Identification
HMDB Protein ID CDBP04614
Secondary Accession Numbers Not Available
Name STAM-binding protein
Description Not Available
Synonyms
  1. Associated molecule with the SH3 domain of STAM
  2. Endosome-associated ubiquitin isopeptidase
Gene Name STAMBP
Protein Type Enzyme
Biological Properties
General Function Involved in metal ion binding
Specific Function Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Membrane
  5. Early endosome
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2p13.1
SNPs STAMBP
Gene Sequence
>1275 bp
ATGTCTGACCATGGAGATGTGAGCCTCCCGCCCGAAGACCGGGTGAGGGCTCTCTCCCAG
CTGGGTAGTGCGGTAGAGGTGAATGAAGACATTCCACCCCGTCGGTACTTCCGCTCTGGA
GTTGAGATTATCCGAATGGCATCCATTTACTCTGAGGAAGGCAACATTGAACATGCCTTC
ATCCTCTATAACAAGTATATCACGCTCTTTATTGAGAAACTACCAAAACATCGAGATTAC
AAATCTGCTGTCATTCCTGAAAAGAAAGACACAGTAAAGAAATTAAAGGAGATTGCATTT
CCCAAAGCAGAAGAGCTGAAGGCAGAGCTGTTAAAACGATATACCAAAGAATATACAGAA
TATAATGAAGAAAAGAAGAAGGAAGCAGAGGAATTGGCCCGGAACATGGCCATCCAGCAA
GAGCTGGAAAAGGAAAAACAGAGGGTAGCACAACAGAAGCAGCAGCAATTGGAACAGGAA
CAGTTCCATGCCTTCGAGGAGATGATCCGGAACCAGGAGCTAGAAAAAGAGCGACTGAAA
ATTGTACAGGAGTTTGGGAAGGTAGACCCTGGCCTAGGTGGCCCGCTAGTGCCTGACTTG
GAGAAGCCCTCCTTAGATGTGTTCCCCACCTTAACAGTCTCATCCATACAGCCTTCAGAC
TGTCACACAACTGTAAGGCCAGCTAAGCCACCTGTGGTGGACAGGTCCTTGAAACCTGGA
GCACTGAGCAACTCAGAAAGTATTCCCACAATCGATGGATTGCGCCATGTGGTGGTGCCT
GGGCGGCTGTGCCCACAGTTTCTCCAGTTAGCCAGTGCCAACACTGCCCGGGGAGTGGAG
ACATGTGGAATTCTCTGTGGAAAACTGATGAGGAATGAATTTACCATTACCCATGTTCTC
ATCCCCAAGCAAAGTGCTGGGTCTGATTACTGCAACACAGAGAACGAAGAAGAACTTTTC
CTCATACAGGATCAGCAGGGCCTCATCACACTGGGCTGGATTCATACTCACCCCACACAG
ACCGCGTTTCTCTCCAGTGTCGACCTACACACTCACTGCTCTTACCAGATGATGTTGCCA
GAGTCAGTAGCCATTGTTTGCTCCCCCAAGTTCCAGGAAACTGGATTCTTTAAACTAACT
GACCATGGACTAGAGGAGATTTCTTCCTGTCGCCAGAAAGGATTTCATCCACACAGCAAG
GATCCACCTCTGTTCTGTAGCTGCAGCCACGTGACTGTTGTGGACAGAGCAGTGACCATC
ACAGACCTTCGATGA
Protein Properties
Number of Residues 424
Molecular Weight 48076.5
Theoretical pI 6.24
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>STAM-binding protein
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAF
ILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTE
YNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLK
IVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPG
ALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVL
IPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLP
ESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTI
TDLR
GenBank ID Protein 62630163
UniProtKB/Swiss-Prot ID O95630
UniProtKB/Swiss-Prot Entry Name STABP_HUMAN
PDB IDs Not Available
GenBank Gene ID AC073046
GeneCard ID STAMBP
GenAtlas ID STAMBP
HGNC ID HGNC:16950
References
General References Not Available