILEGHLGVTKELL
AFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQYLRSGELPAEQAIPVCSSPVTI
NAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWEYLPPVGPRPPKGFVG
LKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSESNVDPRDDVF
GYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFRLWGEPV
NLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGCPHRYECEESFT
TLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLK
RFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELIEQKEQSDNETA
GGTKYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWYKFDDGDVTECKMDDDEEMKN
QCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYEQMDMIDEDDEMIRYISELTIARPH
QIIMSPAIERSVRKQNVKFMHNRLQYSLEYFQFVKKLLTCNGVYLNPAPGQDYLLPEAEE
ITMISIQLAARFLFTTGFHTKKIVRGPASDWYDALCVLLRHSKNVRFWFTHNVLFNVSNR
FSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGSCPSPFASPGPSSQACDNLSLSDHLLRA
TLNLLRREVSEHGHHLQQYFNLFVMYANLGVAEKTQLLKLNVPATFMLVSLDEGPGPPIK
YQYAELGKLYSVVSQLIRCCNVSSTMQSSINGNPPLPNPFGDLNLSQPIMPIQQNVLDIL
FVRTSYVKKIIEDCSNSEDTIKLLRFCSWENPQFSSTVLSELLWQVAYSYTYELRPYLDL
LFQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCP
VAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYSYNNWSPPVQSNETANGYFLER
SHSARMTLAKACELCPEEEPDDQDAPDEHEPSPSEDAPLYPHSPASQYQQNNHVHGQPYT
GPAAHHLNNPQKTGQRTQENYEGNEEVSSPQMKDQ
GenBank ID Protein 74319833
UniProtKB/Swiss-Prot ID O00507
UniProtKB/Swiss-Prot Entry Name USP9Y_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004654.3
GeneCard ID USP9Y
GenAtlas ID USP9Y
HGNC ID HGNC:12633
References
General References Not Available