Identification
HMDB Protein ID CDBP04623
Secondary Accession Numbers Not Available
Name Ubiquitin carboxyl-terminal hydrolase 29
Description Not Available
Synonyms
  1. Deubiquitinating enzyme 29
  2. Ubiquitin thiolesterase 29
  3. Ubiquitin-specific-processing protease 29
Gene Name USP29
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
metabolic process
catabolic process
macromolecule catabolic process
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.43
SNPs USP29
Gene Sequence
>2769 bp
ATGATATCTCTAAAGGTATGTGGATTCATCCAAATTTGGAGCCAGAAGACTGGGATGACT
AAGCTGAAAGAAGCTCTCATTGAAACAGTGCAAAGACAAAAGGAAATTAAACTGGTGGTC
ACTTTCAAATCTGGAAAATTTATAAGAATTTTTCAGCTGAGCAACAACATTAGAAGTGTG
GTCCTTAGACATTGTAAAAAAAGACAAAGTCACCTGCGTTTAACTTTGAAAAACAACGTG
TTCTTGTTTATTGACAAATTATCCTACAGAGATGCTAAACAGTTGAATATGTTCCTGGAC
ATAATCCACCAAAACAAATCTCAGCAACCCATGAAATCTGATGATGATTGGAGTGTGTTT
GAAAGCAGGAATATGCTGAAGGAAATTGACAAAACTTCATTTTACAGCATTTGTAACAAG
CCAAGTTATCAGAAGATGCCTTTGTTTATGTCAAAATCACCAACACATGTGAAAAAGGGG
ATATTAGAAAATCAAGGTGGGAAGGGGCAAAACACACTATCATCTGATGTACAGACAAAT
GAGGACATTCTGAAGGAAGATAACCCTGTACCAAACAAGAAATATAAGACAGATTCCTTG
AAATATATACAAAGCAATAGGAAGAACCCATCAAGTTTAGAGGATTTAGAAAAAGATAGA
GATTTGAAACTCGGGCCTTCATTCAATACCAACTGTAATGGAAATCCTAACCTAGATGAG
ACTGTTCTTGCAACCCAGACTCTCAATGCCAAAAATGGTTTGACATCTCCATTGGAACCA
GAGCACAGCCAGGGTGACCCAAGATGCAACAAAGCCCAGGTGCCTCTTGACTCTCATTCA
CAGCAACTGCAGCAGGGGTTCCCCAATTTGGGAAACACCTGTTACATGAATGCAGTTTTA
CAATCGCTATTTGCAATTCCATCTTTTGCTGATGACTTACTCACTCAAGGTGTCCCATGG
GAATATATTCCCTTTGAGGCTCTTATTATGACCTTGACCCAGCTGCTTGCTTTGAAAGAT
TTCTGTAGTACAAAGATCAAGAGAGAATTACTTGGGAATGTTAAAAAAGTCATTTCAGCA
GTTGCAGAAATATTTTCTGGCAACATGCAGAATGATGCTCATGAGTTTTTAGGTCAGTGT
TTAGACCAGCTGAAAGAAGACATGGAAAAATTAAATGCCACTTTGAATACTGGGAAAGAA
TGTGGGGATGAAAATTCATCTCCACAAATGCATGTTGGTAGTGCTGCCACCAAAGTGTTT
GTTTGCCCTGTTGTTGCTAATTTTGAGTTTGAATTGCAGCTCTCCCTTATTTGTAAAGCT
TGTGGTCATGCTGTTCTCAAGGTAGAACCTAATAATTATCTCTCCATCAACCTGCACCAA
GAAACAAAACCACTTCCTTTGTCCATTCAGAATTCTTTAGATCTTTTCTTTAAAGAAGAA
GAGCTTGAATATAACTGTCAGATGTGTAAGCAGAAGAGTTGTGTTGCAAGGCATACATTT
AGTAGGCTCTCCAGGGTCCTTATCATTCATCTGAAACGCTATAGCTTCAACAATGCTTGG
TTGCTGGTGAAGAATAACGAGCAAGTTTATATTCCCAAATCTTTAAGTTTATCTTCTTAT
TGCAATGAAAGCACCAAACCACCTCTTCCCTTGAGCAGTAGTGCACCTGTTGGGAAATGT
GAAGTCCTGGAAGTCTCTCAGGAGATGATTTCTGAGATCAACAGCCCATTGACACCATCA
ATGAAGCTGACCTCAGAATCCAGTGATTCCCTGGTTCTACCCGTTGAACCAGACAAGAAT
GCCGACCTACAAAGATTCCAGAGAGACTGTGGAGATGCAAGCCAAGAGCAGCATCAGAGA
GACCTGGAAAATGGCTCTGCACTAGAGTCAGAATTGGTCCACTTTAGAGATAGGGCAATC
GGTGAAAAGGAGCTTCCAGTGGCTGACTCACTGATGGACCAGGGAGACATTTCTCTTCCT
GTGATGTATGAAGATGGAGGGAAGCTGATCAGCAGCCCAGACACAAGGCTTGTCGAGGTT
CATCTTCAAGAGGTGCCTCAACATCCAGAACTTCAGAAGTATGAGAAAACCAATACATTC
GTAGAGTTCAATTTTGACAGTGTCACTGAGTCCACCAATGGCTTTTATGACTGTAAAGAA
AACAGGATTCCAGAAGGATCTCAAGGAATGGCTGAACAGCTCCAGCAGTGTATTGAGGAG
AGCATCATAGATGAATTTCTTCAGCAGGCACCACCTCCAGGTGTTAGGAAGCTGGATGCC
CAGGAACATACAGAAGAGACCCTCAATCAGTCTACAGAATTAAGACTTCAAAAGGCTGAC
CTGAATCACCTTGGGGCACTGGGTTCTGACAACCCAGGAAACAAAAACATTTTAGATGCA
GAGAACACAAGAGGTGAAGCCAAGGAACTAACAAGAAACGTGAAGATGGGGGATCCTCTC
CAGGCCTACAGACTCATCAGTGTTGTCAGCCATATCGGGAGCTCCCCAAATTCAGGCCAT
TACATCAGCGATGTGTATGACTTTCAGAAGCAGGCCTGGTTCACATACAACGATCTATGT
GTATCAGAAATCTCAGAGACCAAAATGCAGGAGGCGAGGCTTCACTCTGGGTATATCTTC
TTTTACATGCACAATGGGATTTTTGAGGAGCTGTTAAGAAAAGCAGAGAACTCTCGGCTA
CCTAGCACACAGGCAGGGGTGATCCCTCAGGGGGAATACGAAGGTGACTCTTTGTACAGA
CCTGCTTGA
Protein Properties
Number of Residues 922
Molecular Weight 104155.2
Theoretical pI 5.74
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Ubiquitin carboxyl-terminal hydrolase 29
MISLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSV
VLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFLDIIHQNKSQQPMKSDDDWSVF
ESRNMLKEIDKTSFYSICNKPSYQKMPLFMSKSPTHVKKGILENQGGKGQNTLSSDVQTN
EDILKEDNPVPNKKYKTDSLKYIQSNRKNPSSLEDLEKDRDLKLGPSFNTNCNGNPNLDE
TVLATQTLNAKNGLTSPLEPEHSQGDPRCNKAQVPLDSHSQQLQQGFPNLGNTCYMNAVL
QSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKDFCSTKIKRELLGNVKKVISA
VAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECGDENSSPQMHVGSAATKVF
VCPVVANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPLPLSIQNSLDLFFKEE
ELEYNCQMCKQKSCVARHTFSRLSRVLIIHLKRYSFNNAWLLVKNNEQVYIPKSLSLSSY
CNESTKPPLPLSSSAPVGKCEVLEVSQEMISEINSPLTPSMKLTSESSDSLVLPVEPDKN
ADLQRFQRDCGDASQEQHQRDLENGSALESELVHFRDRAIGEKELPVADSLMDQGDISLP
VMYEDGGKLISSPDTRLVEVHLQEVPQHPELQKYEKTNTFVEFNFDSVTESTNGFYDCKE
NRIPEGSQGMAEQLQQCIEESIIDEFLQQAPPPGVRKLDAQEHTEETLNQSTELRLQKAD
LNHLGALGSDNPGNKNILDAENTRGEAKELTRNVKMGDPLQAYRLISVVSHIGSSPNSGH
YISDVYDFQKQAWFTYNDLCVSEISETKMQEARLHSGYIFFYMHNGIFEELLRKAENSRL
PSTQAGVIPQGEYEGDSLYRPA
GenBank ID Protein 9971757
UniProtKB/Swiss-Prot ID Q9HBJ7
UniProtKB/Swiss-Prot Entry Name UBP29_HUMAN
PDB IDs Not Available
GenBank Gene ID AF229438
GeneCard ID USP29
GenAtlas ID USP29
HGNC ID HGNC:18563
References
General References Not Available